{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:07:59Z","timestamp":1791281279392,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.ijrobp.2011.03.006","type":"journal-article","created":{"date-parts":[[2011,5,23]],"date-time":"2011-05-23T21:47:27Z","timestamp":1306187247000},"page":"1837-1844","source":"Crossref","is-referenced-by-count":130,"title":["Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Predictor of Outcome in Head-and-Neck Squamous Cell Carcinoma Patients With Nodal Metastases"],"prefix":"10.1016","volume":"82","author":[{"given":"Amita","family":"Shukla-Dave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobus F.A.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard T.","family":"Thaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda E.","family":"Stambuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Fury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal G.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre L.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasan","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Koutcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2011.03.006_bib1","series-title":"Cancer facts and figures 2010","year":"2010"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib2","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib3","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib4","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1200\/JCO.2006.07.1464","article-title":"Head and neck cancer: Recent advances and new standards of care","volume":"24","author":"Forastiere","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib5","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMoa070956","article-title":"Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer","volume":"357","author":"Posner","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib6","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.ejso.2009.06.010","article-title":"Clinicopathologic risk factors for distant metastases from head and neck squamous cell carcinomas","volume":"35","author":"Li","year":"2009","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/CCO.0b013e32832a6e05","article-title":"Head and neck cancer emerging strategies: Advances and new challenges","volume":"21","author":"Awada","year":"2009","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib8","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/hed.1102","article-title":"Prediction of survival in patients with head and neck cancer","volume":"23","author":"Baatenburg de Jong","year":"2001","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib9","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/00004728-199901000-00011","article-title":"Tumor volume: An independent predictor of outcome for laryngeal cancer","volume":"23","author":"Mukherji","year":"1999","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0167-8140(99)00119-X","article-title":"Prognostic impact of total tumor volume and hemoglobin concentration on the outcome of patients with advanced head and neck cancer after concomitant boost radiochemotherapy","volume":"53","author":"Rudat","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib11","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/00000421-200212000-00012","article-title":"Predictive value of P53, BCL-2, and BAX in advanced head and neck carcinoma","volume":"25","author":"Casado","year":"2002","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib12","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1200\/JCO.2002.06.161","article-title":"Alteration of p53 pathway in squamous cell carcinoma of the head and neck: Impact on treatment outcome in patients treated with larynx preservation intent","volume":"20","author":"Osman","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/1097-0347(200102)23:2<147::AID-HED1010>3.0.CO;2-#","article-title":"Potential molecular prognostic markers in head and neck squamous cell carcinomas","volume":"23","author":"Quon","year":"2001","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib14","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/(SICI)1097-0215(19990420)84:2<188::AID-IJC16>3.0.CO;2-1","article-title":"Epidermal growth factor receptor expression in primary laryngeal cancer: An independent prognostic factor of neck node relapse","volume":"84","author":"Almadori","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djn011","article-title":"Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial","volume":"100","author":"Fakhry","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib16","first-page":"2513","article-title":"Tumor microcirculation evaluated by dynamic magnetic resonance imaging predicts therapy outcome for primary rectal carcinoma","volume":"61","author":"Devries","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib17","first-page":"3598","article-title":"Uterine cervical carcinoma: Comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival","volume":"58","author":"Hawighorst","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib18","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1200\/JCO.2006.06.8080","article-title":"Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker","volume":"24","author":"Hylton","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib19","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/jmri.21778","article-title":"Predicting survival and early clinical response to primary chemotherapy for patients with locally advanced breast cancer using DCE-MRI","volume":"29","author":"Johansen","year":"2009","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib20","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3174\/ajnr.A1817","article-title":"Prediction of response to chemoradiation therapy in squamous cell carcinomas of the head and neck using dynamic contrast-enhanced MR imaging","volume":"31","author":"Kim","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1200\/JCO.2009.23.8584","article-title":"Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01","volume":"28","author":"Machiels","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/mrm.1910330408","article-title":"Pharmacokinetic mapping of the breast: A new method for dynamic MR mammography","volume":"33","author":"Hoffmann","year":"1995","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<233::AID-JMRI3>3.0.CO;2-M","article-title":"Multicompartment analysis of gadolinium chelate kinetics: Blood-tissue exchange in mammary tumors as monitored by dynamic MR imaging","volume":"10","author":"Port","year":"1999","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S","article-title":"Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: Standardized quantities and symbols","volume":"10","author":"Tofts","year":"1999","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/157340507780619179","article-title":"Dynamic contrast enhanced magnetic resonance imaging in oncology: Theory, data acquisition, analysis, and examples","volume":"3","author":"Yankeelov","year":"2007","journal-title":"Curr Med Imag Rev"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib26","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.ijrobp.2008.08.024","article-title":"Early prediction