{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:12:56Z","timestamp":1792141976744,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.ijrobp.2016.07.025","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:16:54Z","timestamp":1469704614000},"page":"832-839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Total Body Irradiation Schedule Affects Acute Leukemia Relapse After Matched T Cell\u2013Depleted Hematopoietic Stem Cell Transplantation"],"prefix":"10.1016","volume":"96","author":[{"given":"Cynthia","family":"Aristei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Carotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Palazzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Ruggeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Perrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Falcinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Lancellotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Falzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Aversa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Merluzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Velardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo Fabrizio","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2016.07.025_bib1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1182\/blood.V91.3.1083","article-title":"T-cell-depleted allogeneic bone marrow transplantation as postremission therapy for acute myelogenous leukemia: Freedom from relapse in the absence of graft-versus-host disease","volume":"91","author":"Papadopoulos","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib2","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1200\/JCO.1999.17.5.1545","article-title":"Improved outcome with T-cell-depleted bone marrow transplantation for acute leukemia","volume":"17","author":"Aversa","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib3","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0360-3016(81)90162-0","article-title":"The effect of fractionated versus unfractionated total body irradiation on the growth of the BN acute myelocytic leukemia","volume":"7","author":"Hagenbeek","year":"1981","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0360-3016(91)90081-E","article-title":"What does total body irradiation do in bone marrow transplants for leukemia?","volume":"20","author":"Gale","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib5","series-title":"Textbook of Radiation Oncology","first-page":"253","article-title":"Total body irradiation","author":"Shank","year":"1998"},{"issue":"Suppl 1","key":"10.1016\/j.ijrobp.2016.07.025_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0167-8140(90)90177-X","article-title":"Prediction of effects of therapeutic total body irradiation in man","volume":"18","author":"Vriesendorp","year":"1990","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0360-3016(94)90031-0","article-title":"Single dose versus fractionated total body irradiation before bone marrow transplantation: Radiobiological and clinical considerations","volume":"30","author":"Cosset","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/bmt.2010.280","article-title":"TBI during BM and SCT: Review of the past, discussion of the present and consideration of future directions","volume":"46","author":"Hill-Kayser","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib9","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/bmt.2013.66","article-title":"In haematopoietic SCT for acute leukemia TBI impacts on relapse but not survival: Results of a multicentre observational study","volume":"48","author":"Aristei","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib10","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1056\/NEJM199810223391702","article-title":"Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype","volume":"339","author":"Aversa","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib11","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1200\/JCO.2005.09.117","article-title":"Full haplotype-mismatched hematopoietic stem-cell transplantation: A phase II study in patients with acute leukemia at high risk of relapse","volume":"23","author":"Aversa","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bbmt.2005.09.004","article-title":"National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report","volume":"11","author":"Filipovich","year":"2005","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib13","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1214\/aos\/1176350951","article-title":"A class of K-sample tests for comparing the cumulative incidence of a competing risk","volume":"16","author":"Gray","year":"1988","journal-title":"Ann Stat"},{"issue":"Suppl 1","key":"10.1016\/j.ijrobp.2016.07.025_bib14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0167-8140(90)90180-5","article-title":"Total body irradiation for bone marrow transplantation: The Memorial Sloan-Kettering Cancer Center experience","volume":"18","author":"Shank","year":"1990","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib15","first-page":"330","article-title":"Allogeneic matched T-cell-depleted bone marrow transplantation for acute leukemia patients","volume":"2","author":"Aristei","year":"1996","journal-title":"Cancer J Sci Am"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib16","first-page":"3101","article-title":"Efficacy of fludarabine as an immunosuppressor for bone marrow transplantation conditioning: Preliminary results","volume":"28","author":"Terenzi","year":"1996","journal-title":"Transplant Proc"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib17","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1182\/blood.V77.3.661.661","article-title":"Syngeneic and allogeneic bone marrow engraftment after total body irradiation: Dependence on dose, dose rate, and