{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:31:32Z","timestamp":1768692692664,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.ijrobp.2016.01.062","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T04:01:34Z","timestamp":1455163294000},"page":"946-955","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical Indicators of Psychosocial Distress Predict for Acute Radiation-Induced Fatigue in Patients Receiving Adjuvant Radiation Therapy for Breast Cancer: An Analysis of Patient-Reported Outcomes"],"prefix":"10.1016","volume":"95","author":[{"given":"Amar U.","family":"Kishan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin-Chieh","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamal","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick A.","family":"Kupelian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A.","family":"McCloskey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2016.01.062_bib1","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1200\/JCO.2000.18.4.743","article-title":"Fatigue in breast cancer survivors: Occurrence, correlates, and impact on quality of life","volume":"18","author":"Bower","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib2","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrclinonc.2014.127","article-title":"Cancer-related fatigue: Mechanisms, risk factors, and treatments","volume":"11","author":"Bower","year":"2014","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib3","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1200\/JCO.2013.53.4495","article-title":"Screening, assessment, and management of fatigue in adult survivors of cancer: An American Society of Clinical oncology clinical practice guideline adaptation","volume":"32","author":"Bower","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S1040-8428(01)00143-3","article-title":"Radiotherapy-related fatigue","volume":"41","author":"Jereczek-Fossa","year":"2002","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/pon.3581","article-title":"Determinants of long-term fatigue in breast cancer survivors: Results of a prospective patient cohort study","volume":"24","author":"Schmidt","year":"2015","journal-title":"Psychooncology"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib6","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jpainsymman.2005.04.012","article-title":"Occurrence, severity, and longitudinal course of twelve common symptoms in 1129 consecutive patients during radiotherapy for cancer","volume":"30","author":"Hickok","year":"2005","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib7","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/0885-3924(92)90106-R","article-title":"Fatigue syndrome due to localized radiation","volume":"7","author":"Greenberg","year":"1992","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib8","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ijrobp.2003.10.008","article-title":"Fatigue during breast radiotherapy and its relationship to biological factors","volume":"59","author":"Wratten","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib9","doi-asserted-by":"publisher","first-page":"5534","DOI":"10.1158\/1078-0432.CCR-08-2584","article-title":"Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer","volume":"15","author":"Bower","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib10","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/bjc.1998.599","article-title":"Fatigue and radiotherapy: (A) experience in patients undergoing treatment","volume":"78","author":"Smets","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3109\/0284186X.2012.742563","article-title":"One-year course of fatigue after post-operative radiotherapy in Norwegian breast cancer patients: Comparison to general population","volume":"52","author":"Reidunsdatter","year":"2013","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib12","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.bbi.2012.09.009","article-title":"Upregulation of alpha-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways","volume":"27","author":"Saligan","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib13","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: When the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib14","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1200\/JCO.2012.46.2143","article-title":"Cytokine genetic variations and fatigue among patients with breast cancer","volume":"31","author":"Bower","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib15","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/nri3042","article-title":"Reciprocal regulation of the neural and innate immune systems","volume":"11","author":"Irwin","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib16","doi-asserted-by":"publisher","first-page":"e275","DOI":"10.1016\/j.prro.2015.01.003","article-title":"Exercise behavior and patient-reported outcomes in women with early breast cancer receiving locoregional radiation therapy","volume":"5","author":"Arya","year":"2015","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib17","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/0973-1482.63566","article-title":"Magnitude of fatigue in cancer patients receiving radiotherapy and its short term effect on quality of life","volume":"6","author":"Janaki","year":"2010","journal-title":"J Cancer Res Ther"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3109\/07357900009023057","article-title":"Fatigue patterns observed in patients receiving chemotherapy and radiotherapy","volume":"18","author":"Schwartz","year":"2000","journal-title":"Cancer Invest"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib19","doi-asserted-by":"publisher","first-page":"4116","DOI":"10.1002\/cncr.26013","article-title":"Comparison of radiation-induced fatigue across 3 different radiotherapeutic methods for early stage breast cancer","volume":"117","author":"Taunk","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib20","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.3109\/0284186X.2011.604345","article-title":"Early effects of contemporary breast radiation on health-related quality of life: Predictors of radiotherapy-related fatigue","volume":"50","author":"Reidunsdatter","year":"2011","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib21","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1037\/0278-6133.26.4.464","article-title":"Utility of a cognitive-behavioral model to predict fatigue following breast cancer treatment","volume":"26","author":"Donovan","year":"2007","journal-title":"Health Psychol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib22","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1093\/annonc\/mdh229","article-title":"Prevalence and course of fatigue in breast cancer patients receiving adjuvant chemotherapy","volume":"15","author":"de Jong","year":"2004","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib23","first-page":"18","article-title":"The patient's experience of fatigue: A cross-sectional study of cancer patients","volume":"5","author":"Henry","year":"2007","journal-title":"J Support Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/01.NCC.0000265005.02559.43","article-title":"Experiences of fatigue and self-management of Thai Buddhist cancer patients undergoing radiation