{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:54:55Z","timestamp":1789865695304,"version":"4.0.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.ijrobp.2014.08.008","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T10:28:13Z","timestamp":1412850493000},"page":"1168-1176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["Local Control and Toxicity in a Large Cohort of Central Lung Tumors Treated With Stereotactic Body Radiation Therapy"],"prefix":"10.1016","volume":"90","author":[{"given":"Ankit","family":"Modh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rimner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1738-4982","authenticated-orcid":false,"given":"Eric","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiji","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphna Y.","family":"Gelblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E.","family":"Rosenzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen D.","family":"Yorke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-7091","authenticated-orcid":false,"given":"Abraham J.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2014.08.008_bib1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ijrobp.2008.11.042","article-title":"Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: Four-year results of a prospective phase II study","volume":"75","author":"Fakiris","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib2","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1001\/jama.2010.261","article-title":"Stereotactic body radiation therapy for inoperable early stage lung cancer","volume":"303","author":"Timmerman","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib3","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1200\/JCO.2006.07.5937","article-title":"Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer","volume":"24","author":"Timmerman","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib4","unstructured":"Bezjak A. Stereotactic body radiation therapy in treating patients with stage I non-small cell lung cancer. Available at: http:\/\/clinicaltrials.gov\/show\/NCT00750269. Last accessed August 4, 2014."},{"key":"10.1016\/j.ijrobp.2014.08.008_bib5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0360-3016(98)90033-5","article-title":"A comprehensive three-dimensional radiation treatment planning system","volume":"15","author":"Mohan","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib6","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1118\/1.597206","article-title":"Dose calculation for photon beams with intensity modulation generated by dynamic jaw or multileaf collimations","volume":"21","author":"Chui","year":"1994","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib7","doi-asserted-by":"crossref","first-page":"645","DOI":"10.6004\/jnccn.2013.0084","article-title":"Non-small cell lung cancer, version 2.2013","volume":"11","author":"Ettinger","year":"2013","journal-title":"J Natl Compr Cancer Netw"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0167-8140(97)00162-X","article-title":"The linear-quadratic transformation of dose-volume histograms in fractionated radiotherapy","volume":"46","author":"Wheldon","year":"1998","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib9","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2307\/2529885","article-title":"The use of mixture models for the analysis of survival data with long-term survivors","volume":"38","author":"Farewell","year":"1982","journal-title":"Biometrics"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib10","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/0360-3016(86)90331-7","article-title":"Effect of latency on calculated complication rates","volume":"12","author":"Schultheiss","year":"1986","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib11","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.ijrobp.2010.01.069","article-title":"Late rectal toxicity on RTOG 94-06: Analysis using a mixture Lyman model","volume":"78","author":"Tucker","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib12","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1016\/j.ijrobp.2009.06.094","article-title":"Improving normal tissue complication probability models: The need to adopt a \u201cdata-pooling\u201d culture","volume":"76","author":"Deasy","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib13","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1016\/j.ijrobp.2009.08.074","article-title":"The lessons of QUANTEC: Recommendations for reporting and gathering data on dose-volume dependencies of treatment outcome","volume":"76","author":"Jackson","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib14","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.semradonc.2006.04.009","article-title":"The atlas of complication incidence: A proposal for a new standard for reporting the results of radiotherapy protocols","volume":"16","author":"Jackson","year":"2006","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib15","doi-asserted-by":"crossref","first-page":"e661","DOI":"10.1016\/j.ijrobp.2012.01.080","article-title":"Esophageal toxicity from high-dose, single-fraction paraspinal stereotactic radiosurgery","volume":"83","author":"Cox","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00066-010-2072-y","article-title":"Stereotactic body radiotherapy for lung tumors at the pulmonary hilum","volume":"186","author":"Oshiro","year":"2010","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib17","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.ijrobp.2010.04.056","article-title":"Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a phase II trial","volume":"80","author":"Bral","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib18","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/cncr.20539","article-title":"Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: Clinical outcomes in 245 subjects in a Japanese multiinstitutional study","volume":"101","author":"Onishi","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib19","doi-asserted-by":"crossref","first-page":"e379","DOI":"10.1016\/j.ijrobp.2012.04.040","article-title":"Modeling local control after hypofractionated stereotactic body radiation therapy for stage I non-small cell lung cancer: A report from the Elekta collaborative lung research group","volume":"84","author":"Ohri","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib20","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1097\/JTO.0b013e3182614bf3","article-title":"Stereotactic body radiotherapy for central lung tumors","volume":"7","author":"Rowe","year":"2012","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.radonc.2013.01.004","article-title":"Outcomes of stereotactic ablative radiotherapy for central lung tumours: A systematic review","volume":"106","author":"Senthi","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib22","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1097\/JTO.0b013e31822e71d8","article-title":"Outcomes of stereotactic ablative radiotherapy for centrally located early-stage lung cancer","volume":"6","author":"Haasbeek","year":"2011","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib23","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ijrobp.2008.08.001","article-title":"Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer","volume":"72","author":"Chang","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.athoracsur.2011.09.079","article-title":"Local extension at the hilum region is associated with worse long-term survival in stage I non-small cell lung cancers","volume":"93","author":"Chen","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib25","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.ijrobp.2014.01.022","article-title":"Stereotactic ablative radiation therapy for centrally located early stage or isolated parenchymal recurrences of non-small cell lung cancer: How to fly in a \u201cno fly zone\u201d","volume":"88","author":"Chang","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.008_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ijrobp.2010.08.056","article-title":"A dose-volume analysis of radiation pneumonitis in non-small cell lung cancer patients treated with stereotactic body radiation therapy","volume":"82","author":"Barriger","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614036578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614036578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T13:57:50Z","timestamp":1538143070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301614036578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0360301614036578"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.08.008","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local Control and Toxicity in a Large Cohort of Central Lung Tumors Treated With Stereotactic Body Radiation Therapy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}