{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:56:12Z","timestamp":1791068172581,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.ijrobp.2013.07.040","type":"journal-article","created":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T17:16:34Z","timestamp":1378833394000},"page":"676-682","source":"Crossref","is-referenced-by-count":73,"title":["Parotid Glands Dose\u2013Effect Relationships Based on Their Actually Delivered Doses: Implications for Adaptive Replanning in Radiation Therapy of Head-and-Neck Cancer"],"prefix":"10.1016","volume":"87","author":[{"given":"Klaudia U.","family":"Hunter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Vineberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"McShan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan E.","family":"Antonuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Cornwall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew J.","family":"Schipper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Balter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Eisbruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2013.07.040_bib1","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.ijrobp.2003.12.024","article-title":"Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT\/linear accelerator system","volume":"59","author":"Barker","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.ijrobp.2007.01.030","article-title":"Spatial and dosimetric variability of organs at risk in head-and-neck intensity-modulated radiotherapy","volume":"68","author":"Robar","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib3","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.ijrobp.2009.04.005","article-title":"Weekly volume and dosimetric changes during chemoradiotherapy with intensity-modulated radiation therapy for head and neck cancer: A prospective observational study","volume":"76","author":"Bhide","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib4","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.ijrobp.2007.07.2345","article-title":"Parotid gland dose in intensity-modulated radiotherapy for head and neck cancer: Is what you plan what you get?","volume":"69","author":"O\u2019Daniel","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ijrobp.2005.07.957","article-title":"Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer","volume":"64","author":"Hansen","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib6","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.ijrobp.2009.04.047","article-title":"Adaptive replanning strategies accounting for shrinkage in head and neck IMRT","volume":"75","author":"Wu","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl. 1","key":"10.1016\/j.ijrobp.2013.07.040_bib7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2005.07.011","article-title":"Adaptive planning and delivery to account for anatomical changes induced by radiation therapy of head and neck cancer [Abstract 5]","volume":"63","author":"Sharpe","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib8","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ijrobp.2011.08.017","article-title":"Adaptive radiotherapy for head and neck cancer: Initial clinical outcomes from a prospective trial","volume":"83","author":"Schwartz","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.radonc.2012.11.005","article-title":"Volume and dosimetric changes and clinical experience of a two-step adaptive IMRT for head and neck cancer","volume":"106","author":"Nishi","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.radonc.2011.06.011","article-title":"Adaptive functional image-guided IMRT in pharyngo-laryngeal cancer","volume":"101","author":"Castadot","year":"2011","journal-title":"Radiother Oncol"},{"issue":"Suppl. 3","key":"10.1016\/j.ijrobp.2013.07.040_bib11","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.ijrobp.2009.06.090","article-title":"Radiotherapy dose-volume effects on salivary gland function","volume":"76","author":"Deasy","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","article-title":"Dose, volume, and function relationships in parotid salivary glands following conformal and intensity modulated radiotherapy of head and neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijrobp.2009.07.1708","article-title":"Parotid gland function after radiotherapy: The combined Michigan and Utrecht experience","volume":"78","author":"Dijkema","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.ijrobp.2004.12.015","article-title":"Long-term parotid function after radiotherapy","volume":"62","author":"Braam","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib15","first-page":"548","article-title":"Estimation of delivered dose in radiotherapy: The influence of registration uncertainties","volume":"14","author":"Risholm","year":"2011","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib16","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1118\/1.3013563","article-title":"Objective assessment of deformable image registration in radiotherapy","volume":"35","author":"Kashani","year":"2008","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib17","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijrobp.2011.09.004","article-title":"Reducing xerostomia after chemo-IMRT for head-and-neck cancer: beyond sparing the parotid glands","volume":"83","author":"Little","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib18","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0360-3016(01)01512-7","article-title":"Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer","volume":"50","author":"Eisbruch","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib19","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ijrobp.2011.04.020","article-title":"Treatment planning constraints to avoid xerostomia","volume":"82","author":"Moiseenko","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ijrobp.2007.12.033","article-title":"Dose-effect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy","volume":"72","author":"Murdoch-Kinch","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib21","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.ijrobp.2003.09.021","article-title":"Scintigraphic assessment of parotid gland function","volume":"58","author":"Roesink","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib22","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1259\/bjr\/32038456","article-title":"Interobserver variation in parotid gland delineation","volume":"85","author":"Loo","year":"2012","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2013.07.040_bib23","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.ijrobp.2006.11.010","article-title":"Positioning accuracy of CBCT in combination with hexapod robot treatment table","volume":"67","author":"Meyer","year":"2007","journal-title":"Int J Rad Onc Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030161302912X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030161302912X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T01:56:24Z","timestamp":1539395784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036030161302912X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S036030161302912X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2013.07.040","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}