therapy","volume":"30","author":"Lundberg","year":"2007","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib25","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1097\/00006842-200207000-00010","article-title":"Fatigue and proinflammatory cytokine activity in breast cancer survivors","volume":"64","author":"Bower","year":"2002","journal-title":"Psychosom Med"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib26","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1093\/jnci\/djg0019","article-title":"T-cell homeostasis in breast cancer survivors with persistent fatigue","volume":"95","author":"Bower","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib27","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1158\/1078-0432.CCR-05-2398","article-title":"Inflammatory biomarkers for persistent fatigue in breast cancer survivors","volume":"12","author":"Collado-Hidalgo","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib28","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.bbi.2008.05.009","article-title":"Cytokine gene polymorphisms and fatigue in breast cancer survivors: Early findings","volume":"22","author":"Collado-Hidalgo","year":"2008","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib29","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00520-012-1508-6","article-title":"Psychological and immunological characteristics of fatigued women undergoing radiotherapy for early-stage breast cancer","volume":"21","author":"Courtier","year":"2013","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib30","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju244","article-title":"Development of the National Cancer Institute's patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE)","volume":"106","author":"Basch","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib31","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s11136-013-0470-1","article-title":"Cognitive interviewing of the US National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)","volume":"23","author":"Hay","year":"2014","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib32","unstructured":"National Cancer Institute. Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) 2015. Available from: http:\/\/healthcaredelivery.cancer.gov\/pro-ctcae\/. Accessed August 3,\u00a02015."},{"key":"10.1016\/j.ijrobp.2016.01.062_bib33","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/00002820-199804000-00006","article-title":"Fatigue in women with breast cancer receiving radiation therapy","volume":"21","author":"Irvine","year":"1998","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib34","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1200\/JCO.1998.16.5.1689","article-title":"Characteristics and correlates of fatigue after adjuvant chemotherapy for breast cancer","volume":"16","author":"Broeckel","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib35","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/S0885-3924(01)00361-X","article-title":"Fatigue in patients with cancers of the breast or prostate undergoing radical radiotherapy","volume":"22","author":"Stone","year":"2001","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib36","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.1200\/JCO.2011.36.1154","article-title":"Inflammation and behavioral symptoms after breast cancer treatment: Do fatigue, depression, and sleep disturbance share a common underlying mechanism?","volume":"29","author":"Bower","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib37","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1002\/cncr.22993","article-title":"Fatigue after treatment for early stage breast cancer: A controlled comparison","volume":"110","author":"Jacobsen","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib38","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00520-003-0473-5","article-title":"Factors predicting fatigue in breast cancer patients","volume":"11","author":"Haghighat","year":"2003","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib39","doi-asserted-by":"publisher","first-page":"3348","DOI":"10.1245\/s10434-014-3919-8","article-title":"Screening for psychological distress in surgical breast cancer patients","volume":"21","author":"Schubart","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib40","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1001\/jamaoncol.2015.2590","article-title":"Differences in the acute toxic effects of breast radiotherapy by fractionation schedule: Comparative analysis of physician-assessed and patient-reported outcomes in a large multicenter cohort","volume":"1","author":"Jagsi","year":"2015","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib41","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1001\/jamaoncol.2015.2666","article-title":"Acute and short-term toxic effects of conventionally fractionated vs hypofractionated whole-breast irradiation: A randomized clinical trial","volume":"1","author":"Shaitelman","year":"2015","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib42","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.brachy.2009.12.002","article-title":"Partial vs. whole breast irradiation in a community hospital: A retrospective cohort analysis of 200 patients","volume":"9","author":"Ko","year":"2010","journal-title":"Brachytherapy"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib43","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s10549-012-2277-0","article-title":"Explaining age-related differences in depression following breast cancer diagnosis and treatment","volume":"136","author":"Avis","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib44","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/bjc.2014.632","article-title":"The impact of age on changes in quality of life among breast cancer survivors treated with breast-conserving surgery and radiotherapy","volume":"112","author":"Bantema-Joppe","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib45","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S0360-3016(01)01657-1","article-title":"Fatigue, serum cytokine levels, and blood cell counts during radiotherapy of patients with breast cancer","volume":"51","author":"Geinitz","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.01.062_bib46","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1200\/JCO.2008.19.4225","article-title":"Trends in mastectomy rates at the Mayo Clinic Rochester: Effect of surgical year and preoperative magnetic resonance imaging","volume":"27","author":"Katipamula","year":"2009","journal-title":"J Clin Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616001309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616001309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T14:21:21Z","timestamp":1537021281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301616001309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0360301616001309"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.01.062","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Indicators of Psychosocial Distress Predict for Acute Radiation-Induced Fatigue in Patients Receiving Adjuvant Radiation Therapy for Breast Cancer: An Analysis of Patient-Reported Outcomes","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.01.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}