{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:53:30Z","timestamp":1792173210661,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.ijrobp.2014.12.025","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T01:30:17Z","timestamp":1425259817000},"page":"796-806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Pudendal Nerve and Internal Pudendal Artery Damage May Contribute to Radiation-Induced Erectile Dysfunction"],"prefix":"10.1016","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4432-9700","authenticated-orcid":false,"given":"Michael W.","family":"Nolan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela J.","family":"Marolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.J.","family":"Ehrhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Golden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd H.","family":"Wasserman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"LaRue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2014.12.025_bib1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.eururo.2006.06.009","article-title":"Sexual function before and after radical retropubic prostatectomy: A systematic review of prognostic indicators for a successful outcome","volume":"50","author":"Dubbelman","year":"2006","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib2","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0022-5347(17)53012-8","article-title":"Impotence following radical prostatectomy: Insight into etiology and prevention","volume":"128","author":"Walsh","year":"1982","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib3","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ijrobp.2009.07.1748","article-title":"Sexual function after stereotactic body radiotherapy for prostate cancer: Results of a prospective clinical trial","volume":"78","author":"Wiegner","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/sj.pcan.4500938","article-title":"An analysis of erectile function after intensity modulated radiation therapy for localized prostate carcinoma","volume":"10","author":"Brown","year":"2007","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.radonc.2007.07.018","article-title":"Erectile dysfunction after radiotherapy for prostate cancer and radiation dose to the penile structures: A critical review","volume":"84","author":"van der Wielen","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ucl.2005.08.007","article-title":"Physiology of penile erection and pathophysiology of erectile dysfunction","volume":"32","author":"Dean","year":"2005","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.critrevonc.2005.06.006","article-title":"Sexual function after external-beam radiotherapy for prostate cancer: What do we know?","volume":"57","author":"Incrocci","year":"2006","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0360-3016(01)02727-4","article-title":"Sexual (dys)function after radiotherapy for prostate cancer: A review","volume":"52","author":"Incrocci","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/COC.0b013e318173a563","article-title":"Erectile dysfunction after radiotherapy for prostate cancer","volume":"32","author":"Mendenhall","year":"2009","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib10","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1001\/jama.1984.03340310017012","article-title":"Radiation-associated impotence: A clinical study of its mechanism","volume":"251","author":"Goldstein","year":"1984","journal-title":"JAMA"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib11","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.ijrobp.2008.06.1946","article-title":"There is no correlation between erectile dysfunction and dose to penile bulb and neurovascular bundle following real-time low dose rate prostate brachytherapy","volume":"73","author":"Solan","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib12","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0360-3016(00)00746-X","article-title":"A comparison of radiation dose to the neurovascular bundles in men with and without prostate brachytherapy-induced erectile dysfunction","volume":"48","author":"Merrick","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib13","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0360-3016(01)01475-4","article-title":"A comparison of radiation dose to the bulb of the penis in men with and without prostate brachytherapy-induced erectile dysfunction","volume":"50","author":"Merrick","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ijrobp.2007.10.052","article-title":"Dose-volume parameters of the corpora cavernosa do not correlate with erectile dysfunction after external beam radiotherapy for prostate cancer: Results from a dose-escalation trial","volume":"71","author":"van der Wielen","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1148\/radiology.195.1.7534430","article-title":"Radiation-induced decrease in nitric oxide synthase containing nerves in the rat penis","volume":"195","author":"Carrier","year":"1995","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/sj.ijir.3900652","article-title":"New insights into the role of endothelin-1 in radiation-associated impotence","volume":"13","author":"Merlin","year":"2001","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib17","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1111\/j.1743-6109.2009.01272.x","article-title":"Changes in the penile arteries of the rat after fractionated irradiation of the prostate: A pilot study","volume":"6","author":"van der Wielen","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib18","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0022-5347(17)38543-9","article-title":"The characterization of a bioassy of erectile function in a rat model","volume":"145","author":"Heaton","year":"1991","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib19","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0091-3057(91)90264-3","article-title":"Metoclopramide decreases apomorphine-induced yawning and penile erection","volume":"38","author":"Heaton","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1740-8261.2012.01986.x","article-title":"Evaluation of canine prostate intrafraction motion using serial cone beam computed tomography imaging","volume":"54","author":"Harmon","year":"2013","journal-title":"Veterinary Radiology & Ultrasound"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib21","unstructured":"Arbuck SG, Ivy SP, Setser A, et al. The revised common toxicity criteria: version 2.0. CTEP Available at: http:\/\/ctep.info.nih.gov. Accessed January 20th, 2015."},{"key":"10.1016\/j.ijrobp.2014.12.025_bib22","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1200\/JCO.2010.31.4377","article-title":"Phase I dose-escalation study of stereotactic body radiation therapy for low- and intermediate-risk prostate cancer","volume":"29","author":"Boike","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/mus.880180406","article-title":"Differentiation between axonal and demyelinating neuropathies: Identical segments recorded from proximal and distal muscles","volume":"18","author":"Raynor","year":"1995","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF00690634","article-title":"Degeneration of non-myelinated axons in the rat sciatic nerve following lysolecithin injection","volume":"56","author":"Mitchell","year":"1982","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib25","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.1464-410X.2004.05106.x","article-title":"Anatomical studies of the neurovascular bundle and cavernosal nerves","volume":"94","author":"Costello","year":"2004","journal-title":"BJU Int"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1464-410X.2006.06266.x","article-title":"The proximal neurovascular plate and the tri-zonal neural architecture around the prostate gland: Importance in the athermal robotic technique of nerve-sparing prostatectomy","volume":"98","author":"Tewari","year":"2006","journal-title":"BJU Int"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib27","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3171\/jns.1996.84.4.0690","article-title":"Paradoxical aggravation of vasospasm with papaverine infusion following aneurysmal subarachnoid hemorrhage: Case report","volume":"84","author":"Clyde","year":"1996","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/STROKEAHA.108.522375","article-title":"Abnormal responses of the human cerebral microcirculation to papaverin during aneurysm surgery","volume":"40","author":"Pennings","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib29","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3171\/jns.1994.81.4.0574","article-title":"The effects of papaverine on phorbon dibutyrate-induced vasoconstriction in brain slice microvessels","volume":"81","author":"Jin","year":"1994","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/09553000903564042","article-title":"Protein kinase C-dependent inhibition of BK(Ca) current in rat aorta smooth muscle cells following gamma-irradiation","volume":"86","author":"Kizub","year":"2010","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib31","doi-asserted-by":"crossref","first-page":"R755","DOI":"10.1152\/ajpregu.00748.2004","article-title":"Ionizing radiation alters myofilament calcium sensitivity in vascular smooth muscle: Potential role of protein kinase C","volume":"289","author":"Soloviev","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib32","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3892\/ijo.2012.1496","article-title":"uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells","volume":"41","author":"Alapati","year":"2012","journal-title":"Int J Oncol"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib33","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1158\/0008-5472.CAN-04-2715","article-title":"Host acid sphingomyelinase regulates microvascular function not tumor immunity","volume":"64","author":"Garcia-Barros","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2014.12.025_bib34","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1126\/science.1082504","article-title":"Tumor response to radiotherapy regulated by endothelial cell apoptosis","volume":"300","author":"Garcia-Barros","year":"2003","journal-title":"Science"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614045258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301614045258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T08:30:32Z","timestamp":1566376232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301614045258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0360301614045258"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.12.025","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pudendal Nerve and Internal Pudendal Artery Damage May Contribute to Radiation-Induced Erectile Dysfunction","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2014.12.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}