{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:24:44Z","timestamp":1790645084300,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.ijrobp.2016.03.015","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T08:54:47Z","timestamp":1458377687000},"page":"1117-1131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["Reirradiation of Head and Neck Cancers With Intensity Modulated Radiation Therapy: Outcomes and Analyses"],"prefix":"10.1016","volume":"95","author":[{"given":"Vinita","family":"Takiar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Garden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Edson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Zafereo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary B.","family":"Gunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton D.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Beadle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William N.","family":"William","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merrill","family":"Kies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel K.","family":"El-Naggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2016.03.015_bib1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00066-010-2130-5","article-title":"Pattern of failure after helical tomotherapy in head and neck cancer","volume":"186","author":"Farrag","year":"2010","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0360-3016(02)03940-8","article-title":"Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer","volume":"55","author":"Chao","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib3","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ijrobp.2005.07.005","article-title":"Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma","volume":"64","author":"Salama","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl. 7","key":"10.1016\/j.ijrobp.2016.03.015_bib4","doi-asserted-by":"crossref","first-page":"vii252","DOI":"10.1093\/annonc\/mdq453","article-title":"Optimal treatment for recurrent\/metastatic head and neck cancer","volume":"21","author":"Vermorken","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib5","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1200\/JCO.1992.10.8.1245","article-title":"Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: A Southwest Oncology Group Study","volume":"10","author":"Forastiere","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1200\/JCO.1992.10.2.257","article-title":"A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck","volume":"10","author":"Jacobs","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib7","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ijrobp.2006.08.078","article-title":"Disease-control rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma","volume":"67","author":"Garden","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ijrobp.2008.04.021","article-title":"IMRT reirradiation of head and neck cancer-disease control and morbidity outcomes","volume":"73","author":"Sulman","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib9","first-page":"72","article-title":"Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival","volume":"62","author":"Wittekindt","year":"2005","journal-title":"Adv Otorhinolaryngol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib10","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1200\/JCO.2006.07.9194","article-title":"Phase II study of low-dose paclitaxel and cisplatin in combination with split-course concomitant twice-daily reirradiation in recurrent squamous cell carcinoma of the head and neck: Results of Radiation Therapy Oncology Group protocol 9911","volume":"25","author":"Langer","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/hed.20697","article-title":"Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck","volume":"30","author":"Spencer","year":"2008","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib12","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1002\/cncr.26084","article-title":"Prior chemoradiotherapy adversely impacts outcomes of recurrent and second primary head and neck cancer treated with concurrent chemotherapy and reirradiation","volume":"117","author":"Choe","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib13","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/oxfordjournals.annonc.a010793","article-title":"Re-irradiation with concomitant chemotherapy of unresectable recurrent head and neck cancer: A potentially curable disease","volume":"7","author":"Haraf","year":"1996","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib14","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0360-3016(01)01745-X","article-title":"RTOG 96-10: Reirradiation with concurrent hydroxyurea and 5-fluorouracil in patients with squamous cell cancer of the head and neck","volume":"51","author":"Spencer","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib15","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1200\/JCO.1998.16.11.3556","article-title":"Full-dose reirradiation for unresectable head and neck carcinoma: Experience at the Gustave-Roussy Institute in a series of 169 patients","volume":"16","author":"De Crevoisier","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib16","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1200\/JCO.2007.15.0102","article-title":"Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck carcinoma","volume":"26","author":"Janot","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib17","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0360-3016(01)01599-1","article-title":"Extent and kinetics of recovery of occult spinal cord injury","volume":"50","author":"Ang","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib18","first-page":"585","article-title":"A phase II trial of docetaxel, cisplatin and 5-fluorouracil in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN)","volume":"26","author":"Baghi","year":"2006","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.radonc.2010.10.025","article-title":"Hypofractionated accelerated CT-guided interstitial 192Ir-HDR-brachytherapy as re-irradiation in inoperable recurrent cervical lymphadenopathy from head and neck cancer","volume":"98","author":"Tselis","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib20","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0360-3016(88)90297-0","article-title":"Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy","volume":"15","author":"Weichselbaum","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/hed.20502","article-title":"Histologic characteristics and tumor spread of recurrent glottic carcinoma: Analysis on whole-organ sections and comparison with tumor spread of primary glottic carcinomas","volume":"29","author":"Zbaren","year":"2007","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib22","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.ijrobp.2008.12.075","article-title":"Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: Results of a phase I dose-escalation trial","volume":"75","author":"Heron","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/COC.0b013e3181dbb73e","article-title":"Concurrent cetuximab with stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: A single institution matched case-control study","volume":"34","author":"Heron","year":"2011","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib24","first-page":"1349","article-title":"Examining tumor control and toxicity after stereotactic body radiotherapy in locally recurrent previously irradiated head and neck cancers: Implications of treatment duration and tumor volume","volume":"36","author":"Vargo","year":"2014","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0360-3016(03)00074-9","article-title":"Linear accelerator-based stereotactic radiosurgery for limited, locally persistent, and recurrent nasopharyngeal carcinoma: Efficacy and complications","volume":"56","author":"Chua","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib26","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/hed.20338","article-title":"Stereotactic radiosurgery plus intracavitary irradiation in\u00a0the salvage of nasopharyngeal carcinoma","volume":"28","author":"Low","year":"2006","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib27","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/hed.23798","article-title":"Long term follow up of stereotactic radiosurgery for head and neck malignancies","volume":"37","author":"Owen","year":"2015","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2016.03.015_bib28","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.ijrobp.2011.02.014","article-title":"ACR appropriateness criteria retreatment of recurrent head and neck cancer after prior definitive radiation expert panel on radiation oncology-head and neck cancer","volume":"80","author":"McDonald","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616003278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616003278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T14:09:34Z","timestamp":1655302174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301616003278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0360301616003278"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.03.015","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reirradiation of Head and Neck Cancers With Intensity Modulated Radiation Therapy: Outcomes and Analyses","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}