{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:02:14Z","timestamp":1783749734486,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.ijrobp.2015.11.039","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T03:00:01Z","timestamp":1450234801000},"page":"1144-1153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Bioluminescence Tomography\u2013Guided Radiation Therapy for Preclinical Research"],"prefix":"10.1016","volume":"94","author":[{"given":"Bin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-2898","authenticated-orcid":false,"given":"Ken Kang-Hsin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohrab","family":"Eslami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulian","family":"Iordachita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juvenal","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Malek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuoc T.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2015.11.039_bib1","doi-asserted-by":"crossref","first-page":"14800","DOI":"10.3390\/ijms140714800","article-title":"Molecularly targeted agents as radiosensitizers in cancer therapy\u2013focus on prostate cancer","volume":"14","author":"Alcorn","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1667\/RRXX35.1","article-title":"Using genetically engineered mice for radiation research","volume":"176","author":"Kirsch","year":"2011","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ijrobp.2009.11.008","article-title":"Development of a micro-computed tomography-based image-guided conformal radiotherapy system for small animals","volume":"78","author":"Zhou","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib4","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.ijrobp.2008.04.025","article-title":"High-resolution, small animal radiation research platform with x-ray tomographic guidance capabilities","volume":"71","author":"Wong","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib5","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1088\/0031-9155\/54\/17\/017","article-title":"A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform","volume":"54","author":"Tryggestad","year":"2009","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib6","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1118\/1.3533947","article-title":"Characterization of image quality and image-guidance performance of a preclinical microirradiator","volume":"38","author":"Clarkson","year":"2011","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib7","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1118\/1.2799887","article-title":"MicroRT-small animal conformal irradiator","volume":"34","author":"Stojadinovic","year":"2007","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib8","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1118\/1.2789498","article-title":"Design and evaluation of a variable aperture collimator for conformal radiotherapy of small animals using a microCT scanner","volume":"34","author":"Graves","year":"2007","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib9","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1088\/0031-9155\/56\/8\/016","article-title":"Dosimetric characterization of an image-guided stereotactic small animal irradiator","volume":"56","author":"Pidikiti","year":"2011","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib10","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1088\/0031-9155\/56\/12\/R01","article-title":"Small animal radiotherapy research platforms","volume":"56","author":"Verhaegen","year":"2011","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.zemedi.2014.07.004","article-title":"Pre-clinical research in small animals using radiotherapy technology\u2013a bidirectional translational approach","volume":"24","author":"Tillner","year":"2014","journal-title":"Z Med Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.zemedi.2014.02.004","article-title":"A review of treatment planning for precision image-guided photon beam pre-clinical animal radiation studies","volume":"24","author":"Verhaegen","year":"2014","journal-title":"Z Med Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib13","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1088\/0031-9155\/54\/4\/005","article-title":"Image-guided small animal radiation research platform: Calibration of treatment beam alignment","volume":"54","author":"Matinfar","year":"2009","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1593\/tlo.12136","article-title":"An integrated method for reproducible and accurate image-guided stereotactic cranial irradiation of brain tumors using the small animal radiation research platform","volume":"5","author":"Baumann","year":"2012","journal-title":"Transl Oncol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib15","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1667\/RR2214.1","article-title":"Localized CT-guided irradiation inhibits neurogenesis in specific regions of the adult mouse brain","volume":"175","author":"Ford","year":"2011","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s11060-011-0530-8","article-title":"A radiotherapy technique to limit dose to neural progenitor cell niches without compromising tumor coverage","volume":"104","author":"Redmond","year":"2011","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s40291-013-0062-3","article-title":"Preclinical imaging: An essential ally in modern biosciences","volume":"18","author":"Cunha","year":"2014","journal-title":"Mol Diagn Ther"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib18","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1109\/JPROC.2005.844261","article-title":"Using in\u00a0vivo bioluminescence imaging to shed light on cancer biology","volume":"93","author":"Thorne","year":"2005","journal-title":"Proc IEEE"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/path.2656","article-title":"Bioluminescent imaging: A critical tool in pre-clinical oncology research","volume":"220","author":"O'Neill","year":"2010","journal-title":"J Pathol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3390\/s110100180","article-title":"In\u00a0vivo bioluminescent imaging (BLI): Noninvasive visualization and interrogation of biological processes in living animals","volume":"11","author":"Close","year":"2011","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1359-6446(02)02268-7","article-title":"Whole-animal cellular and molecular imaging to accelerate drug development","volume":"7","author":"Contag","year":"2002","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nbt1074","article-title":"Looking and listening to light: The evolution of whole-body photonic imaging","volume":"23","author":"Ntziachristos","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib23","doi-asserted-by":"crossref","first-page":"7801","DOI":"10.1364\/OE.14.007801","article-title":"In\u00a0vivo mouse studies with bioluminescence tomography","volume":"14","author":"Wang","year":"2006","journal-title":"Opt Express"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib24","doi-asserted-by":"crossref","first-page":"024007","DOI":"10.1117\/1.2717898","article-title":"Three-dimensional reconstruction of\u00a0in\u00a0vivo bioluminescent sources based on multispectral imaging","volume":"12","author":"Kuo","year":"2007","journal-title":"J\u00a0Biomed Opt"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib25","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1118\/1.2982138","article-title":"Spectrally resolved bioluminescence tomography using the reciprocity