{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:15:39Z","timestamp":1787066139401,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.ijrobp.2016.12.028","type":"journal-article","created":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T02:16:45Z","timestamp":1482718605000},"page":"1054-1060","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Multicenter Study of Carbon-Ion Radiation Therapy for Mucosal Melanoma of the Head and Neck: Subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) Study (1402 HN)"],"prefix":"10.1016","volume":"97","author":[{"given":"Masashi","family":"Koto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Demizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Suefuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Okimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Shioyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2016.12.028_bib1","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G","article-title":"The National Cancer Data Base report on cutaneous and noncutaneous melanoma: A summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society","volume":"83","author":"Chang","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2273.1998.00099.x","article-title":"Mucosal melanoma of the head and neck","volume":"23","author":"Nandapalan","year":"1998","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib3","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1001\/archotol.129.8.864","article-title":"The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region","volume":"129","author":"Owens","year":"2003","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/MOO.0b013e3283374d31","article-title":"Management of mucosal melanomas of the head and neck: Did we make any progress?","volume":"18","author":"Moreno","year":"2010","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib5","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/hed.2890040509","article-title":"The pathology of head and neck tumors: Mucosal melanomas, part 13","volume":"4","author":"Batsakis","year":"1982","journal-title":"Head Neck Surg"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4193\/Rhin12.075","article-title":"Primary sinonasal malignant melanoma: A nationwide study of the Swedish population, 1960-2000","volume":"51","author":"Jangard","year":"2013","journal-title":"Rhinology"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib7","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1245\/s10434-011-1685-4","article-title":"Predictors of survival in mucosal melanoma of the head and neck","volume":"18","author":"Jethanamest","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib8","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ijrobp.2014.03.042","article-title":"Mucosal melanoma of the head and neck: A systematic review of the literature","volume":"90","author":"Lazarev","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00066-007-1616-2","article-title":"Local high-dose radiotherapy and sparing of normal tissue using intensity-modulated radiotherapy (IMRT) for mucosal melanoma of the nasal cavity and paranasal sinuses","volume":"183","author":"Combs","year":"2007","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ijrobp.2003.11.013","article-title":"A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan","volume":"59","author":"Wada","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijrobp.2008.07.056","article-title":"Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy","volume":"74","author":"Yanagi","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib12","series-title":"TNM Classification of Malignant Tumors","year":"2009"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib13","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1088\/0031-9155\/60\/8\/3271","article-title":"Reformulation of a clinical-dose system for carbon-ion radiotherapy treatment planning at the National Institute of Radiological Sciences, Japan","volume":"60","author":"Inaniwa","year":"2015","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/cncr.20775","article-title":"Postoperative radiotherapy for primary mucosal melanoma of the head and neck","volume":"103","author":"Temam","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1288\/00005537-199402000-00001","article-title":"Mucosal melanoma of the head and neck: The impact of local control on survival","volume":"104","author":"Lee","year":"1994","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib16","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1097\/01.mlg.0000217236.06585.a9","article-title":"Primary mucosal melanoma of head and neck: Prognostic value of clear margins","volume":"116","author":"Penel","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s00066-013-0489-9","article-title":"Particle therapy for mucosal melanoma of the head and neck. A single-institution retrospective comparison of proton and carbon ion therapy","volume":"190","author":"Demizu","year":"2014","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.radonc.2015.10.025","article-title":"Phase II study of proton beam therapy as a nonsurgical approach for mucosal melanoma of the nasal cavity or para-nasal sinuses","volume":"118","author":"Zenda","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib19","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1002\/1097-0142(19840315)53:6<1299::AID-CNCR2820530613>3.0.CO;2-4","article-title":"Dimethyl triazeno imidazole carboxamide and combination therapy for melanoma. IV. Late results after complete response to chemotherapy (Central Oncology Group protocols 7130, 7131, and 7131A)","volume":"53","author":"Hill","year":"1984","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejca.2013.09.007","article-title":"Efficacy and safety of ipilimumab 3mg\/kg in patients with pretreated, metastatic, mucosal melanoma","volume":"50","author":"Del Vecchio","year":"2014","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib21","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1056\/NEJMoa1412082","article-title":"Nivolumab in previously untreated melanoma without BRAF mutation","volume":"22","author":"Robert","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature14292","article-title":"Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer","volume":"520","author":"Twyman-Saint Victor","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ijrobp.2005.07.298","article-title":"Outcomes of visual acuity in carbon ion radiotherapy: Analysis of dose-volume histograms and prognostic factors","volume":"64","author":"Hasegawa","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib24","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.ijrobp.2008.12.068","article-title":"Analysis of vision loss caused by radiation-induced optic neuropathy after particle therapy for head-and-neck and skull-base tumors adjacent to optic nerves","volume":"75","author":"Demizu","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib25","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1748-717X-9-92","article-title":"Effects of the dose-volume relationship on and risk factors for maxillary osteoradionecrosis after carbon ion radiotherapy","volume":"9","author":"Sasahara","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2016.12.028_bib26","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.tripleo.2007.10.011","article-title":"Relationship between oral health status and development of osteoradionecrosis of the mandible: A retrospective longitudinal study","volume":"105","author":"Katsura","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616336021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301616336021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T08:23:54Z","timestamp":1718958234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301616336021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0360301616336021"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.12.028","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multicenter Study of Carbon-Ion Radiation Therapy for Mucosal Melanoma of the Head and Neck: Subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) Study (1402 HN)","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2016.12.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}