{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:58:47Z","timestamp":1787741927223,"version":"build-2784847793"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.ijrobp.2016.11.022","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T20:09:48Z","timestamp":1479931788000},"page":"786-796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["A Randomized Phase 2 Trial of Prophylactic Manuka Honey for the Reduction of Chemoradiation Therapy\u2013Induced Esophagitis During the Treatment of Lung Cancer: Results of NRG Oncology RTOG 1012"],"prefix":"10.1016","volume":"97","author":[{"given":"Shannon E.","family":"Fogh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence B.","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amylou C.","family":"Dueck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Roof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Yacoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gergel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Stephans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rimner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"DeNittis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pablo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Rineer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Bruner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2016.11.022_bib1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0360-3016(00)00699-4","article-title":"Predictors of severe esophagitis include use of concurrent chemotherapy, but not the length of irradiated esophagus: A multivariate analysis of patients with lung cancer treated with nonoperative therapy","volume":"48","author":"Werner-Wasik","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib2","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0360-3016(98)00251-X","article-title":"Response, toxicity, failure patterns, and survival in five radiation therapy oncology group (RTOG) trials of sequential and\/or concurrent chemotherapy and radiotherapy for locally advanced non-small-cell carcinoma of the lung","volume":"42","author":"Byhardt","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib3","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0360-3016(99)00031-0","article-title":"Interfraction interval does not affect survival of patients with non-small cell lung cancer treated with chemotherapy and\/or hyperfractionated radiotherapy: A multivariate analysis of 1076 RTOG patients","volume":"44","author":"Werner-Wasik","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib4","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/0360-3016(94)E0021-B","article-title":"A phase III study of accelerated radiotherapy with and without carboplatin in nonsmall cell lung cancer: An interim toxicity analysis of the first 100 patients","volume":"31","author":"Ball","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib5","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S1053-4296(96)80005-1","article-title":"Three-dimensional conformal radiation therapy in bronchogenic carcinoma","volume":"6","author":"Emami","year":"1996","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib6","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.meddos.2004.03.019","article-title":"Comparison of three IMRT inverse planning techniques that allow for partial esophagus sparing in patients receiving thoracic radiation therapy for lung cancer","volume":"29","author":"Xiao","year":"2004","journal-title":"Med Dosim"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib7","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1056\/NEJM199901283400403","article-title":"Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide","volume":"340","author":"Turrisi","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0360-3016(86)90096-9","article-title":"Protection of acute and late radiation damage of the gastrointestinal tract by WR-2721","volume":"12","author":"Ito","year":"1986","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib9","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3816\/CLC.2001.n.011","article-title":"Preliminary report on reduction of esophagitis by amifostine in patients with non-small-cell lung cancer treated with chemoradiotherapy","volume":"2","author":"Werner-Wasik","year":"2001","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1053\/srao.2002.31361","article-title":"Phase II: Trial of twice weekly amifostine in patients with non-small cell lung cancer treated with chemoradiotherapy","volume":"12","author":"Werner-Wasik","year":"2002","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib11","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0360-3016(95)02102-7","article-title":"The impact of overall treatment time on the results of radiotherapy for nonsmall cell lung carcinoma","volume":"34","author":"Koukourakis","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib12","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/S0360-3016(01)01713-8","article-title":"Randomized phase III trial of radiation treatment +\/- amifostine in patients with advanced-stage lung cancer","volume":"51","author":"Antonadou","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1053\/srao.2002.31374","article-title":"Radiotherapy or chemotherapy followed by radiotherapy with or without amifostine in locally advanced lung cancer","volume":"12","author":"Antonadou","year":"2002","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib14","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1200\/JCO.2005.07.167","article-title":"Randomized trial of amifostine in locally advanced non-small-cell lung cancer patients receiving chemotherapy and hyperfractionated radiation: Radiation Therapy Oncology Group trial 98-01","volume":"23","author":"Movsas","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib15","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0273-1177(92)90116-F","article-title":"Radiation protection against early and late effects of ionizing irradiation by the prostaglandin inhibitor indomethacin","volume":"12","author":"Milas","year":"1992","journal-title":"Adv Space Res"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0167-8140(85)80005-0","article-title":"Prophylactic administration of indomethacin for irradiation esophagitis","volume":"3","author":"Nicolopoulos","year":"1985","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib17","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00268-003-7073-x","article-title":"Special wound healing methods used in ancient Egypt and the mythological background","volume":"28","author":"Sipos","year":"2004","journal-title":"World J Surg"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib18","first-page":"831","article-title":"Wound healing with honey: A randomised controlled trial","volume":"96","author":"Ingle","year":"2006","journal-title":"S Afr Med J"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib19","first-page":"44","article-title":"A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers","volume":"63","author":"Shukrimi","year":"2008","journal-title":"Med J Malaysia"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1097\/01.WON.0000264833.11108.35","article-title":"Effectiveness of a honey dressing for healing pressure ulcers","volume":"34","author":"Yapucu G\u00fcne\u015f","year":"2007","journal-title":"J Wound Ostomy Continence Nurs"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib21","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1089\/acm.2005.11.511","article-title":"Comparison