{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:41:41Z","timestamp":1791196901866,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.ijrobp.2013.09.003","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T17:16:48Z","timestamp":1382548608000},"page":"1171-1178","source":"Crossref","is-referenced-by-count":76,"title":["Mesenchymal Stem Cells Retain Their Defining Stem Cell Characteristics After Exposure to Ionizing Radiation"],"prefix":"10.1016","volume":"87","author":[{"given":"Nils H.","family":"Nicolay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Wirkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy","family":"Trinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonevisay","family":"Sisombath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Saffrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2013.09.003_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/stem.559","article-title":"Concise review: Dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?","volume":"29","author":"Klopp","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib3","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1084\/jem.20091046","article-title":"Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow","volume":"206","author":"Morikawa","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib4","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/14653240802217011","article-title":"Heterogeneity of mesenchymal stromal cell preparations","volume":"10","author":"Ho","year":"2008","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2174\/138945012799499749","article-title":"Molecular targeting regulation of proliferation and differentiation of the bone marrow-derived mesenchymal stem cells or mesenchymal stromal cells","volume":"13","author":"Chen","year":"2012","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.32607\/20758251-2011-3-4-30-37","article-title":"Mesenchymal stem cells in tissue growth and repair","volume":"3","author":"Kalinina","year":"2011","journal-title":"Acta Naturae"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib7","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/CIRCRESAHA.111.243147","article-title":"Mesenchymal stem cells: Biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease","volume":"109","author":"Williams","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12272-012-0201-0","article-title":"Perspectives on mesenchymal stem cells: Tissue repair, immune modulation, and tumor homing","volume":"35","author":"Hong","year":"2012","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib9","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1667\/RR2295.1","article-title":"Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma","volume":"174","author":"Lynam-Lennon","year":"2010","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib10","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1182\/blood.V86.1.122.bloodjournal861122","article-title":"Variations in radiation sensitivity and repair among different hematopoietic stem cell subsets following fractionated irradiation","volume":"86","author":"Down","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib11","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.exphem.2005.07.003","article-title":"Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood","volume":"33","author":"Wagner","year":"2005","journal-title":"Exp Hematol"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib12","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1172\/JCI26772","article-title":"Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair","volume":"116","author":"Maes","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/09553002.2012.666001","article-title":"Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments","volume":"88","author":"Cmielova","year":"2012","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib14","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s00018-012-1224-x","article-title":"Silencing of RB1 but not of RB2\/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells","volume":"70","author":"Alessio","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/pros.20316","article-title":"Integrin-dependent amplification of the G2 arrest induced by ionizing radiation","volume":"66","author":"Kremer","year":"2006","journal-title":"Prostate"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib16","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.2307\/3579808","article-title":"Radiation and the G2 phase of the cell cycle","volume":"150","author":"Hwang","year":"1998","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib17","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.151.3709.459","article-title":"Serum concentration: Effects on cycle and x-ray sensitivity of mammalian cells","volume":"151","author":"Hahn","year":"1966","journal-title":"Science"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib18","first-page":"4915","article-title":"A radioresistant variant derived from a human neuroblastoma cell line is less prone to radiation-induced apoptosis","volume":"55","author":"Russell","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib19","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/stem.1336","article-title":"Differentiation-related response to DNA breaks in human mesenchymal stem cells","volume":"31","author":"Oliver","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib20","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.4161\/cc.10.21.17972","article-title":"Activation of DNA damage response pathways in human mesenchymal stem cells exposed to cisplatin or gamma-irradiation","volume":"10","author":"Prendergast","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/stem.1222","article-title":"Multiple facets of the DNA damage response contribute to the radio-resistance of mouse mesenchymal stromal cell lines","volume":"31","author":"Sugrue","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib22","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.stem.2012.05.015","article-title":"Mesenchymal stromal cells: New directions","volume":"10","author":"Keating","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib23","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1582-4934.2011.01383.x","article-title":"Mesenchymal stem cells show radioresistance in\u00a0vivo","volume":"16","author":"Singh","year":"2012","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib24","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0531-5565(00)00168-6","article-title":"Spontaneous and radiation-induced differentiationof fibroblasts","volume":"35","author":"Herskind","year":"2000","journal-title":"Exp Gerontol"},{"issue":"Suppl 1","key":"10.1016\/j.ijrobp.2013.09.003_bib25","first-page":"44","article-title":"Survival, differentiation and collagen secretion of human fibroblasts after irradiation with carbon ions and x-rays","volume":"14","author":"Fournier","year":"1998","journal-title":"Phys Med"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1399-3046.2006.00663.x","article-title":"The effects of various irradiation doses on the growth and differentiation of marrow-derived human mesenchymal stromal cells","volume":"11","author":"Li","year":"2007","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/8756-3282(92)90364-3","article-title":"Characterization of cells with osteogenic potential from human marrow","volume":"13","author":"Haynesworth","year":"1992","journal-title":"Bone"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib28","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1634\/stemcells.2005-0319","article-title":"Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors","volume":"24","author":"Honczarenko","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.ijrobp.2013.09.003_bib29","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1073\/pnas.1015350108","article-title":"Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells","volume":"108","author":"Cao","year":"2011","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301613030897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301613030897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T16:40:57Z","timestamp":1596732057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301613030897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0360301613030897"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2013.09.003","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}