{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:38:47Z","timestamp":1791211127577,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.ijrobp.2013.05.017","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T02:17:53Z","timestamp":1371781073000},"page":"120-126","source":"Crossref","is-referenced-by-count":69,"title":["Proton Radiation Therapy for Pediatric Medulloblastoma and Supratentorial Primitive Neuroectodermal Tumors: Outcomes for Very Young Children Treated With Upfront Chemotherapy"],"prefix":"10.1016","volume":"87","author":[{"given":"Rachel B.","family":"Jimenez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Depauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret B.","family":"Pulsifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ebb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara C.","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Tarbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torunn I.","family":"Yock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2013.05.017_bib1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/mpo.10121","article-title":"Incidence and trends in pediatric malignancies medulloblastoma\/primitive neuroectodermal tumor: A SEER update. Surveillance Epidemiology and End Results","volume":"39","author":"McNeil","year":"2002","journal-title":"Pediatr Oncol"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib2","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1200\/JCO.2010.30.2299","article-title":"Survival and prognostic factors of early childhood medulloblastoma: An international meta-analysis","volume":"28","author":"Rutkowski","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib3","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1002\/(SICI)1097-0142(20000501)88:9<2189::AID-CNCR27>3.0.CO;2-G","article-title":"Outcome for children with supratentorial primitive neuroectodermal tumors treated with surgery, radiation, and chemotherapy","volume":"88","author":"Reddy","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11060-007-9440-1","article-title":"Supratentorial primitive neuroectodermal tumors: A Canadian pediatric brain tumor consortium report","volume":"86","author":"Johnston","year":"2008","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/MOP.0b013e32834255e9","article-title":"Neurocognitive outcome in survivors of pediatric cancer","volume":"23","author":"Winick","year":"2011","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib6","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1056\/NEJMoa042176","article-title":"Treatment of early childhood medulloblastoma by postoperative chemotherapy alone","volume":"352","author":"Rutkowski","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1470-2045(05)70252-7","article-title":"Treatment of medulloblastoma with postoperative chemotherapy alone: An SFOP prospective trial in young children","volume":"6","author":"Grill","year":"2005","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1215\/15228517-2008-084","article-title":"Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy","volume":"11","author":"Rutkowski","year":"2009","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib9","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1200\/JCO.2010.34.4341","article-title":"Induction chemotherapy and conformal radiation therapy for very young children with nonmetastatic medulloblastoma: Children's Oncology Group study P9934","volume":"30","author":"Ashley","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib10","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0360-3016(03)01574-8","article-title":"Advantage of protons compared to conventional X-ray or IMRT in the treatment of a pediatric patient with medulloblastoma","volume":"58","author":"St. Clair","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib11","series-title":"The Bayley Scales of Infant Development","author":"Bayley","year":"1993"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib12","series-title":"The Wechsler Preschool and Primary Scale of Intelligence","author":"Wechsler","year":"2002"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib13","series-title":"The Wechsler Intelligence Scale for Children","author":"Wechsler","year":"2003"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib14","series-title":"Scales of Independent Behavior-Revised","author":"Bruininks","year":"1996"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1748-717X-6-58","article-title":"Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy","volume":"6","author":"Moeller","year":"2011","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib16","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1200\/JCO.1988.6.6.996","article-title":"Eight drugs in one day chemotherapy in children with brain tumors: A critical toxicity appraisal","volume":"6","author":"Geyer","year":"1988","journal-title":"J Clin Oncol"},{"issue":"2 Suppl.","key":"10.1016\/j.ijrobp.2013.05.017_bib17","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1016\/j.ijrobp.2011.06.230","article-title":"Results from a prospective trial of proton radiotherapy for medulloblastoma: Clinical outcomes including hearing and neurocognitive (Abstr.)","volume":"81","author":"Yock","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib18","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/S0959-8049(98)00212-3","article-title":"Long-term neuro-endocrine sequelae after treatment for childhood medulloblastoma","volume":"34","author":"Heikens","year":"1998","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib19","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1200\/JCO.2011.37.9453","article-title":"Growth hormone secretion after conformal radiation therapy in pediatric patients with localized brain tumors","volume":"29","author":"Merchant","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2013.05.017_bib20","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0360-3016(02)02744-X","article-title":"Hypothyroidism in children with medulloblastoma: A comparison of 3600 and 2340 cGy craniospinal radiotherapy","volume":"53","author":"Paulino","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030161300549X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030161300549X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T20:40:12Z","timestamp":1563223212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036030161300549X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S036030161300549X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2013.05.017","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}