{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:04:39Z","timestamp":1771664679404,"version":"3.50.1"},"reference-count":13,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.ijrobp.2012.10.042","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T20:24:00Z","timestamp":1355948640000},"page":"1246-1253","source":"Crossref","is-referenced-by-count":43,"title":["Age and Comorbid Illness Are Associated With Late Rectal Toxicity Following Dose-Escalated Radiation Therapy for Prostate Cancer"],"prefix":"10.1016","volume":"85","author":[{"given":"Daniel A.","family":"Hamstra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt H.","family":"Stenmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Litzenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Skyler","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesel","family":"Albrecht-Unger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Donaghy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Phelps","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Blas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schuyler","family":"Halverson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix Y.","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3 Suppl","key":"10.1016\/j.ijrobp.2012.10.042_bib1","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/j.ijrobp.2009.03.078","article-title":"Radiation dose volume effects in radiation-induced rectal injury","volume":"76","author":"Michalski","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0360-3016(90)90262-I","article-title":"Late radiation damage in prostate cancer patients treated by high dose external radiotherapy in relation to rectal dose","volume":"18","author":"Smit","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib3","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.ijrobp.2007.11.044","article-title":"Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity modulated radiotherapy for localized prostate cancer","volume":"70","author":"Zelefsky","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0360-3016(99)00560-X","article-title":"Late rectal toxicity after 3D-conformal radiation therapy of prostate cancer: Multivariate analysis and dose-response","volume":"47","author":"Skwarchuk","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"suppl3","key":"10.1016\/j.ijrobp.2012.10.042_bib5","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues","volume":"76","author":"Bentzen","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib7","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0360-3016(03)00569-8","article-title":"Dose escalation for localized prostate cancer: substantial benefit observed with 3D conformal therapy","volume":"57","author":"Symon","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib8","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib9","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.3109\/0284186X.2010.509736","article-title":"Normal tissue complication probability (NTCP) modeling of late rectal bleeding following external beam radiotherapy for prostate cancer: a test of the QUANTEC-recommended NTCP model","volume":"49","author":"Liu","year":"2010","journal-title":"Acta Oncologica"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib10","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.ijrobp.2010.01.069","article-title":"Late rectal toxicity on RTOG 94-06: analysis using a mixture Lyman model","volume":"78","author":"Tucker","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib11","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ijrobp.2011.11.073","article-title":"Do intermediate radiation doses contribute to late rectal toxicity? An analysis of data from radiation therapy oncology group protocol 94-06","volume":"84","author":"Tucker","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib12","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.eururo.2011.05.052","article-title":"Late gastrointestinal toxicities following radiation therapy for prostate cancer","volume":"60","author":"Kim","year":"2011","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2012.10.042_bib13","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.ijrobp.2009.02.026","article-title":"External beam radiotherapy for prostate cancer patients on anticoagulation therapy: how significant is the bleeding toxicity?","volume":"76","author":"Choe","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030161203742X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030161203742X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T04:21:32Z","timestamp":1540009292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036030161203742X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S036030161203742X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2012.10.042","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}