{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:54:45Z","timestamp":1773518085550,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.ijrobp.2010.11.022","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T07:09:08Z","timestamp":1294988948000},"page":"299-307","source":"Crossref","is-referenced-by-count":78,"title":["Tumor Metabolism and Perfusion in Head and Neck Squamous Cell Carcinoma: Pretreatment Multimodality Imaging With 1H Magnetic Resonance Spectroscopy, Dynamic Contrast-Enhanced MRI, and [18F]FDG-PET"],"prefix":"10.1016","volume":"82","author":[{"given":"Jacobus F.A.","family":"Jansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Sch\u00f6der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilda. E.","family":"Stambuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew G.","family":"Fury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snehal G.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatin P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Koutcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amita","family":"Shukla-Dave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2010.11.022_bib1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2967\/jnumed.107.044792","article-title":"Clinical utility of [18F]FDG PET\/CT in assessing the neck after concurrent chemoradiotherapy for locoregional advanced head and neck cancer","volume":"49","author":"Ong","year":"2008","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/j.semnuclmed.2004.03.004","article-title":"Positron emission imaging of head and neck cancer, including thyroid carcinoma","volume":"34","author":"Schoder","year":"2004","journal-title":"Semin Nucl Med"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib3","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1200\/JCO.2002.02.590","article-title":"Diagnostic and prognostic value of [(18)F]fluorodeoxyglucose positron emission tomography for recurrent head and neck squamous cell carcinoma","volume":"20","author":"Wong","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib4","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.ijrobp.2004.05.058","article-title":"Value of FDG PET in assessment of treatment response and surveillance in head\u2013and-neck cancer patients after intensity modulated radiation treatment: a preliminary report","volume":"60","author":"Yao","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijrobp.2008.07.019","article-title":"Clinical significance of postradiotherapy [18F]-fluorodeoxyglucose positron emission tomography imaging in management of head-and-neck cancer-a long-term outcome report","volume":"74","author":"Yao","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl 2","key":"10.1016\/j.ijrobp.2010.11.022_bib6","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.2967\/jnumed.107.045930","article-title":"Tumor cell metabolism imaging","volume":"49","author":"Plathow","year":"2008","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib7","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1001\/archotol.130.12.1361","article-title":"FDG-PET prediction of head and neck squamous cell cancer outcomes","volume":"130","author":"Schwartz","year":"2004","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.oraloncology.2003.12.002","article-title":"Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck","volume":"40","author":"Asaumi","year":"2004","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib9","first-page":"80","article-title":"Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells","volume":"59","author":"Aboagye","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib10","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1200\/JCO.2006.06.8080","article-title":"Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker","volume":"24","author":"Hylton","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib11","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.ijrobp.2005.03.066","article-title":"The role of FDG PET in management of neck metastasis from head-and-neck cancer after definitive radiation treatment","volume":"63","author":"Yao","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib12","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.2967\/jnumed.109.062638","article-title":"Dose painting in radiotherapy for head and neck squamous cell carcinoma: value of repeated functional imaging with (18)F-FDG PET, (18)F-fluoromisonidazole PET, diffusion-weighted MRI, and dynamic contrast-enhanced MRI","volume":"50","author":"Dirix","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib13","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1200\/JCO.2005.04.6052","article-title":"Postradiotherapy neck dissection for lymph node-positive head and neck cancer: the use of computed tomography to manage the neck","volume":"24","author":"Liauw","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1756-6649-9-4","article-title":"Average arterial input function for quantitative dynamic contrast enhanced magnetic resonance imaging of neck nodal metastases","volume":"9","author":"Shukla-Dave","year":"2009","journal-title":"BMC Med Phys"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib15","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.ijrobp.2009.07.009","article-title":"Noninvasive assessment of tumor microenvironment using dynamic contrast enhanced MRI and [18F]fluoromisonidazole PET imaging in neck nodal metastases","volume":"77","author":"Jansen","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/mrm.21336","article-title":"On the identifiability of pharmacokinetic parameters in dynamic contrast-enhanced imaging","volume":"58","author":"Lopata","year":"2007","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib17","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/annonc\/mdn657","article-title":"The majority of transformed lymphomas have high standardized uptake values (SUVs) on positron emission tomography (PET) scanning similar to diffuse large B-cell lymphoma (DLBCL)","volume":"20","author":"Noy","year":"2009","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib18","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"Provencher","year":"1993","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib19","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1148\/radiol.2402050314","article-title":"1H MR spectroscopy of the brain: absolute quantification of metabolites","volume":"240","author":"Jansen","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S","article-title":"Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols","volume":"10","author":"Tofts","year":"1999","journal-title":"J\u00a0Magn Reson Imaging"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib21","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/mrm.21066","article-title":"Experimentalderived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI","volume":"56","author":"Parker","year":"2006","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib22","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.ultrasmedbio.2006.06.014","article-title":"Usefulness of standard deviation on the histogram of ultrasound as a quantitative value for hepatic parenchymal echo texture: preliminary study","volume":"32","author":"Lee","year":"2006","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1095-0397(99)00016-3","article-title":"Tumor treatment response based on visual and quantitative changes in global tumor glycolysis using PET-FDG Imaging. The visual response score and the change in total lesion glycolysis","volume":"2","author":"Larson","year":"1999","journal-title":"Clin Positron Imaging"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib24","series-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib25","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.acra.2009.06.001","article-title":"Proton and phosphorous MR spectroscopy in squamous cell carcinomas of the head and neck(1)","volume":"16","author":"Chawla","year":"2009","journal-title":"Acad Radiol"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib26","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/BF02984484","article-title":"Positron emission tomographic imaging with 11C-choline in differential diagnosis of head and neck tumors: comparison with [18F]FDG PET","volume":"18","author":"Khan","year":"2004","journal-title":"Ann Nucl Med"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib27","first-page":"912","article-title":"Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis","volume":"51","author":"Rock","year":"2002","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib28","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ijrobp.2007.10.055","article-title":"Correlation of positron emission tomography standard uptake value and pathologic specimen size in cancer of the head and neck","volume":"71","author":"Burri","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3174\/ajnr.A1817","article-title":"Prediction of response to chemoradiation therapy in squamous cell carcinomas of the head and neck using dynamic contrast-enhanced MR imaging","volume":"31","author":"Kim","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib30","doi-asserted-by":"crossref","first-page":"W156","DOI":"10.2214\/AJR.08.1429","article-title":"Prognostic value of [18F]FDG PET in patients with head and neck squamous cell cancer","volume":"192","author":"Torizuka","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.ijrobp.2010.11.022_bib31","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ijrobp.2007.11.030","article-title":"In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinoma","volume":"71","author":"Le","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610035704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610035704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T09:56:07Z","timestamp":1544003767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301610035704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0360301610035704"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2010.11.022","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}