{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:09:53Z","timestamp":1789171793645,"version":"build-2803163510"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.ijrobp.2012.03.065","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T03:47:15Z","timestamp":1346125635000},"page":"e181-e185","source":"Crossref","is-referenced-by-count":29,"title":["Mean Absorbed Dose to the Anal-Sphincter Region and Fecal Leakage among Irradiated Prostate Cancer Survivors"],"prefix":"10.1016","volume":"84","author":[{"given":"David","family":"Alsadius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hedelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lundstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niclas","family":"Pettersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrica","family":"Wilder\u00e4ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Steineck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2012.03.065_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.radonc.2010.12.004","article-title":"Faecal incontinence following radiotherapy for prostate cancer: a systematic review","volume":"98","author":"M\u00e6da","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.radonc.2011.06.010","article-title":"Tobacco smoking and long-lasting symptoms after radiotherapy for prostate cancer","volume":"101","author":"Alsadius","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib3","series-title":"Prescribing, Recording, and Reporting Photon Beam Therapy","year":"1993"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib4","series-title":"Prescribing, Recording, and Reporting Photon Beam Therapy (Supplement to ICRU Report 50)","year":"1993"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3109\/02841861003702536","article-title":"Variation in position and volume of organs in the small pelvis","volume":"49","author":"Waldenstr\u00f6m","year":"2009","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1080\/02841860260088782","article-title":"Symptom documentation in cancer survivors as a basis for therapy modifications","volume":"41","author":"Steineck","year":"2002","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib7","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.ijrobp.2007.07.2354","article-title":"Clinical and dosimetric predictors of late rectal syndrome after 3D-CRT for localized prostate cancer: preliminary results of a multicenter prospective study","volume":"70","author":"Fiorino","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib8","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.ijrobp.2004.07.715","article-title":"Acute and late complications after radiotherapy for prostate cancer: results of a multicenter randomized trial comparing 68 Gy to 78 Gy","volume":"61","author":"Peeters","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/02841860310020933","article-title":"Dose to the anal sphincter region and risk of fecal leakage","volume":"43","author":"Al-Abany","year":"2004","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib10","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.ijrobp.2004.07.706","article-title":"Toward a definition of a threshold for harmless doses to the anal-sphincter region and the rectum","volume":"61","author":"Al-Albany","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.radonc.2009.09.004","article-title":"Clinical and dosimetric predictors of late rectal toxicity after conformal radiation for localized prostate cancer: results of a large multicenter observational study","volume":"93","author":"Fellin","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib12","unstructured":"Fiorino C, Rancati T, Fellin G, et\u00a0al. Late fecal incontinence after high-dose radiotherapy for prostate cancer: better prediction using longitudinal definitions. Int J Radiat Oncol Biol Phys. In press."},{"key":"10.1016\/j.ijrobp.2012.03.065_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.radonc.2003.07.002","article-title":"Association of anorectal dose\u2013volume histograms and impaired fecal continence after 3D conformal radiotherapy for carcinoma of the prostate","volume":"69","author":"Vordemark","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib14","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ijrobp.2009.02.025","article-title":"Dose-volume constraints to reduce rectal side effects from prostate radiotherapy: evidence from mrc rt01 trial ISRCTN 47772397","volume":"76","author":"Gulliford","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.radonc.2007.06.013","article-title":"Late radiotherapy-induced lower intestinal toxicity (RILIT) of intensity-modulated radiotherapy for prostate cancer: the need for adapting toxicity scales and the appearance of the sigmoid colon as co-responsible organ for lower intestinal toxicity","volume":"84","author":"Fonteyne","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib16","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ijrobp.2005.10.002","article-title":"Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer","volume":"64","author":"Peeters","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2004.07.020","article-title":"Gastro-intestinal and genito-urinary morbidity after 3D conformal radiotherapy of prostate cancer: observations of a randomized trial","volume":"73","author":"Koper","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib18","doi-asserted-by":"crossref","unstructured":"Lundby L, Krogh K, Jensen VJ, et\u00a0al. Long-term anorectal dysfunction after postoperative radiotherapy for rectal cancer. 2005;48:1343-1349.","DOI":"10.1007\/s10350-005-0049-1"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.radonc.2009.05.021","article-title":"Novel insights into pathological changes in muscular arteries of radiotherapy patients","volume":"92","author":"Russell","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2012.03.065_bib20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/02841860600649293","article-title":"A hierarchical step-model for causation of bias-evaluating cancer treatment with epidemiological methods","volume":"45","author":"Steineck","year":"2006","journal-title":"Acta Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301612004968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301612004968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T04:57:28Z","timestamp":1562129848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301612004968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0360301612004968"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2012.03.065","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}