{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:39:21Z","timestamp":1791074361378,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.ijrobp.2010.12.060","type":"journal-article","created":{"date-parts":[[2011,3,5]],"date-time":"2011-03-05T14:01:37Z","timestamp":1299333697000},"page":"e99-e105","source":"Crossref","is-referenced-by-count":69,"title":["Clinical Utility of 4D FDG-PET\/CT Scans in Radiation Treatment Planning"],"prefix":"10.1016","volume":"82","author":[{"given":"Michalis","family":"Aristophanous","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross I.","family":"Berbeco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H.","family":"Killoran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey T.","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Sher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elysia","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen B.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2010.12.060_bib1","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1056\/NEJMoa022136","article-title":"Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography","volume":"348","author":"Lardinois","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib2","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(02)08352-6","article-title":"Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer: The PLUS multicentre randomised trial","volume":"359","author":"van Tinteren","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0169-5002(99)00005-7","article-title":"Multimodality nuclear medicine imaging in three-dimensional radiation treatment planning for lung cancer: Challenges and prospects","volume":"23","author":"Munley","year":"1999","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0169-5002(97)00086-X","article-title":"The contribution of 18F-fluoro-2-deoxy-glucose positron emission tomographic imaging to radiotherapy planning in lung cancer","volume":"19","author":"Kiffer","year":"1998","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0167-8140(01)00470-4","article-title":"Radiotherapy treatment planning for patients with non-small cell lung cancer using positron emission tomography (PET)","volume":"62","author":"Erdi","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib6","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s002590000258","article-title":"Use of PET to monitor the response of lung cancer to radiation treatment","volume":"27","author":"Erdi","year":"2000","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib7","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1200\/JCO.2003.07.054","article-title":"Positron emission tomography is superior to computed tomography scanning for response-assessment after radical radiotherapy or chemotherapy in patients with non-small-cell lung cancer","volume":"21","author":"MacManus","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.radonc.2008.11.008","article-title":"Use of PET and PET\/CT for radiation therapy planning: IAEA expert report 2006-2007","volume":"91","author":"MacManus","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0360-3016(99)00061-9","article-title":"18F-Deoxyglucose positron emission tomography (FDG-PET) for the planning of radiotherapy in lung cancer: High impact in patients with atelectasis","volume":"44","author":"Nestle","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0360-3016(01)01824-7","article-title":"The impact of 18FDG-PET on target and critical organs in CT-based treatment planning of patients with poorly defined non-small-cell lung carcinoma: A prospective study","volume":"52","author":"Mah","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijrobp.2003.10.044","article-title":"Impact of FDG-PET on radiation therapy volume delineation in non-small cell lung cancer","volume":"59","author":"Bradley","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.critrevonc.2005.05.001","article-title":"Critical review of PET-CT for radiotherapy planning in lung cancer","volume":"56","author":"Senan","year":"2005","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib13","first-page":"4","article-title":"PET\/CT and radiotherapy","volume":"50","author":"Messa","year":"2006","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib14","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0360-3016(02)04609-6","article-title":"Can PET provide the 3D extent of tumor motion for individualized internal target volumes? A phantom study of the limitations of CT and the promise of PET","volume":"55","author":"Caldwell","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib15","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.1088\/0031-9155\/50\/24\/014","article-title":"Thresholding in PET images of static and moving targets","volume":"50","author":"Yaremko","year":"2005","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib16","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1088\/0031-9155\/53\/13\/018","article-title":"Evaluation of the combined effects of target size, respiratory motion and background activity on 3D and 4D PET\/CT images","volume":"53","author":"Park","year":"2008","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib17","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1118\/1.1943809","article-title":"Effect of motion on tracer activity determination in CT attenuation corrected PET images: A lung phantom study","volume":"32","author":"Pevsner","year":"2005","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib18","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1118\/1.1809778","article-title":"Four-dimensional (4D) PET\/CT imaging of the thorax","volume":"31","author":"Nehmeh","year":"2004","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib19","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1088\/0031-9155\/50\/7\/017","article-title":"Fusion of respiration-correlated PET and CT scans: Correlated lung tumour motion in anatomical and functional scans","volume":"50","author":"Wolthaus","year":"2005","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib20","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1109\/42.363108","article-title":"Accelerated image reconstruction using ordered subsets of projection data","volume":"13","author":"Hudson","year":"1994","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib21","first-page":"1342","article-title":"Comparison of different methods for delineation of 18F-FDG PET-positive tissue for target volume definition in radiotherapy of patients with non-small cell lung cancer","volume":"46","author":"Nestle","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijrobp.2003.10.045","article-title":"FDG-PET in radiotherapy treatment planning: Pandora\u2019s box?","volume":"59","author":"Paulino","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib23","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1118\/1.2791035","article-title":"A Gaussian mixture model for definition of lung tumor volumes in positron emission tomography","volume":"34","author":"Aristophanous","year":"2007","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib24","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1002\/(SICI)1097-0142(19971215)80:12+<2505::AID-CNCR24>3.0.CO;2-F","article-title":"Segmentation of lung lesion volume by adaptive positron emission tomography image thresholding","volume":"80","author":"Erdi","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0167-8140(01)00470-4","article-title":"Radiotherapy treatment planning for patients with non-small cell lung cancer using positron emission tomography (PET)","volume":"62","author":"Erdi","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib26","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.ijrobp.2004.06.254","article-title":"Defining a radiotherapy target with positron emission tomography","volume":"60","author":"Black","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib27","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1118\/1.2432404","article-title":"Fully automated segmentation of oncological PET volumes using a combined multiscale and statistical model","volume":"34","author":"Montgomery","year":"2007","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib28","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1118\/1.2779941","article-title":"Internal-external correlation investigations of respiratory induced motion of lung tumors","volume":"34","author":"Ionascu","year":"2007","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2010.12.060_bib29","unstructured":"Aristophanous M, Yap, JT, Killoran JH, et al. 4D PET\u2014Implications for dose painting of high uptake regions. Int J Radiat Oncol Biol Phys. 2010 Oct 13 [Epub ahead of print]."},{"key":"10.1016\/j.ijrobp.2010.12.060_bib30","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.radonc.2006.02.015","article-title":"Changes in the respiratory pattern during radiotherapy for cancer in the lung","volume":"78","author":"Hugo","year":"2006","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301611000629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301611000629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T01:19:57Z","timestamp":1560043197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301611000629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0360301611000629"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2010.12.060","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}