{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:05:34Z","timestamp":1784649934937,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.ijrobp.2014.06.061","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T13:29:37Z","timestamp":1409750977000},"page":"587-594","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Prospective Evaluation of Acute Toxicity and Quality of Life After IMRT and Concurrent Chemotherapy for Anal Canal and Perianal Cancer"],"prefix":"10.1016","volume":"90","author":[{"given":"Kathy","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Lindsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Skliarenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa W.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Brierley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dinniwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Bayley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolie","family":"Ringash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika K.","family":"Krzyzanowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm J.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric X.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Easson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Kassam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2014.06.061_bib1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/BF02586980","article-title":"Combined therapy for cancer of the anal canal: A preliminary report","volume":"17","author":"Nigro","year":"1974","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/0360-3016(91)90265-6","article-title":"Epidermoid anal cancer: Treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C","volume":"21","author":"Cummings","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib3","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1200\/JCO.1996.14.9.2527","article-title":"Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: Results of a phase III randomized intergroup study","volume":"14","author":"Flam","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib4","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1001\/jama.299.16.1914","article-title":"Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: A randomized controlled trial","volume":"299","author":"Ajani","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/sj.bjc.6605605","article-title":"Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomised UKCCCR Anal Cancer Trial (ACT I)","volume":"102","author":"Northover","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib6","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1200\/JCO.2007.12.0170","article-title":"Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: A multicenter experience","volume":"25","author":"Salama","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib7","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1002\/cncr.25901","article-title":"Intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal","volume":"117","author":"Bazan","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijrobp.2010.09.030","article-title":"Dose-painted intensity-modulated radiation therapy for anal cancer: A multi-institutional report of acute toxicity and response to therapy","volume":"82","author":"Kachnic","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib9","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.ijrobp.2009.09.046","article-title":"Intensity-modulated radiation therapy for anal malignancies: A preliminary toxicity and disease outcomes analysis","volume":"78","author":"Pepek","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib10","article-title":"Intensity-modulated radiation therapy with concurrent chemotherapy for anal cancer: Outcomes and toxicity","author":"Mitchell","year":"2013","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijrobp.2012.09.023","article-title":"RTOG 0529: A phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal","volume":"86","author":"Kachnic","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib12","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.clon.2004.05.007","article-title":"Quality of life after non-surgical treatment of anal carcinoma: A case control study of long-term survivors","volume":"16","author":"Jephcott","year":"2004","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib13","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/cncr.24906","article-title":"Long-term quality of life after radiotherapy for the treatment of anal cancer","volume":"116","author":"Das","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib14","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3109\/0284186X.2013.770599","article-title":"Impaired health-related quality of life after chemoradiotherapy for anal cancer: Late effects in a national cohort of 128 survivors","volume":"52","author":"Bentzen","year":"2013","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib15","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00066-013-0314-5","article-title":"Chronic adverse events and quality of life after radiochemotherapy in anal cancer patients: A single institution experience and review of the literature","volume":"189","author":"Fakhrian","year":"2013","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00066-010-2175-5","article-title":"Quality of life outcomes in patients with anal cancer after combined radiochemotherapy","volume":"187","author":"Welzel","year":"2011","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib17","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1038\/sj.bjc.6690567","article-title":"Assessment of long-term quality of life in patients with anal carcinomas treated by radiotherapy with or without chemotherapy","volume":"80","author":"Allal","year":"1999","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1748-717X-5-41","article-title":"Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma","volume":"5","author":"Provencher","year":"2010","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.radonc.2007.12.004","article-title":"Radiochemotherapy of locally advanced anal canal carcinoma: Prospective assessment of early impact on the quality of life (randomized trial ACCORD 03)","volume":"87","author":"Tournier-Rangeard","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib20","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ijrobp.2008.09.026","article-title":"Pelvic lymph node topography for radiotherapy treatment planning from ferumoxtran-10 contrast-enhanced magnetic resonance imaging","volume":"74","author":"Dinniwell","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib21","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.ijrobp.2008.08.070","article-title":"Elective clinical target volumes for conformal therapy in anorectal cancer: A radiation therapy oncology group consensus panel contouring atlas","volume":"74","author":"Myerson","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib23","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1016\/j.ejca.2009.08.014","article-title":"Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer","volume":"45","author":"Whistance","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1200\/JCO.1998.16.1.139","article-title":"Interpreting the significance of changes in health-related quality-of-life scores","volume":"16","author":"Osoba","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib25","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1016\/j.ijrobp.2012.01.023","article-title":"Pelvic normal tissue contouring guidelines for radiation therapy: A Radiation Therapy Oncology Group consensus panel atlas","volume":"83","author":"Gay","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib26","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.ijrobp.2007.08.074","article-title":"Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy","volume":"70","author":"Mell","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF02294164","article-title":"The polyserial correlation coefficient","volume":"47","author":"Olsson","year":"1982","journal-title":"Psychometrika"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib28","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ijrobp.2011.12.072","article-title":"Normal tissue complication probability modeling of acute hematologic toxicity in patients treated with intensity-modulated radiation therapy for squamous cell carcinoma of the anal canal","volume":"84","author":"Bazan","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib29","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/jjco\/hyl002","article-title":"Health-related quality of life after intensity modulated radiation therapy for localized prostate cancer: Comparison with conventional and conformal radiotherapy","volume":"36","author":"Namiki","year":"2006","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.radonc.2009.07.006","article-title":"A multi-institutional acute gastrointestinal toxicity analysis of anal cancer patients treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy","volume":"93","author":"Devisetty","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000348387","article-title":"Dosimetric parameters predictive of acute gastrointestinal toxicity in patients with anal carcinoma treated with concurrent chemotherapy and intensity-modulated radiation therapy","volume":"85","author":"DeFoe","year":"2013","journal-title":"Oncology"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib32","first-page":"129","article-title":"Predictors of acute gastrointestinal toxicity during pelvic chemoradiotherapy in patients with rectal cancer","volume":"6","author":"Yang","year":"2013","journal-title":"Gastrointest Cancer Res"},{"key":"10.1016\/j.ijrobp.2014.06.061_bib33","first-page":"119","article-title":"Patient-reported outcomes vs. clinician symptom reporting during chemoradiation for rectal cancer","volume":"5","author":"Flores","year":"2012","journal-title":"Gastrointest Cancer Res"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614034361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614034361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T12:51:41Z","timestamp":1565787101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301614034361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0360301614034361"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.06.061","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prospective Evaluation of Acute Toxicity and Quality of Life After IMRT and Concurrent Chemotherapy for Anal Canal and Perianal Cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.06.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}