{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T22:06:50Z","timestamp":1773526010659,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.ijrobp.2014.01.056","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T01:32:27Z","timestamp":1397093547000},"page":"67-74","source":"Crossref","is-referenced-by-count":33,"title":["Survival and Neurocognitive Outcomes After Cranial or Craniospinal Irradiation Plus Total-Body Irradiation Before Stem Cell Transplantation in Pediatric Leukemia Patients With Central Nervous System Involvement"],"prefix":"10.1016","volume":"89","clinical-trial-number":[{"clinical-trial-number":"nct00096135","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Susan M.","family":"Hiniker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajni","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie A.","family":"Modlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine C.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy P.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Million","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen F.","family":"Kiamanesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah S.","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2014.01.056_bib1","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1200\/JCO.2011.37.8018","article-title":"Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the Children's Oncology Group","volume":"30","author":"Hunger","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/08880011003758422","article-title":"Controversies in the management of central nervous system leukemia","volume":"27","author":"Barredo","year":"2010","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/08880010490277097","article-title":"The prognosis and survival of childhood acute lymphoblastic leukemia with central nervous system relapse","volume":"21","author":"Unal","year":"2004","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib4","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1200\/JCO.2005.03.3373","article-title":"Isolated CNS relapse of acute lymphoblastic leukemia treated with intensive systemic chemotherapy and delayed CNS radiation: A Pediatric Oncology Group study","volume":"24","author":"Barredo","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.bbmt.2008.03.011","article-title":"Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system","volume":"14","author":"Harker-Murray","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib6","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1200\/JCO.2000.18.2.340","article-title":"Comparison of preparative regimens in transplants for children with acute lymphoblastic leukemia","volume":"18","author":"Davies","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib7","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/1097-0142(19891101)64:9<1796::AID-CNCR2820640907>3.0.CO;2-7","article-title":"Central nervous system relapses after bone marrow transplantation for acute lymphoblastic leukemia in remission","volume":"64","author":"Ganem","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib8","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.bbmt.2008.07.002","article-title":"Central nervous system relapse of leukemia after allogeneic hematopoietic stem cell transplantation","volume":"14","author":"Oshima","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1182\/blood.V67.1.195.195","article-title":"The risks of central nervous system relapse and leukoencephalopathy in patients receiving marrow transplants for acute leukemia","volume":"67","author":"Thompson","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijrobp.2010.01.062","article-title":"Impact of cranial irradiation added to intrathecal conditioning in hematopoietic cell transplantation in adult acute myeloid leukemia with central nervous system involvement","volume":"80","author":"Mayadev","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1200\/JCO.1996.14.1.18","article-title":"Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia","volume":"14","author":"Smith","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib12","first-page":"324","article-title":"Fractionated total-body irradiation, etoposide, and cyclophosphamide followed by allogeneic bone marrow transplantation for patients with high-risk or advanced-stage hematological malignancies","volume":"3","author":"Long","year":"1997","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.radonc.2005.11.009","article-title":"A simple technique for craniospinal radiotherapy in the supine position","volume":"78","author":"Parker","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1053-4296(03)00031-6","article-title":"CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment","volume":"13","author":"Trotti","year":"2003","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib16","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(09)60237-3","article-title":"Graft-versus-host disease","volume":"373","author":"Ferrara","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1200\/JCO.1995.13.2.333","article-title":"An intensive re-treatment protocol for children with an isolated CNS relapse of acute lymphoblastic leukemia","volume":"13","author":"Ribeiro","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib18","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1200\/JCO.1999.17.12.3745","article-title":"Improved survival of children with isolated CNS relapse of acute lymphoblastic leukemia: A Pediatric Oncology Group study","volume":"17","author":"Ritchey","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/sj.leu.2405037","volume":"22","author":"Eapen","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0360-3016(94)00432-K","article-title":"A prospective neurocognitive evaluation of children treated with additional chemotherapy and craniospinal irradiation following isolated central nervous system relapse in acute lymphoblastic leukemia","volume":"31","author":"Kumar","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib21","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1200\/JCO.1987.5.6.933","article-title":"Intellectual and academic achievement status after CNS relapse: A retrospective analysis of 40 children treated for acute lymphoblastic leukemia","volume":"5","author":"Mulhern","year":"1987","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00043426-199021000-00008","article-title":"Treatment of meningeal relapse in childhood acute lymphoblastic leukemia: II. A prospective study of intellectual loss specific to CNS relapse and therapy","volume":"12","author":"Longeway","year":"1990","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib23","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/MPH.0b013e31820d86f2","article-title":"Long-term neurocognitive outcomes in young adult survivors of childhood acute lymphoblastic leukemia","volume":"33","author":"Edelstein","year":"2011","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/pbc.20860","article-title":"A meta-analysis of the neurocognitive sequelae of treatment for childhood acute lymphocytic leukemia","volume":"49","author":"Campbell","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib25","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1542\/peds.75.4.745","article-title":"Neuropsychological sequelae of childhood cancer in long-term survivors","volume":"75","author":"Copeland","year":"1985","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib26","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1200\/JCO.1994.12.12.2621","article-title":"Neuropsychologic effects of cranial irradiation, intrathecal methotrexate, and systemic methotrexate in childhood cancer","volume":"12","author":"Butler","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib27","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1182\/blood-2004-03-1155","article-title":"Neuropsychologic changes from before transplantation to 1 year in patients receiving myeloablative allogeneic hematopoietic cell transplant","volume":"104","author":"Syrjala","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2014.01.056_bib28","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1056\/NEJMoa0900386","article-title":"Treating childhood acute lymphoblastic leukemia without cranial irradiation","volume":"360","author":"Pui","year":"2009","journal-title":"N Engl J Med"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614001849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614001849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T20:16:15Z","timestamp":1716668175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301614001849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0360301614001849"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.01.056","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}