{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:27:43Z","timestamp":1778394463787,"version":"3.51.4"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.ijrobp.2012.02.053","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T00:16:13Z","timestamp":1334276173000},"page":"223-229","source":"Crossref","is-referenced-by-count":11,"title":["Sex-dependent Differences in Intestinal Tumorigenesis Induced in Apc1638N\/+ Mice by Exposure to \u03b3 Rays"],"prefix":"10.1016","volume":"85","author":[{"given":"Daniela","family":"Trani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Hyun","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaskar","family":"Kallakury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan P.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Albert J.","family":"Fornace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2012.02.053_bib1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrc3069","article-title":"Assessing the risk of second malignancies after modern radiotherapy","volume":"11","author":"Newhauser","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2008.12.016","article-title":"Can we reduce the incidence of second primary malignancies occurring after radiotherapy? A critical review","volume":"91","author":"Tubiana","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib3","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/jnci\/djq238","article-title":"Subsequent neoplasms in 5-year survivors of childhood cancer: The Childhood Cancer Survivor Study","volume":"102","author":"Friedman","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1667\/RR0763.1","article-title":"Solid cancer incidence in atomic bomb survivors: 1958-1998","volume":"168","author":"Preston","year":"2007","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib5","doi-asserted-by":"crossref","first-page":"8969","DOI":"10.1073\/pnas.91.19.8969","article-title":"A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors","volume":"91","author":"Fodde","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00411-010-0292-2","article-title":"Enhanced intestinal tumor multiplicity and grade in\u00a0vivo after HZE exposure: mouse models for space radiation risk estimates","volume":"49","author":"Trani","year":"2010","journal-title":"Radiat Environ Biophys"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib7","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/carcin\/18.11.2197","article-title":"Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays","volume":"18","author":"van der Houven van Oordt","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib8","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1667\/RR0869.1","article-title":"X radiation up-regulates the occurrence and the multiplicity of invasive carcinomas in the intestinal tract of Apc(min\/+) mice","volume":"168","author":"Nakayama","year":"2007","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib9","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/carcin\/bgp132","article-title":"Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min\/+) mice","volume":"30","author":"Cleveland","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1440-1746.2009.05992.x","article-title":"Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer","volume":"25","author":"Koo","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/ijc.26026","article-title":"The effect of estrogen versus combined estrogen-progestogen therapy on the risk of colorectal cancer","volume":"130","author":"Lin","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib12","first-page":"2547","article-title":"Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis","volume":"61","author":"Weyant","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-59745-249-6_7","article-title":"Detection of beta-catenin localization by immunohistochemistry","volume":"468","author":"Barker","year":"2008","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nrc722","article-title":"Second cancers in survivors of childhood cancer","volume":"2","author":"Bhatia","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)81333-1","article-title":"Lessons from hereditary colorectal cancer","volume":"87","author":"Kinzler","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1124\/mi.3.5.281","article-title":"Estrogen signaling: a subtle balance between ER alpha and ER beta","volume":"3","author":"Matthews","year":"2003","journal-title":"Mol Interv"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib17","first-page":"194","article-title":"Estrogens, MSI and Lynch syndrome-associated tumors","volume":"1796","author":"Ferreira","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.genm.2008.07.005","article-title":"Sex-specific differences in the expression levels of estrogen receptor subtypes in colorectal cancer","volume":"5","author":"Nussler","year":"2008","journal-title":"Gend Med"},{"key":"10.1016\/j.ijrobp.2012.02.053_bib19","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1677\/erc.1.00800","article-title":"Loss of ERbeta expression as a common step in estrogen-dependent tumor progression","volume":"11","author":"Bardin","year":"2004","journal-title":"Endocr Relat Cancer"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301612003227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301612003227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T04:53:45Z","timestamp":1543035225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301612003227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0360301612003227"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2012.02.053","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}