{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:31:00Z","timestamp":1775910660957,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.ijrobp.2016.06.009","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T06:26:55Z","timestamp":1466058415000},"page":"280-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Stereotactic Radiosurgery for Brainstem Metastases: An International Cooperative Study to Define Response and Toxicity"],"prefix":"10.1016","volume":"96","author":[{"given":"Daniel M.","family":"Trifiletti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Chia","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Kano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Janopaul-Naylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Alonso-Basanta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Y.K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Simonova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Liscak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Kvint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga S.","family":"Grills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang-Du","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Jung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"France","family":"H\u00e9roux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayur","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Cifarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher N.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Hack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Golfinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Kondziolka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Dade","family":"Lunsford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason P.","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2016.06.009_bib1","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0140-6736(04)16250-8","article-title":"Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomised trial","volume":"363","author":"Andrews","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib2","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S1470-2045(09)70263-3","article-title":"Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: A randomised controlled trial","volume":"10","author":"Chang","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib3","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJM199002223220802","article-title":"A randomized trial of surgery in the treatment of single metastases to the brain","volume":"322","author":"Patchell","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11060-009-0073-4","article-title":"The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline","volume":"96","author":"Linskey","year":"2010","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0360-3016(99)00507-6","article-title":"Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: Final report of RTOG protocol 90-05","volume":"47","author":"Shaw","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib6","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0360-3016(02)04379-1","article-title":"A comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastases","volume":"55","author":"O'Neill","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1200\/JCO.2010.30.1655","article-title":"Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952-26001 study","volume":"29","author":"Kocher","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib8","unstructured":"Brown PD. N0574: Stereotactic radiation therapy with or without whole-brain radiation therapy in treating patients with brain metastases. Available at: http:\/\/meetinglibrary.asco.org\/content\/146056-156. Accessed February 19, 2015."},{"key":"10.1016\/j.ijrobp.2016.06.009_bib9","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1227\/01.NEU.0000325726.72815.22","article-title":"Radiation tolerance limits of the brainstem","volume":"63","author":"Sharma","year":"2008","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib10","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.ijrobp.2009.08.078","article-title":"Radiation associated brainstem injury","volume":"76","author":"Mayo","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11060-007-9458-4","article-title":"Gamma knife radiosurgery for brainstem metastases: The UCSF experience","volume":"86","author":"Kased","year":"2008","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ijrobp.2009.07.1750","article-title":"Stereotactic radiosurgery for single brainstem metastases: The Cleveland Clinic experience","volume":"78","author":"Koyfman","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib13","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1227\/NEU.0b013e31821d31de","article-title":"Outcomes and prognostic factors for patients with brainstem metastases undergoing stereotactic radiosurgery","volume":"69","author":"Hatiboglu","year":"2011","journal-title":"Neurosurgery"},{"issue":"Suppl.","key":"10.1016\/j.ijrobp.2016.06.009_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3171\/2012.7.GKS12977","article-title":"Gamma Knife surgery for patients with brainstem metastases","volume":"117","author":"Kawabe","year":"2012","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11060-013-1086-6","article-title":"Treatment of brainstem metastases with gamma-knife radiosurgery","volume":"113","author":"Sengoz","year":"2013","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib16","doi-asserted-by":"crossref","first-page":"9748","DOI":"10.3390\/ijms15069748","article-title":"Gamma knife treatment of brainstem metastases","volume":"15","author":"Peterson","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11060-014-1373-x","article-title":"Local control and toxicity outcomes in brainstem metastases treated with single fraction radiosurgery: Is there a volume threshold for toxicity?","volume":"117","author":"Kilburn","year":"2014","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib18","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1227\/NEU.0b013e31823c40fe","article-title":"Accelerator-based stereotactic radiosurgery for brainstem metastases","volume":"70","author":"Lin","year":"2012","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3171\/jns.2006.105.2.213","article-title":"Gamma knife surgery for metastatic brainstem tumors","volume":"105","author":"Yen","year":"2006","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.surneu.2008.01.029","article-title":"Brain stem metastases treated with radiosurgery: Prognostic factors of survival and life expectancy estimation","volume":"71","author":"Lorenzoni","year":"2009","journal-title":"Surg Neurol"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1748-717X-7-107","article-title":"Prescription dose and fractionation predict improved survival after stereotactic radiotherapy for brainstem metastases","volume":"7","author":"Leeman","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib22","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00701-003-0034-1","article-title":"Gamma knife radiosurgery for metastatic tumours in the brain stem","volume":"145","author":"Shuto","year":"2003","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib23","unstructured":"National Insitutes of Health, National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE), Version 4.0. Available at: http:\/\/evs.nci.nih.gov\/ftp1\/CTCAE\/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf. Accessed July 22,\u00a02015."},{"key":"10.1016\/j.ijrobp.2016.06.009_bib24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3171\/jns.2006.104.1.157","article-title":"Assessment of imaging studies used with radiosurgery: A volumetric algorithm and an estimation of its error. Technical note","volume":"104","author":"Snell","year":"2006","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib25","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ijrobp.2005.08.035","article-title":"Stereotactic radiosurgery for four or more intracranial metastases","volume":"64","author":"Bhatnagar","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib26","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ijrobp.2010.02.028","article-title":"Minimized doses for linear accelerator radiosurgery of brainstem metastasis","volume":"80","author":"Valery","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib27","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3171\/jns.1999.91.4.0563","article-title":"Stereotactic radiosurgery for brainstem metastases","volume":"91","author":"Huang","year":"1999","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3340\/jkns.2011.50.4.299","article-title":"Gamma knife radiosurgery for brainstem metastasis","volume":"50","author":"Yoo","year":"2011","journal-title":"J Korean Neurosurg Soc"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib29","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s11060-010-0514-0","article-title":"Linear accelerator-based stereotactic radiosurgery for brainstem metastases: The Dana-Farber\/Brigham and Women's Cancer Center experience","volume":"104","author":"Kelly","year":"2011","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib30","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.clineuro.2013.06.012","article-title":"Gamma Knife radiosurgery in the management of brainstem metastases","volume":"115","author":"Jung","year":"2013","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.ijrobp.2016.06.009_bib31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.wneu.2015.10.089","article-title":"How does brainstem involvement affect prognosis in patients with limited brain metastases? Results of a matched-cohort analysis","volume":"88","author":"Trifiletti","year":"2016","journal-title":"World Neurosurg"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616303200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616303200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T20:17:12Z","timestamp":1568060232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301616303200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0360301616303200"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.06.009","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stereotactic Radiosurgery for Brainstem Metastases: An International Cooperative Study to Define Response and Toxicity","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}