{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:05:46Z","timestamp":1791839146904,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.ijrobp.2015.01.029","type":"journal-article","created":{"date-parts":[[2015,4,5]],"date-time":"2015-04-05T18:09:16Z","timestamp":1428257356000},"page":"376-383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Long-term Results of the UCSF-LBNL Randomized Trial: Charged Particle With Helium Ion Versus Iodine-125 Plaque Therapy for Choroidal and Ciliary Body Melanoma"],"prefix":"10.1016","volume":"92","author":[{"given":"Kavita K.","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne M.","family":"Quivey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8336-4042","authenticated-orcid":false,"given":"Inder K.","family":"Daftari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tia B.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1562-118X","authenticated-orcid":false,"given":"Kishan","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore L.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devron H.","family":"Char","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2015.01.029_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/01.iio.0000195853.85581.c0","article-title":"Proton teletherapy of uveal melanoma","volume":"46","author":"Char","year":"2006","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib2","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0360-3016(97)00494-X","article-title":"15 years experience with helium ion radiotherapy for uveal melanoma","volume":"39","author":"Castro","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ijrobp.2012.12.022","article-title":"Long-term results of carbon ion radiation therapy for locally advanced or unfavorably located choroidal melanoma: Usefulness of CT-based 2-port orthogonal therapy for reducing the incidence of NVG","volume":"86","author":"Toyama","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib4","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ijrobp.2005.01.016","article-title":"Proton beam radiotherapy of choroidal melanoma: The Liverpool-Clatterbridge experience","volume":"62","author":"Damato","year":"2005","journal-title":"Int J\u00a0Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0360-3016(99)00147-9","article-title":"Results of proton therapy of uveal melanomas treated in Nice","volume":"45","author":"Courdi","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib6","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1167\/iovs.06-0659","article-title":"Proton beam irradiation of uveal melanomas: The first 30 years\u2014The Weisenfeld Lecture","volume":"47","author":"Gragoudas","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib7","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ijrobp.2006.01.020","article-title":"Proton beam radiotherapy for uveal melanoma: Results of Curie Institut-Orsay proton therapy center","volume":"65","author":"Dendale","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib8","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1177\/112067210901900421","article-title":"Proton beam radiotherapy of uveal melanoma: Italian patients treated in Nice, France","volume":"19","author":"Mosci","year":"2009","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib9","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0161-6420(99)90456-6","article-title":"Comparison of episcleral plaque and proton beam radiation therapy for the treatment of choroidal melanoma","volume":"106","author":"Wilson","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib10","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0360-3016(00)01430-9","article-title":"Proton radiation therapy for medium and large choroidal melanoma: Preservation of the eye and its functionality","volume":"49","author":"Fuss","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0360-3016(01)01560-7","article-title":"Maximizing local tumor control and survival after proton beam radiotherapy of uveal melanoma","volume":"51","author":"Egger","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib12","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/bjophthalmol-2012-302490","article-title":"Local treatment failure after globe-conserving therapy for choroidal melanoma","volume":"97","author":"Chang","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijrobp.2012.08.026","article-title":"Charged particle radiation therapy for uveal melanoma: A systematic review and meta-analysis","volume":"86","author":"Wang","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.radonc.2012.02.001","article-title":"An evidence based review of proton beam therapy: The report of ASTRO's emerging technology committee","volume":"103","author":"Allen","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib15","unstructured":"National Institutes of Health and National Cancer Institute. Planning for a national center for particle beam radiation therapy research (P20), P20 exploratory grant call, posted Oct 17, 2013. Available at: http:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PAR-13-371.html. Accessed July 20, 2014."