{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:09:28Z","timestamp":1789168168451,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.ijrobp.2015.05.039","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T10:46:59Z","timestamp":1433587619000},"page":"344-352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Experimental Studies of Boronophenylalanine (10BPA) Biodistribution for the Individual Application of Boron Neutron Capture Therapy (BNCT) for Malignant Melanoma Treatment"],"prefix":"10.1016","volume":"93","author":[{"given":"Marina","family":"Carpano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Perona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Nievas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8981-366X","authenticated-orcid":false,"given":"Maria","family":"Olivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A.","family":"Santa Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Brandizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romulo","family":"Cabrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Pisarev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo Juan","family":"Juvenal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alejandra","family":"Dagrosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2015.05.039_bib1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1136\/jclinpath-2013-201471","article-title":"Molecular biology of normal melanocytes and melanoma cells","volume":"66","author":"Bandarchi","year":"2013","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib2","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1158\/1078-0432.CCR-05-0035","article-title":"Boron neutron capture therapy of cancer: Current status and future prospects","volume":"11","author":"Barth","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib3","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1748-717X-7-146","article-title":"Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer","volume":"7","author":"Barth","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1600-0749.1989.tb00196.x","article-title":"New thermal neutron capture therapy for malignant melanoma: Melanogenesis-seeking IOB molecule-melanoma cell interaction from in\u00a0vitro to first clinical trial","volume":"2","author":"Mishima","year":"1989","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib5","series-title":"Cancer Neutron Capture Therapy","first-page":"707","article-title":"A phase I dose escalation trial of boron neutron capture therapy for subjects with metastatic subcutaneous melanoma of the extremities","author":"Madoc-Jones","year":"1996"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00008390-199902000-00010","article-title":"Pharmacokinetics of 10B-p-boronophenylalanine in tumours, skin and blood of melanoma patients: A study of boron neutron capture therapy for malignant melanoma","volume":"9","author":"Fukuda","year":"1999","journal-title":"Melanoma Res"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib7","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.apradiso.2009.03.020","article-title":"BNCT for skin melanoma in extremities: Updated Argentine clinical results","volume":"67","author":"Menendez","year":"2009","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib8","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.ijrobp.2004.03.005","article-title":"Role of cell cycle in mediating sensitivity to radiotherapy","volume":"59","author":"Pawlik","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev-genom-082410-101446","article-title":"Personalized medicine: Progress and promise","volume":"12","author":"Chan","year":"2011","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib10","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1600-0749.1989.tb00246.x","article-title":"Characterization of IIB-MEL-J: A new and highly heterogenous human melanoma cell line","volume":"2","author":"Guerra","year":"1989","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib11","series-title":"Guide for the care and use of laboratories animals","year":"1985"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib12","first-page":"559","article-title":"Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131 I-radiolabeled murine monoclonal antibody in a human glioma xenograft model","volume":"48","author":"Lee","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2307\/3579926","article-title":"Biodistribution of boronophenylalanine in patients with glioblastoma multiforme: Boron concentration correlates with tumor cellularity","volume":"149","author":"Coderre","year":"1998","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib14","series-title":"Thermosense: Thermal Infrared Applications XXXIII. Proceedings of SPIE. 8013 SPIE","article-title":"Dynamic infrared imaging for biological and medical applications in boron neutron capture therapy","author":"Santa Cruz","year":"2011"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib15","first-page":"1","article-title":"Microspectrophotometric quantitation of immunohistochemical reactions by image analysis","volume":"22","author":"Brandizzi","year":"2013","journal-title":"Acta Microscopica"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib16","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.apradiso.2004.05.060","article-title":"First BNCT treatment of a skin melanoma in Argentina: Dosimetric analysis and clinical outcome","volume":"61","author":"Gonzalez","year":"2004","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00411-013-0470-0","article-title":"Improvement of the boron neutron capture therapy (BNCT) by the previous administration of the histone deacetylase inhibitor sodium butyrate for the treatment of thyroid carcinoma","volume":"52","author":"Perona","year":"2013","journal-title":"Radiat Environ Biophys"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/lsm.21026","article-title":"Application of a novel boronated porphyrin (H2OCP) as a dual sensitizer for both PDT and BNCT","volume":"43","author":"Hiramatsu","year":"2011","journal-title":"Lasers Surg Med"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib19","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.apradiso.2012.04.005","article-title":"Selective uptake of boronophenylalanine by glioma stem\/progenitor cells","volume":"70","author":"Sun","year":"2012","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib20","doi-asserted-by":"crossref","first-page":"S341","DOI":"10.1016\/j.apradiso.2009.03.059","article-title":"Selective uptake of p-boronophenylalanine by osteosarcoma cells for boron neutron capture therapy","volume":"67","author":"Ferrari","year":"2009","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib21","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/ijc.22808","article-title":"Thermograhic assessment of tumor growth in mouse xenografts","volume":"121","author":"Song","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/BF02820799","article-title":"Differences in thermoregulation between inmunocompetent and immunodeficient hairless mice exposed to mild cold","volume":"43","author":"Funda","year":"1998","journal-title":"Folia Microbiol"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib23","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/S0140-6736(61)91198-9","article-title":"Infra-red thermometry in the diagnosis of breast disease","volume":"2","author":"Lloyd-Williams","year":"1961","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1600-0560.1993.tb00648.x","article-title":"Comparison of proliferative activity as assessed by proliferating cell nuclear antigen (PCNA) and Ki 67 monoclonal antibodies in melanocityc skin lesions","volume":"20","author":"Rieger","year":"1993","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1365-2559.1996.d01-558.x","article-title":"P53 protein and Ki 67 antigen expression are both reliable biomarkers of prognosis in thick stage I nodular melanomas of the skin","volume":"30","author":"Vogt","year":"1997","journal-title":"Histopathology"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/CMR.0b013e32833bd89e","article-title":"The inmunohistochemistry of invasive and proliferative phenotype switching in melanoma: A case report","volume":"20","author":"Eichhoff","year":"2010","journal-title":"Melanoma Res"},{"key":"10.1016\/j.ijrobp.2015.05.039_bib27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/jcp.45.2.143","article-title":"Heterogenity of vascular endothelial cells with relevance to diagnosis of vascular tumors","volume":"45","author":"Kuzu","year":"1992","journal-title":"J Clin Pathol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030161500601X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030161500601X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T22:24:20Z","timestamp":1537568660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036030161500601X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S036030161500601X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2015.05.039","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental Studies of Boronophenylalanine (10BPA) Biodistribution for the Individual Application of Boron Neutron Capture Therapy (BNCT) for Malignant Melanoma Treatment","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2015.05.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}