of outcome in advanced head-and-neck cancer based on tumor blood volume alterations during therapy: A prospective study","volume":"72","author":"Cao","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib27","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ijrobp.2007.03.013","article-title":"Concurrent chemotherapy and intensity-modulated radiotherapy for locoregionally advanced laryngeal and hypopharyngeal cancers","volume":"69","author":"Lee","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib28","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.ijrobp.2007.07.2351","article-title":"Intensity-modulated radiotherapy for head and neck cancer of unknown primary: Toxicity and preliminary efficacy","volume":"70","author":"Klem","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1756-6649-9-4","article-title":"Average arterial input function for quantitative dynamic contrast enhanced magnetic resonance imaging of neck nodal metastases","volume":"9","author":"Shukla-Dave","year":"2009","journal-title":"BMC Med Phys"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib30","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.ijrobp.2009.07.009","article-title":"Noninvasive assessment of tumor microenvironment using dynamic contrast-enhanced magnetic resonance imaging and (18)f-fluoromisonidazole positron emission tomography imaging in neck nodal metastases","volume":"77","author":"Jansen","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib31","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.ultrasmedbio.2006.06.014","article-title":"Usefulness of standard deviation on the histogram of ultrasound as a quantitative value for hepatic parenchymal echo texture; Preliminary study","volume":"32","author":"Lee","year":"2006","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib32","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1067\/mhn.2001.114794","article-title":"Association of 8p23 deletions with poor survival in head and neck cancer","volume":"124","author":"Bockmuhl","year":"2001","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib33","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.neo.7900037","article-title":"Causes and effects of heterogeneous perfusion in tumors","volume":"1","author":"Gillies","year":"1999","journal-title":"Neoplasia"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib34","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1158\/1078-0432.CCR-07-0238","article-title":"Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging","volume":"13","author":"Jackson","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib35","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.ijrobp.2005.04.052","article-title":"Dynamic contrast-enhanced magnetic resonance imaging of radiation therapy-induced microcirculation changes in rectal cancer","volume":"63","author":"de Lussanet","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib36","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/00004728-199907000-00024","article-title":"Heterogeneity analysis of Gd-DTPA uptake: Improvement in breast lesion differentiation","volume":"23","author":"Issa","year":"1999","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib37","first-page":"7","article-title":"Abnormalities in the recirculation phase of contrast agent bolus passage in cerebral gliomas: Comparison with relative blood volume and tumor grade","volume":"23","author":"Jackson","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib38","first-page":"853","article-title":"Do cerebral blood volume and contrast transfer coefficient predict prognosis in human glioma?","volume":"27","author":"Mills","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"issue":"Suppl 3","key":"10.1016\/j.ijrobp.2011.03.006_bib39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1634\/theoncologist.13-S3-21","article-title":"Hypoxia and aggressive tumor phenotype: Implications for therapy and prognosis","volume":"13","author":"Vaupel","year":"2008","journal-title":"Oncologist"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib40","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0360-3016(97)00101-6","article-title":"Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck","volume":"38","author":"Brizel","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib41","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/archoto.2009.123","article-title":"Comparison of clinical and pathological staging in head and neck squamous cell carcinoma: Results from Intergroup Study ECOG 4393\/RTOG 9614","volume":"135","author":"Koch","year":"2009","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib42","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000064313","article-title":"Prognostic factors in squamous cell carcinoma of the head and neck","volume":"25","author":"Wendt","year":"2002","journal-title":"Onkologie"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib43","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/CCO.0b013e32832a2322","article-title":"Functional imaging of head and neck cancers","volume":"21","author":"Emonts","year":"2009","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib44","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0360-3016(03)00764-8","article-title":"Tumor perfusion rate determined noninvasively by dynamic computed tomography predicts outcome in head-and-neck cancer after radiotherapy","volume":"57","author":"Hermans","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib45","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.ijrobp.2008.05.004","article-title":"Pretreatment primary tumor SUVmax measured by FDG-PET and pathologic tumor depth predict for poor outcomes in patients with oral cavity squamous cell carcinoma and pathologically positive lymph nodes","volume":"73","author":"Liao","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib46","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/hed.20942","article-title":"Pretreatment FDG-PET standardized uptake value as a prognostic factor for outcome in head and neck cancer","volume":"31","author":"Machtay","year":"2009","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib47","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.oraloncology.2008.07.009","article-title":"FDG-PET predicts survival and distant metastasis in oral squamous cell carcinoma","volume":"45","author":"Suzuki","year":"2009","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2011.03.006_bib48","doi-asserted-by":"crossref","first-page":"7041","DOI":"10.1158\/0008-5472.CAN-05-0674","article-title":"Expanding the use of magnetic resonance in the assessment of tumor response to therapy: Workshop report","volume":"65","author":"Evelhoch","year":"2005","journal-title":"Cancer Res"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301611004597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301611004597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T09:22:58Z","timestamp":1543742578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301611004597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0360301611004597"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2011.03.006","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}