approach","volume":"35","author":"Dehghani","year":"2008","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib26","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1088\/0031-9155\/59\/1\/R1","article-title":"Small animal fluorescence and bioluminescence tomography: A review of approaches, algorithms and technology update","volume":"59","author":"Darne","year":"2014","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1364\/BOE.2.000169","article-title":"Improved bioluminescence and fluorescence reconstruction algorithms using diffuse optical tomography, normalized data, and optimized selection of the permissible source region","volume":"2","author":"Naser","year":"2011","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib28","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1118\/1.4914860","article-title":"Systematic calibration of an integrated x-ray and optical tomography system for preclinical radiation research","volume":"42","author":"Yang","year":"2015","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib29","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1364\/OL.31.000365","article-title":"Spectrally resolved bioluminescence optical tomography","volume":"31","author":"Dehghani","year":"2006","journal-title":"Opt Lett"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib30","doi-asserted-by":"crossref","first-page":"24825","DOI":"10.1364\/OE.18.024825","article-title":"Sparse reconstruction for quantitative bioluminescence tomography based on the incomplete variables truncated conjugate gradient method","volume":"18","author":"He","year":"2010","journal-title":"Opt Express"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib31","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1364\/BOE.2.003179","article-title":"Bioluminescence tomography using eigenvectors expansion and iterative solution for the optimized permissible source region","volume":"2","author":"Naser","year":"2011","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib32","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1088\/0266-5611\/15\/2\/022","article-title":"Optical tomography in medical imaging","volume":"15","author":"Arridge","year":"1999","journal-title":"Inverse Probl"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib33","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/cnm.1162","article-title":"Near infrared optical tomography using NIRFAST: Algorithm for numerical model and\u00a0image reconstruction","volume":"25","author":"Dehghani","year":"2008","journal-title":"Commun Numer Methods Eng"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib34","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1118\/1.2168293","article-title":"A born-type approximation method for bioluminescence tomography","volume":"33","author":"Cong","year":"2006","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib35","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1364\/BOE.1.000512","article-title":"Algorithms for bioluminescence tomography incorporating anatomical information and reconstruction of tissue optical properties","volume":"1","author":"Naser","year":"2010","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib36","doi-asserted-by":"crossref","first-page":"86007","DOI":"10.1117\/1.JBO.18.8.086007","article-title":"Fast segmentation and high-quality three-dimensional volume mesh creation from medical images for diffuse optical tomography","volume":"18","author":"Jermyn","year":"2013","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mla.2010.04.002","article-title":"Fabrication and characterization of phantoms with tissue-like optical properties from 500 to 700 nm","volume":"25","author":"Pekar","year":"2010","journal-title":"Med Laser Appl"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib38","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1088\/0031-9155\/58\/11\/R37","article-title":"Optical properties of biological tissues: A review","volume":"58","author":"Jacques","year":"2013","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib39","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1088\/0031-9155\/50\/17\/021","article-title":"Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: A computer simulation feasibility study","volume":"50","author":"Alexandrakis","year":"2005","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib40","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1364\/AO.46.002540","article-title":"Validation of luminescent source reconstruction using single-view spectrally resolved bioluminescence images","volume":"46","author":"Virostko","year":"2007","journal-title":"Appl Opt"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1118\/1.3273034","article-title":"In\u00a0vivo bioluminescence tomography with a blocking-off finite-difference SP3 method and MRI\/CT coregistration","volume":"37","author":"Klose","year":"2010","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1593\/tlo.11316","article-title":"Development of a novel preclinical pancreatic cancer research model: Bioluminescence image-guided focal irradiation and tumor monitoring of orthotopic xenografts","volume":"5","author":"Tuli","year":"2012","journal-title":"Transl Oncol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib43","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1667\/RR2999.2","article-title":"Accuracy of off-line bioluminescence imaging to localize targets in preclinical radiation research","volume":"179","author":"Tuli","year":"2013","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1593\/tlo.09184","article-title":"In\u00a0vivo bioluminescent imaging of irradiated orthotopic pancreatic cancer xenografts in nonobese diabetic-severe combined immunodeficient mice: A novel method for targeting and assaying efficacy of ionizing radiation","volume":"3","author":"Lee","year":"2010","journal-title":"Transl Oncol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib45","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/09553002.2014.980468","article-title":"Conventional in\u00a0vivo irradiation procedures are insufficient to accurately determine tumor responses to nonuniform radiation fields","volume":"91","author":"Butterworth","year":"2015","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib46","doi-asserted-by":"crossref","first-page":"102701","DOI":"10.1118\/1.4894730","article-title":"Integration of optical imaging with a small animal irradiator","volume":"41","author":"Weersink","year":"2014","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib47","series-title":"Light Scattering Review 7","first-page":"37","article-title":"Multi-spectral luminescence tomography with the simplified spherical harmonics equations","author":"Klose","year":"2012"},{"key":"10.1016\/j.ijrobp.2015.11.039_bib48","series-title":"Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","first-page":"6904","article-title":"A dual-use imaging system for pre-clinical small animal radiation research","author":"Li","year":"2015"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301615267879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301615267879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T19:04:58Z","timestamp":1599937498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301615267879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0360301615267879"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2015.11.039","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioluminescence Tomography\u2013Guided Radiation Therapy for Preclinical Research","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2015.11.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}