{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:44:17Z","timestamp":1788234257704,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.ijrobp.2014.07.003","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T17:09:01Z","timestamp":1409764141000},"page":"637-644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Intensity Modulated Proton Therapy for Craniospinal Irradiation: Organ-at-Risk Exposure and a Low-Gradient Junctioning Technique"],"prefix":"10.1016","volume":"90","author":[{"given":"Joshua B.","family":"Stoker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Ronald","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Pidikiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-4451","authenticated-orcid":false,"given":"Anita","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Grosshans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2014.07.003_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1634\/theoncologist.4-1-45","article-title":"Long-term survivors of childhood cancer: The late effects of therapy","volume":"4","author":"Schwartz","year":"1999","journal-title":"Oncologist"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/neuonc\/not155","article-title":"Technique, outcomes, and acute toxicities in adults treated with proton beam craniospinal irradiation","volume":"16","author":"Barney","year":"2014","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib3","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.ijrobp.2007.08.027","article-title":"Radiation dose to the lens during craniospinal irradiation-an improvement in proton radiotherapy technique","volume":"70","author":"Cochran","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1748-717X-7-116","article-title":"Comparison of therapeutic dosimetric data from passively scattered proton and photon craniospinal irradiations for medulloblastoma","volume":"7","author":"Howell","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0360-3016(03)01574-8","article-title":"Advantage of protons compared to conventional X-ray or IMRT in the treatment of a pediatric patient with medulloblastoma","volume":"58","author":"St Clair","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijrobp.2013.01.014","article-title":"Proton Beam Craniospinal Irradiation Reduces Acute Toxicity for Adults With Medulloblastoma","volume":"86","author":"Brown","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1748-717X-6-58","article-title":"Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy","volume":"6","author":"Moeller","year":"2011","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.radonc.2014.01.016","article-title":"Non-invasive anesthesia for children undergoing proton radiation therapy","volume":"111","author":"Owusu-Agyemang","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1748-717X-8-32","article-title":"Standardized treatment planning methodology for passively scattered proton craniospinal irradiation","volume":"8","author":"Giebeler","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/1748-717X-8-289","article-title":"Comparison of proton therapy techniques for treatment of the whole brain as a component of craniospinal irradiation","volume":"8","author":"Dinh","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib11","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1118\/1.3679340","article-title":"Robust optimization of intensity modulated proton therapy","volume":"39","author":"Liu","year":"2012","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib12","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1088\/0031-9155\/47\/13\/303","article-title":"The value of radiographic film for the characterization of intensity-modulated beams","volume":"47","author":"Martens","year":"2002","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1120\/1.1508013","article-title":"Method to plan, administer, and verify\u00a0supine craniospinal irradiation","volume":"3","author":"Michalski","year":"2002","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib14","series-title":"Stata: release 13","author":"StataCorp","year":"2013"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib15","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.ijrobp.2007.02.037","article-title":"Craniospinal irradiation with spinal IMRT to improve target homogeneity","volume":"68","author":"Pai Panandiker","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib16","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.ijrobp.2007.04.062","article-title":"Field-in-field technique with intrafractionally modulated junction shifts for craniospinal irradiation","volume":"69","author":"Yom","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib17","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0360-3016(93)90310-R","article-title":"Radiation dose to the lens and cataract formation","volume":"25","author":"Henk","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2307\/3580093","article-title":"Lenticular opacities in individuals exposed to ionizing radiation in infancy","volume":"152","author":"Hall","year":"1999","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib19","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.ijrobp.2009.04.096","article-title":"Radiation therapy and hearing loss","volume":"76","author":"Bhandare","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib20","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.ijrobp.2009.06.090","article-title":"Radiotherapy dose-volume effects on salivary gland function","volume":"76","author":"Deasy","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib21","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/1748-717X-7-174","article-title":"The clinical case for proton beam therapy","volume":"7","author":"Foote","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib22","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1088\/0031-9155\/54\/8\/002","article-title":"The risk of developing a second cancer after receiving craniospinal proton irradiation","volume":"54","author":"Newhauser","year":"2009","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib23","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1016\/j.ijrobp.2011.05.005","article-title":"Using a reduced spot size for intensity-modulated proton therapy potentially improves salivary gland-sparing in oropharyngeal cancer","volume":"82","author":"van de Water","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib24","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1118\/1.1485059","article-title":"Multiple local minima in IMRT optimization based on dose-volume criteria","volume":"29","author":"Wu","year":"2002","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2014.07.003_bib25","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.ijrobp.2008.01.050","article-title":"Hearing loss after radiotherapy for pediatric brain tumors: Effect of cochlear dose","volume":"72","author":"Hua","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614034701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614034701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T01:32:32Z","timestamp":1598232752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301614034701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0360301614034701"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.07.003","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intensity Modulated Proton Therapy for Craniospinal Irradiation: Organ-at-Risk Exposure and a Low-Gradient Junctioning Technique","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}