{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:43:19Z","timestamp":1768790599801,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.ijrobp.2014.08.347","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T13:35:17Z","timestamp":1413207317000},"page":"1250-1257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Modelling the Impact of Fractionation on Late Urinary Toxicity After Postprostatectomy Radiation Therapy"],"prefix":"10.1016","volume":"90","author":[{"given":"Claudio","family":"Fiorino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Cozzarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Rancati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Mauro","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Mangili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia Gisella","family":"Di Muzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Calandrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2014.08.347_bib1","series-title":"Basic Clinical Radiobiology","first-page":"169","article-title":"Pathogenesis of normal tissue side-effects","author":"Dorr","year":"2009"},{"issue":"Suppl. 3","key":"10.1016\/j.ijrobp.2014.08.347_bib2","first-page":"S123","article-title":"Radiation dose volume effects of the urinary bladder","volume":"76","author":"Viswanathan","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.radonc.2009.08.004","article-title":"Dose-volume effects for normal tissues in external radiotherapy: Pelvis","volume":"93","author":"Fiorino","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib4","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0360-3016(94)00431-J","article-title":"The response of the urinary bladder, urethra and ureter to radiation and chemotherapy","volume":"31","author":"Marks","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.eururo.2011.09.027","article-title":"Functional outcome and complications following radiation therapy for prostate cancer: A critical analysis of the literature","volume":"61","author":"Budaus","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijrobp.2010.09.027","article-title":"Clinical factors predicting late severe urinary toxicity after postoperative radiotherapy for prostate carcinoma: A single-institute analysis of 742 patients","volume":"82","author":"Cozzarini","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0360-3016(02)04117-2","article-title":"Significant correlation between rectal DVH and late bleeding in patients treated after radical prostatectomy with conformal or conventional radiotherapy (66.6-70.2 Gy)","volume":"55","author":"Cozzarini","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.radonc.2008.03.021","article-title":"Hypofractionated adjuvant radiotherapy with helical Tomotherapy after radical prostatectomy: Planning data and toxicity results of a Phase I-II study","volume":"88","author":"Cozzarini","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.radonc.2007.07.013","article-title":"Significant reduction of acute toxicity following pelvic irradiation with helical tomotherapy in patients with localized prostate cancer","volume":"84","author":"Cozzarini","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.radonc.2009.08.042","article-title":"IMRT significantly reduces acute toxicity of whole-pelvis irradiation in patients treated with post-operative adjuvant or salvage radiotherapy after radical prostatectomy","volume":"93","author":"Alongi","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib11","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1002\/cncr.25824","article-title":"Early hypofractionated salvage radiotherapy for postprostatectomy biochemical recurrence","volume":"117","author":"Kruser","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib12","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1186\/1471-2407-12-504","article-title":"Hypofractionated helical intensity-modulated radiotherapy of the prostate bed after prostatectomy with or without the pelvic lymph nodes\u2014the PRIAMOS trial","volume":"12","author":"Krause","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib13","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.clon.2004.07.006","article-title":"Hypofractionated radiotherapy as salvage for rising prostate-specific antigen after radical prostatectomy","volume":"16","author":"Lee","year":"2004","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib14","unstructured":"Cozzarini C, Fiorino C, Deantoni C et al. Higher than expected severe (grade 3-4) late urinary toxicity after post-prostatectomy hypofractionated radiotherapy: A single institution analysis of 1176 patients. Eur Urol (In press)."},{"key":"10.1016\/j.ijrobp.2014.08.347_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/02841860410002824","article-title":"The radiobiology of prostate cancer including new aspects of fractionated radiotherapy","volume":"44","author":"Fowler","year":"2005","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.radonc.2006.07.015","article-title":"Radiation-induced damage to mouse urothelial barrier","volume":"80","author":"Jaal","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib17","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/095530099139476","article-title":"Late functional response of mouse urinary bladder to fractionated X-irradiation","volume":"75","author":"Dorr","year":"1999","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0167-8140(01)00429-7","article-title":"Consequential late effects in normal tissues","volume":"61","author":"Dorr","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radonc.2004.08.013","article-title":"Fitting late rectal bleeding data using different NTCP models: Results from an Italian multi-centric study (AIROPROS0101)","volume":"73","author":"Rancati","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0167-8140(90)90149-Q","article-title":"Time-dose factors in radiotherapy: A review of the human data","volume":"19","author":"Thames","year":"1990","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijrobp.2009.07.1680","article-title":"Urinary obstruction in prostate cancer patients from the Dutch trial (68Gy vs 78Gy): Relationship with local dose, acute effects and baseline characteristics","volume":"78","author":"Heemsbergen","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib22","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ijrobp.2010.07.1994","article-title":"A method for the prediction of late organ-at-risk toxicity after radiotherapy of the prostate using equivalent uniform dose","volume":"80","author":"Fleming","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ijrobp.2013.10.042","article-title":"Impact of dose to the bladder trigone on long-term urinary function after high-dose intensity modulated radiation therapy for localized prostate cancer","volume":"88","author":"Ghadjar","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib24","series-title":"User Guide for NPSOL (Version 4.0): A FORTRAN Package for Nonlinear Programming","first-page":"86","author":"Gill","year":"1986"},{"issue":"Suppl. 7","key":"10.1016\/j.ijrobp.2014.08.347_bib25","first-page":"280","article-title":"Mechanism of bladder damage and repair after treatment with radiation and cytostatic drugs","author":"Stewart","year":"1986","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib26","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0167-8140(92)90251-O","article-title":"Fractionation sensitivity and late radiation injury to the mouse urinary bladder","volume":"25","author":"Bentzen","year":"1992","journal-title":"Radiother Oncol"},{"issue":"Suppl. 3","key":"10.1016\/j.ijrobp.2014.08.347_bib27","first-page":"93","article-title":"Pathogenesis of acute radiation effects in the urinary bladder. Experimental results","volume":"174","author":"Dorr","year":"1998","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib28","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1016\/j.juro.2006.07.138","article-title":"Radiation induced late damage to the barrier function of small blood vessels in mouse bladder","volume":"176","author":"Jaal","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.semradonc.2013.01.005","article-title":"Hypofractionation for localized prostate cancer","volume":"23","author":"Cabrera","year":"2013","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib30","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1200\/JCO.2013.51.1972","article-title":"Randomized trial of hypofractionated external-beam radiotherapy for prostate cancer","volume":"31","author":"Pollack","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib31","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.ijrobp.2012.02.049","article-title":"Updated results and patterns of failure in a randomized hypofractionation trial for high-risk prostate cancer","volume":"84","author":"Arcangeli","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib32","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.ijrobp.2014.01.015","article-title":"Risk of late toxicity in men receiving dose-escalated hypofractionated intensity modulated prostate radiation therapy: Results from a randomized trial","volume":"88","author":"Hoffmann","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib33","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.ijrobp.2007.01.067","article-title":"Hypofractionated intensity-modulated radiotherapy (70Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland clinical experience","volume":"68","author":"Kupelian","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.radonc.2008.11.013","article-title":"Urethral stricture following high dose rate brachytherapy for prostate cancer","volume":"91","author":"Sullivan","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.08.347_bib35","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.radonc.2014.02.006","article-title":"Relationships between bladder dose-volume\/surface histograms parameters and acute urinary toxicity after radiotherapy for prostate cancer","volume":"111","author":"Carillo","year":"2014","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614040541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614040541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T15:53:59Z","timestamp":1538150039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301614040541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0360301614040541"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.08.347","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modelling the Impact of Fractionation on Late Urinary Toxicity After Postprostatectomy Radiation Therapy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.08.347","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}