},{"key":"10.1016\/j.ijrobp.2015.01.029_bib16","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/S0161-6420(93)31446-6","article-title":"Helium-ions versus iodine 125 brachytherapy in the management of uveal melanoma \u2014A prospective, randomized, dynamically balanced trial","volume":"100","author":"Char","year":"1993","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1118\/1.595258","article-title":"Planning proton therapy of the eye","volume":"10","author":"Goitein","year":"1983","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0360-3016(89)90458-6","article-title":"Computer assisted treatment planning for I-125 ophthalmic plaque radiotherapy","volume":"17","author":"Ling","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib19","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0360-3016(03)00006-3","article-title":"The American Brachytherapy Society recommendations for brachytherapy of uveal melanomas","volume":"56","author":"Nag","year":"2003","journal-title":"Int J\u00a0Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib20","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0161-6420(02)01277-0","article-title":"The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: IV. Local treatment failure and enucleation in the first 5 years after\u00a0brachytherapy. COMS report no. 19","volume":"109","author":"Jampol","year":"2002","journal-title":"Ophthalmol"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib21","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.ijrobp.2013.12.014","article-title":"Outcomes of iodine-125 plaque brachytherapy for uveal melanoma with intraoperative ultrasonography and supplemental transpupillary thermotherapy","volume":"88","author":"Badiyan","year":"2014","journal-title":"Int J\u00a0Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib22","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/0360-3016(82)90569-7","article-title":"Treatment of cancer with heavy charged particles","volume":"8","author":"Castro","year":"1982","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2307\/3576804","article-title":"The range of high LET effects from I125 decays","volume":"107","author":"Charlton","year":"1986","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib24","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2356::AID-CNCR26>3.0.CO;2-V","article-title":"I-125 plaque therapy for uveal melanoma: Analysis of the impact of time and dose factors on local control","volume":"77","author":"Quivey","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib25","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/0360-3016(91)90314-T","article-title":"The dose-rate effect revisited: Radiobiological considerations of importance in radiotherapy","volume":"21","author":"Hall","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0360-3016(94)90522-3","article-title":"Dose-rate effects between 0.3 and 30 Gy\/h in a normal and a malignant human cell line","volume":"30","author":"Amdur","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1006\/exer.1993.1162","article-title":"Dose rate effect of 125I irradiation on normal rabbit eyes and experimental choroidal melanoma","author":"Yang","year":"1993","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijrobp.2014.01.026","article-title":"Uveal melanoma treated with iodine-125 episcleral plaque: An analysis of dose on disease control and visual outcomes","volume":"89","author":"Perez","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ijrobp.2013.05.051","article-title":"Risk factors for neovascular glaucoma after proton beam therapy of uveal melanoma: A detailed analysis of tumor and dose-volume parameters","volume":"87","author":"Mishra","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib30","first-page":"1253","article-title":"Helium ion radiation-dosimetry and anterior segment complications","volume":"33","author":"Meecham","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0161-6420(86)33770-9","article-title":"NVG after helium ion irradiation for uveal melanoma","volume":"93","author":"Kim","year":"1986","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib32","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0360-3016(97)00557-9","article-title":"Anterior segment sparing to reduce charged particle radiotherapy complications in uveal melanoma","volume":"39","author":"Daftari","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0168-9002(96)00707-3","article-title":"New UCSF proton ocular beam facility at the Crocker nuclear laboratory cyclotron (UC Davis)","volume":"380","author":"Daftari","year":"1996","journal-title":"Nucl Instrum Methods A"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib34","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S0161-6420(01)00775-8","article-title":"Evidence-based recommendations for the diagnosis and treatment of NVG","volume":"108","author":"Sivak-Callcott","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib35","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1365-2125.2008.03278.x","article-title":"Intravitreal bevacizumab (Avastin (R)) injection for NVG: A survey on 23 cases throughout 12-month follow-up","volume":"66","author":"Costagliola","year":"2008","journal-title":"Brit J Clin Pharmacol"},{"key":"10.1016\/j.ijrobp.2015.01.029_bib36","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1001\/archopht.124.12.1684","article-title":"The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognostic factors: COMS report No. 28","volume":"124","year":"2006","journal-title":"Arch Ophthalmol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301615001212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301615001212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T06:20:39Z","timestamp":1717827639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301615001212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0360301615001212"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2015.01.029","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term Results of the UCSF-LBNL Randomized Trial: Charged Particle With Helium Ion Versus Iodine-125 Plaque Therapy for Choroidal and Ciliary Body Melanoma","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2015.01.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}