{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:34:25Z","timestamp":1792895665048,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","patient-research.elsevier.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.ijrobp.2014.05.003","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T12:30:19Z","timestamp":1403958619000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["microRNA Alterations Driving Acute and Late Stages of Radiation-Induced Fibrosis in a Murine Skin Model"],"prefix":"10.1016","volume":"90","author":[{"given":"Brittany A.","family":"Simone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu D.","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Ylaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Shankavaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Camphausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2014.05.003_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0140-6736(92)90219-S","article-title":"Clinical practice of radiotherapy","volume":"339","author":"Tobias","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib2","first-page":"299","article-title":"Radiotherapy and wound healing: Principles, management and prospects (review)","volume":"26","author":"Gieringer","year":"2011","journal-title":"Oncol Reps"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib3","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/PRS.0b013e3182818b94","article-title":"Skin perfusion and oxygenation changes in radiation fibrosis","volume":"131","author":"Chin","year":"2013","journal-title":"Plast Reconstr Surg"},{"issue":"Suppl 5","key":"10.1016\/j.ijrobp.2014.05.003_bib4","first-page":"S107","article-title":"Radiation fibrosis of the vocal fold: From man to mouse","volume":"122","author":"Johns","year":"2012","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/09553000410001692726","article-title":"Chronic oxidative stress and radiation-induced late normal tissue injury: A review","volume":"80","author":"Robbins","year":"2004","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib6","first-page":"37","article-title":"Radiation-induced lung injury. Assessment, management, and prevention","volume":"22","author":"Ghafoori","year":"2008","journal-title":"Oncology"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1742-481X.2007.00351.x","article-title":"Radiotherapy and wound healing","volume":"5","author":"Devalia","year":"2008","journal-title":"Int Wound J"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib8","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ijrobp.2012.06.042","article-title":"Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter","volume":"85","author":"Jacobson","year":"2013","journal-title":"Int J Radiat Oncol Biol Physics"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib9","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1200\/JCO.2003.06.064","article-title":"Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis","volume":"21","author":"Delanian","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1748-717X-2-19","article-title":"Oral pirfenidone in patients with chronic fibrosis resulting from radiotherapy: A pilot study","volume":"2","author":"Simone","year":"2007","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib11","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S1053-4296(03)00037-7","article-title":"Late radiation-related fibrosis: Pathogenesis, manifestations, and current management","volume":"13","author":"O'Sullivan","year":"2003","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib13","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1083\/jcb.129.5.1177","article-title":"The many faces of hepatocyte growth factor: From hepatopoiesis to hematopoiesis","volume":"129","author":"Zarnegar","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10555-007-9107-6","article-title":"The Met tyrosine kinase receptor in development and cancer","volume":"27","author":"Gentile","year":"2008","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib15","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1111\/j.1742-4658.2010.07632.x","article-title":"MicroRNAs and the regulation of fibrosis","volume":"277","author":"Jiang","year":"2010","journal-title":"FEBS J"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib16","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0360-3016(84)90177-9","article-title":"Leg contracture in mice: An assay of normal tissue response","volume":"10","author":"Stone","year":"1984","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib17","doi-asserted-by":"crossref","first-page":"15167","DOI":"10.1074\/jbc.M309798200","article-title":"Amelioration of radiation-induced fibrosis: Inhibition of transforming growth factor-beta signaling by halofuginone","volume":"279","author":"Xavier","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib18","first-page":"289","article-title":"Demonstration of all connective tissue elements in a single section; pentachrome stains","volume":"60","author":"Movat","year":"1955","journal-title":"AMA Arch Pathol"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib19","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib20","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1261\/rna.965408","article-title":"MiRDB: A microRNA target prediction and functional annotation database with a wiki interface","volume":"14","author":"Wang","year":"2008","journal-title":"RNA"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/bioinformatics\/btm595","article-title":"Prediction of both conserved and nonconserved microRNA targets in animals","volume":"24","author":"Wang","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta c(t)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib23","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.pmrj.2011.08.535","article-title":"Radiation fibrosis syndrome: Neuromuscular and musculoskeletal complications in cancer survivors","volume":"3","author":"Stubblefield","year":"2011","journal-title":"PM R"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1748-717X-3-40","article-title":"Radiation-induced skin injury in the animal model of scleroderma: Implications for post-radiotherapy fibrosis","volume":"3","author":"Kumar","year":"2008","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib25","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.ijrobp.2006.01.031","article-title":"Protective effect of esculentoside a on radiation-induced dermatitis and fibrosis","volume":"65","author":"Xiao","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib26","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1053\/j.gastro.2009.01.068","article-title":"C-met confers protection against chronic liver tissue damage and fibrosis progression after bile\u00a0duct ligation in mice","volume":"137","author":"Giebeler","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib27","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3892\/or.2013.2351","article-title":"Downregulation of microRNA-34 induces cell proliferation and invasion of human mesothelial cells","volume":"29","author":"Tanaka","year":"2013","journal-title":"Oncol Rep"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.canlet.2008.09.035","article-title":"Mir-34a inhibits migration and invasion by down-regulation of c-met expression in human hepatocellular carcinoma cells","volume":"275","author":"Li","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S1607-551X(09)70560-1","article-title":"Hepatocyte growth factor suppresses transforming growth factor-beta-1 and type III collagen in human primary renal fibroblasts","volume":"25","author":"Mou","year":"2009","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib30","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.bbadis.2012.02.012","article-title":"Loss of c-met accelerates development of liver fibrosis in response to ccl(4) exposure through deregulation of multiple molecular pathways","volume":"1822","author":"Marquardt","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib31","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1053\/j.gastro.2008.01.014","article-title":"Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of smad3 with galectin-7","volume":"134","author":"Inagaki","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib32","doi-asserted-by":"crossref","first-page":"e24568","DOI":"10.1371\/journal.pone.0024568","article-title":"Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction","volume":"6","author":"Kwiecinski","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib33","doi-asserted-by":"crossref","first-page":"e50924","DOI":"10.1371\/journal.pone.0050924","article-title":"Hepatocyte growth factor increases vascular endothelial growth factor-a production in human synovial fibroblasts through c-met receptor pathway","volume":"7","author":"Lin","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib34","first-page":"343","article-title":"Hepatocyte growth factor gene-modified mesenchymal stem cells reduce radiation-induced lung injury","volume":"24","author":"Wang","year":"2013","journal-title":"HumGene Ther"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/1471-2407-11-139","article-title":"Transcriptional activation of the Axl and PDGFR-alpha by c-Met through a ras- and Src-independent mechanism in human bladder cancer","volume":"11","author":"Yeh","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib36","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1074\/jbc.271.8.4251","article-title":"An 11-amino acid sequence from c-met initiates epithelial chemotaxis via phosphatidylinositol 3-kinase and phospholipase c","volume":"271","author":"Derman","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib37","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ctrv.2005.07.007","article-title":"The role of pentoxifylline as a modifier of radiation therapy","volume":"31","author":"Nieder","year":"2005","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib38","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0360-3016(98)00419-2","article-title":"Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: An experimental study","volume":"43","author":"Lefaix","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.05.003_bib39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.7150\/ijbs.7.221","article-title":"Mir-34a in age and tissue related radio-sensitivity and serum mir-34a as a novel indicator of radiation injury","volume":"7","author":"Liu","year":"2011","journal-title":"Int J Biol Sci"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614005872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614005872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:49:46Z","timestamp":1565570986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301614005872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0360301614005872"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.05.003","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"microRNA Alterations Driving Acute and Late Stages of Radiation-Induced Fibrosis in a Murine Skin Model","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}