fractionation","volume":"77","author":"Down","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib18","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1182\/blood.V83.11.3384.3384","article-title":"Fractionated versus single-dose total body irradiation at low and high dose rates to condition canine littermates for DLA-identical marrow grafts","volume":"83","author":"Storb","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib19","first-page":"3217","article-title":"Comparison of immunosuppressive effects of single-dose and hyperfractionated total body irradiation","volume":"26","author":"Terenzi","year":"1994","journal-title":"Transplant Proc"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0167-8140(00)00333-9","article-title":"Total body irradiation-based regimen in the conditioning of patients submitted to haploidentical stem cell transplantation","volume":"58","author":"Aristei","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/030089160108700610","article-title":"The role of total body irradiation in the conditioning of patients receiving haploidentical stem cell transplantation","volume":"87","author":"Aristei","year":"2001","journal-title":"Tumori"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib22","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0360-3016(80)90241-2","article-title":"Total Body Irradiation Conference: Discussion: The radiobiological bases of TBI","volume":"6","author":"Peters","year":"1980","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib23","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/0360-3016(91)90332-X","article-title":"Radiation sensitivity of human B-lineage lymphoid precursor cells","volume":"21","author":"Uckun","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0360-3016(92)90718-W","article-title":"Immunophenotype predicts radiation resistance in T-lineage acute lymphoblastic leukemia and T-lineage non-Hodgkin's lymphoma","volume":"24","author":"Uckun","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib25","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0360-3016(90)90009-9","article-title":"Comparison of two total body irradiation regimens in allogeneic bone marrow transplantation for acute non-lymphoblastic leukemia in first remission","volume":"19","author":"Kim","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0167-8140(89)90129-1","article-title":"Single dose versus hyperfractionated total body irradiation before allogeneic bone marrow transplantation: A non-randomized comparative study of 54 patients at the Institut Gustave-Roussy","volume":"15","author":"Cosset","year":"1989","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib27","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0360-3016(94)00446-R","article-title":"Fractionated or single-dose total body irradiation in 171 acute myeloblastic leukemias in first complete remission: Is there a best choice?","volume":"31","author":"Resbeut","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00007890-198703000-00014","article-title":"Allogeneic bone marrow transplantation for acute lymphoblastic leukemia during first complete remission","volume":"43","author":"Blume","year":"1987","journal-title":"Transplantation"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib29","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1182\/blood.V78.8.2120.2120","article-title":"T-cell depletion of HLA-identical transplants in leukemia","volume":"78","author":"Marmont","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib30","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/0360-3016(90)90220-E","article-title":"Fractionated total body irradiation and bone marrow transplantation in acute lymphoblastic leukemia","volume":"19","author":"Altschuler","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib31","first-page":"583","article-title":"Allogeneic bone marrow transplantation for adult acute lymphoblastic leukemia in first complete remission: Factors predictive of transplant-related mortality and influence of total body irradiation modalities","volume":"12","author":"Sutton","year":"1993","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0360-3016(94)90355-7","article-title":"Consequences of two different doses to the lungs during a single dose of total body irradiation: Results of a randomized study on 85 patients","volume":"30","author":"Girinsky","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib33","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0360-3016(98)00068-6","article-title":"Interstitial pneumonitis in acute leukemia patients submitted to T-depleted matched and mismatched bone marrow transplantation","volume":"41","author":"Aristei","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib34","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/0360-3016(83)90412-1","article-title":"Hyperfractionated total body irradiation for bone marrow transplantation. Results in seventy leukemia patients with allogeneic transplants","volume":"9","author":"Shank","year":"1983","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.07.025_bib35","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0360-3016(82)90083-9","article-title":"Marrow transplantation for acute nonlymphoblastic leukemia in first remission using fractionated or single-dose irradiation","volume":"8","author":"Thomas","year":"1982","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616329005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616329005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T01:24:56Z","timestamp":1656897896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301616329005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0360301616329005"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.07.025","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Total Body Irradiation Schedule Affects Acute Leukemia Relapse After Matched T Cell\u2013Depleted Hematopoietic Stem Cell Transplantation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}