{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:09:56Z","timestamp":1779332996112,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["C06 CA059267"],"award-info":[{"award-number":["C06 CA059267"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["RTOG U10 CA 021661"],"award-info":[{"award-number":["RTOG U10 CA 021661"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01CA021239-32"],"award-info":[{"award-number":["P01CA021239-32"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","award":["C06 CA059267"],"award-info":[{"award-number":["C06 CA059267"]}],"id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.ijrobp.2014.08.016","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T21:46:15Z","timestamp":1417038375000},"page":"1030-1036","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["[18F]-Fluoromisonidazole Positron Emission Tomography\/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine"],"prefix":"10.1016","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-3427","authenticated-orcid":false,"given":"Matthew D.","family":"Cheney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara K.","family":"Winrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca L.","family":"Grosu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei V.","family":"Trofimov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Depauw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen A.","family":"Shih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph H.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis J.","family":"Hornicek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"DeLaney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2014.08.016_bib1","first-page":"417","article-title":"Chordoma: A critical review of diagnosis and treatment","volume":"20","author":"Healey","year":"1989","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib2","first-page":"1","article-title":"Chordoma: Incidence and survival patterns in the United States, 1973-1995","volume":"12","author":"McMaster","year":"2001","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/path.1711710404","article-title":"The pathology of the human notochord","volume":"171","author":"Salisbury","year":"1993","journal-title":"J Pathol"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib4","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/01.brs.0000200038.30869.27","article-title":"Chordoma of the mobile spine: Fifty years of experience","volume":"31","author":"Boriani","year":"2006","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib5","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1097\/00007632-199908150-00004","article-title":"Lumbosacral chordoma. Prognostic factors and treatment","volume":"24","author":"Cheng","year":"1999","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib6","doi-asserted-by":"crossref","first-page":"688","DOI":"10.6004\/jnccn.2013.0088","article-title":"Bone cancer","volume":"11","author":"Biermann","year":"2013","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib7","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1007\/s11999-010-1472-8","article-title":"Surgical margins and local control in resection of sacral chordomas","volume":"468","author":"Ruggieri","year":"2010","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib8","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.2106\/00004623-199310000-00008","article-title":"Operative treatment of sacrococcygeal chordoma. A review of twenty-one cases","volume":"75","author":"Samson","year":"1993","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib9","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1097\/BRS.0b013e3181bad11d","article-title":"The surgical management of sacral chordomas","volume":"34","author":"Schwab","year":"2009","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib10","first-page":"3148s","article-title":"Internal radionuclide therapy of primary osteosarcoma in dogs, using 153Sm-ethylene-diamino-tetramethylene-phosphonate (EDTMP)","volume":"5","author":"Aas","year":"1999","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1245\/ASO.2003.06.002","article-title":"Chordoma: Natural history and results in 28 patients treated at a single institution","volume":"10","author":"Baratti","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib12","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1002\/(SICI)1097-0142(20000501)88:9<2122::AID-CNCR19>3.0.CO;2-1","article-title":"Prognostic factors in chordoma of the sacrum and mobile spine: A study of 39 patients","volume":"88","author":"Bergh","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib13","first-page":"2211","article-title":"Operative management of sacral chordoma","volume":"87","author":"Fuchs","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib14","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1007\/s11999-008-0356-7","article-title":"Sacral chordoma: Can local recurrence after sacrectomy be predicted?","volume":"466","author":"Hanna","year":"2008","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib15","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.2106\/JBJS.D.02533","article-title":"Oncologic and functional outcome following sacrectomy for sacral chordoma","volume":"88","author":"Hulen","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/(SICI)1096-9098(199704)64:4<274::AID-JSO5>3.0.CO;2-6","article-title":"Surgical treatment of sacrococcygeal chordoma","volume":"64","author":"Ozaki","year":"1997","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib17","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/(SICI)1097-0142(19990215)85:4<878::AID-CNCR15>3.0.CO;2-7","article-title":"The surgical management of sacrococcygeal chordoma","volume":"85","author":"Yonemoto","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00006123-199901000-00041","article-title":"Sacral chordoma: 40-year experience at a major cancer center","volume":"44","author":"York","year":"1999","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib19","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ijrobp.2008.08.058","article-title":"Phase II study of high-dose photon\/proton radiotherapy in the management of spine sarcomas","volume":"74","author":"DeLaney","year":"2009","journal-title":"Int J\u00a0Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib20","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.ijrobp.2006.02.059","article-title":"Sacral chordomas: Impact of high-dose proton\/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor","volume":"65","author":"Park","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0360-3016(98)90012-8","article-title":"Radiotherapy for chordoma","volume":"15","author":"Fuller","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib22","doi-asserted-by":"crossref","first-page":"E930","DOI":"10.1097\/BRS.0b013e318296e7d7","article-title":"Definitive high-dose photon\/proton radiotherapy for unresected mobile spine and sacral chordomas","volume":"38","author":"Chen","year":"2013","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib23","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.ijrobp.2009.06.048","article-title":"Effect of carbon ion radiotherapy for sacral chordoma: Results of phase I-II and phase II clinical trials","volume":"77","author":"Imai","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nrc2344","article-title":"Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability","volume":"8","author":"Bristow","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib25","first-page":"4509","article-title":"Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix","volume":"56","author":"Hockel","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib26","first-page":"253","article-title":"Prognostic impact of hypoxia imaging with 18f-misonidazole pet in non-small cell lung cancer and head and neck cancer before radiotherapy","volume":"46","author":"Eschmann","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0360-3016(95)00170-4","article-title":"Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography","volume":"33","author":"Koh","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ijrobp.2007.06.039","article-title":"Fluorine-18-labeled fluoromisonidazole positron emission and computed tomography-guided intensity-modulated radiotherapy for head and neck cancer: A feasibility study","volume":"70","author":"Lee","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib29","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.ijrobp.2011.12.047","article-title":"Positron emission tomography\/computed tomography imaging of residual skull base chordoma before radiotherapy using fluoromisonidazole and fluorodeoxyglucose: Potential consequences for dose painting","volume":"84","author":"Mammar","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib30","series-title":"Inference for Contingency Tables, Categorical Data Analysis","author":"Agresti","year":"2002"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib31","series-title":"Nonparametric Statistical Methods","author":"Hollander","year":"1999"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib32","unstructured":"R Core Team. R: A language and environment for statistical computing. Available at: http:\/\/www.R-project.org\/. Accessed February 3,\u00a02014."},{"key":"10.1016\/j.ijrobp.2014.08.016_bib33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ijrobp.2005.04.019","article-title":"Cauda equina tolerance to high-dose fractionated irradiation","volume":"64","author":"Pieters","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib34","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.ijrobp.2007.09.050","article-title":"The influence of changes in tumor hypoxia on dose-painting treatment plans based on 18F-FMISO positron emission tomography","volume":"70","author":"Lin","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijrobp.2007.08.036","article-title":"Reproducibility of intratumor distribution of (18)F-fluoromisonidazole in head and neck cancer","volume":"70","author":"Nehmeh","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.016_bib36","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.ijrobp.2009.07.009","article-title":"Noninvasive assessment of tumor\u00a0microenvironment using dynamic contrast-enhanced magnetic resonance imaging and 18F-fluoromisonidazole positron emission tomography imaging in neck nodal metastases","volume":"77","author":"Jansen","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614036980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614036980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:05:55Z","timestamp":1778537155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301614036980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0360301614036980"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.08.016","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"[18F]-Fluoromisonidazole Positron Emission Tomography\/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}