of healing of incised abscess wounds with honey and eusol dressing","volume":"11","author":"Okeniyi","year":"2005","journal-title":"J Altern Complement Med"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib22","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1089\/1096620041224139","article-title":"Investigating the antimicrobial activity of natural honey and its effects on the pathogenic bacterial infections of surgical wounds and conjunctiva","volume":"7","author":"Al-Waili","year":"2004","journal-title":"J Med Food"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib23","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.arcmed.2005.03.038","article-title":"Bactericidal activity of different honeys against pathogenic bacteria","volume":"36","author":"Lusby","year":"2005","journal-title":"Arch Med Res"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib24","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s00520-003-0443-y","article-title":"Topical application of honey in the management of radiation mucositis: A preliminary study","volume":"11","author":"Biswal","year":"2003","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5005\/jcdp-9-3-40","article-title":"The effect of topical application of pure honey on radiation-induced mucositis: A randomized clinical trial","volume":"9","author":"Motallebnejad","year":"2008","journal-title":"J Contemp Dent Pract"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1017\/S0022215108002478","article-title":"Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer","volume":"123","author":"Rashad","year":"2009","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib27","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.ijom.2010.05.014","article-title":"Effect of topical honey on limitation of radiation-induced oral mucositis: An intervention study","volume":"39","author":"Khanal","year":"2010","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib28","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/0021-9681(74)90015-0","article-title":"The randomization and stratification of patients to clinical trials","volume":"27","author":"Zelen","year":"1974","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib29","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1111\/j.2042-7158.1991.tb03186.x","article-title":"A survey of the antibacterial activity of some New Zealand honeys","volume":"43","author":"Allen","year":"1991","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/014107689408700106","article-title":"Susceptibility of Helicobacter pylori to the antibacterial activity of manuka honey","volume":"87","author":"al Somal","year":"1994","journal-title":"J R Soc Med"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib31","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/j.1365-2672.1992.tb04993.x","article-title":"A comparison of the sensitivity of wound-infecting species of bacteria to the antibacterial activity of manuka honey and other honey","volume":"73","author":"Willix","year":"1992","journal-title":"J Appl Bacteriol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib32","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1007\/BF01921753","article-title":"The sterilization of honey with cobalt 60 gamma radiation: A study of honey spiked with spores of Clostridium botulinum and Bacillus subtilis","volume":"51","author":"Postmes","year":"1995","journal-title":"Experientia"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib33","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1111\/j.2042-7158.1996.tb03922.x","article-title":"The effect of gamma-irradiation on the antibacterial activity of honey","volume":"48","author":"Molan","year":"1996","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib34","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0304-3959(99)00101-3","article-title":"Comparative reliability and validity of chronic pain intensity measures","volume":"83","author":"Jensen","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib35","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib36","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju244","article-title":"Development of the National Cancer Institute's patient-reported outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)","volume":"106","author":"Basch","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib37","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1001\/jamaoncol.2015.2639","article-title":"Validity and reliability of the us national cancer institute's patient-reported outcomes version of the common terminology criteria for adverse events (pro-ctcae)","volume":"1","author":"Dueck","year":"2015","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib38","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju129","article-title":"Recommended patient-reported core set of symptoms to measure in adult cancer treatment trials","volume":"106","author":"Reeve","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib39","doi-asserted-by":"publisher","first-page":"241","DOI":"10.12968\/jowc.2008.17.6.29583","article-title":"Bacteriological changes in sloughy venous leg ulcers treated with manuka honey or hydrogel: An rct","volume":"17","author":"Gethin","year":"2008","journal-title":"J Wound Care"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib40","doi-asserted-by":"publisher","first-page":"707","DOI":"10.3109\/13693780802572554","article-title":"Antifungal activity of turkish honey against candida spp. And trichosporon spp: An in\u00a0vitro evaluation","volume":"47","author":"Koc","year":"2009","journal-title":"Med Mycol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib41","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1080\/13693780500417037","article-title":"Honey has an antifungal effect against candida species","volume":"44","author":"Irish","year":"2006","journal-title":"Med Mycol"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib42","first-page":"MT94","article-title":"Topical honey application vs. Acyclovir for the treatment of recurrent herpes simplex lesions","volume":"10","author":"Al-Waili","year":"2004","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib43","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.ijrobp.2008.03.003","article-title":"Clinically meaningful differences in patient-reported outcomes with amifostine in combination with chemoradiation for locally advanced non-small-cell lung cancer: An analysis of rtog 9801","volume":"72","author":"Sarna","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.11.022_bib44","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1128\/jcm.9.2.282-283.1979","article-title":"Isolation of clostridium botulinum from honey","volume":"9","author":"Midura","year":"1979","journal-title":"J Clin Microbiol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616334800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616334800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:18:48Z","timestamp":1692580728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301616334800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0360301616334800"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.11.022","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Randomized Phase 2 Trial of Prophylactic Manuka Honey for the Reduction of Chemoradiation Therapy\u2013Induced Esophagitis During the Treatment of Lung Cancer: Results of NRG Oncology RTOG 1012","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}