{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T04:18:42Z","timestamp":1768796322190,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.ijrobp.2017.11.038","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T01:01:53Z","timestamp":1512176513000},"page":"630-638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Prospective, Multicenter, Phase 2 Trial of Induction Chemotherapy Followed by Bio-Chemoradiotherapy for Locally Advanced Recurrent Nasopharyngeal Carcinoma"],"prefix":"10.1016","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6696-3000","authenticated-orcid":false,"given":"Wai-Tong","family":"Ng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger K.C.","family":"Ngan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora L.W.","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-6471","authenticated-orcid":false,"given":"Stewart Y.","family":"Tung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3415-8901","authenticated-orcid":false,"given":"Kam-Tong","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.M.","family":"Kam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry C.K.","family":"Sze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry H.Y.","family":"Yiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy L.K.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Lung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne W.M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2017.11.038_bib1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ijrobp.2009.11.024","article-title":"Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma","volume":"79","author":"Ng","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.oraloncology.2014.01.017","article-title":"The impact of dosimetric inadequacy on treatment outcome of nasopharyngeal carcinoma with IMRT","volume":"50","author":"Ng","year":"2014","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib3","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.oraloncology.2012.02.017","article-title":"Nasopharyngeal carcinoma: Salvage of local recurrence","volume":"48","author":"Lee","year":"2012","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0360-3016(93)90491-D","article-title":"Retrospective analysis of patients with nasopharyngeal carcinoma treated during 1976-1985: Survival after local recurrence","volume":"26","author":"Lee","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib5","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0360-3016(00)00776-8","article-title":"Salvage radiation therapy for locally recurrent nasopharyngeal carcinoma","volume":"48","author":"Leung","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/COC.0b013e318277d804","article-title":"Salvage treatment for locally recurrent nasopharyngeal carcinoma (NPC)","volume":"37","author":"Chen","year":"2014","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.clon.2011.11.010","article-title":"Long-term outcomes and prognostic factors of re-irradiation for locally recurrent nasopharyngeal carcinoma using intensity-modulated radiotherapy","volume":"24","author":"Han","year":"2012","journal-title":"Clin Oncol (R\u00a0Coll Radiol)"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib8","doi-asserted-by":"crossref","first-page":"e73918","DOI":"10.1371\/journal.pone.0073918","article-title":"Effectiveness and toxicities of intensity-modulated radiotherapy for patients with locally recurrent nasopharyngeal carcinoma","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib9","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1016\/j.ejca.2012.06.016","article-title":"Long-term treatment outcome of recurrent nasopharyngeal carcinoma treated with salvage intensity modulated radiotherapy","volume":"48","author":"Hua","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib10","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1002\/cncr.28934","article-title":"Effect of total dose and fraction size on survival of patients with locally recurrent nasopharyngeal carcinoma treated with intensity-modulated radiotherapy: A phase 2, single-center, randomized controlled trial","volume":"120","author":"Tian","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib11","doi-asserted-by":"crossref","first-page":"43450","DOI":"10.18632\/oncotarget.15896","article-title":"The challenge in treating locally recurrent T3-4 nasopharyngeal carcinoma: The survival benefit and severe late toxicities of re-irradiation with intensity-modulated radiotherapy","volume":"8","author":"Tian","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib12","doi-asserted-by":"crossref","first-page":"32883","DOI":"10.1038\/srep32883","article-title":"Salvage intensity-modulated radiation therapy (IMRT) for locally recurrent nasopharyngeal cancer after definitive IMRT: A novel scenario of the modern era","volume":"6","author":"Kong","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib13","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/S1470-2045(16)30410-7","article-title":"Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: A phase 3, multicentre, randomised controlled trial","volume":"17","author":"Sun","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib14","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1093\/annonc\/mdq783","article-title":"Docetaxel, cisplatin and 5-fluorouracil-based induction chemotherapy followed by intensity-modulated radiotherapy concurrent with cisplatin in locally advanced EBV-related nasopharyngeal cancer","volume":"22","author":"Bossi","year":"2011","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib15","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa071028","article-title":"Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer","volume":"357","author":"Vermorken","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib16","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMoa070956","article-title":"Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer","volume":"357","author":"Posner","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib17","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/jnci\/djp007","article-title":"Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation","volume":"101","author":"Pointreau","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib18","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1200\/JCO.2012.42.3988","article-title":"Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: The TREMPLIN randomized phase II study","volume":"31","author":"Lefebvre","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib19","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa053422","article-title":"Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck","volume":"354","author":"Bonner","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijrobp.2003.10.038","article-title":"Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy","volume":"59","author":"Chua","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib21","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.ijrobp.2004.02.050","article-title":"C225 antiepidermal growth factor receptor antibody enhances the efficacy of docetaxel chemoradiotherapy","volume":"59","author":"Nakata","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib22","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/cncr.30520","article-title":"Tumor response to neoadjuvant chemotherapy predicts long-term survival outcomes in patients with locoregionally advanced nasopharyngeal carcinoma: A secondary analysis of a randomized phase 3 clinical trial","volume":"123","author":"Peng","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/01.coc.0000180389.86104.68","article-title":"Induction chemotherapy with cisplatin and gemcitabine followed by reirradiation for locally recurrent nasopharyngeal carcinoma","volume":"28","author":"Chua","year":"2005","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib24","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ijrobp.2006.02.010","article-title":"Concurrent weekly docetaxel and concomitant boost radiation therapy in the treatment of locally advanced squamous cell cancer of the head and neck","volume":"65","author":"Tishler","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib25","first-page":"4013","article-title":"Hyperfractionated radiotherapy with concurrent docetaxel for advanced head and neck cancer: A phase II study","volume":"32","author":"Karasawa","year":"2012","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib26","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1200\/JCO.2013.53.9163","article-title":"Postoperative chemoradiotherapy and cetuximab for high-risk squamous cell carcinoma of the head and neck: Radiation Therapy Oncology Group RTOG-0234","volume":"32","author":"Harari","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib27","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/annonc\/mdr401","article-title":"A phase II study of concurrent cetuximab-cisplatin and intensity-modulated radiotherapy in locoregionally advanced nasopharyngeal carcinoma","volume":"23","author":"Ma","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s12032-014-0170-x","article-title":"Toxicity of concurrent chemoradiotherapy with cetuximab for locoregionally advanced nasopharyngeal carcinoma","volume":"31","author":"Feng","year":"2014","journal-title":"Med Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.oraloncology.2017.02.026","article-title":"Combining cetuximab with chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma: A propensity score analysis","volume":"67","author":"Xia","year":"2017","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/CAD.0000000000000294","article-title":"Cetuximab in combination with chemoradiotherapy in the treatment of recurrent and\/or metastatic nasopharyngeal carcinoma","volume":"27","author":"Xu","year":"2016","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib31","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ijrobp.2011.07.006","article-title":"Intensity-modulated radiation therapy in the salvage of locally recurrent nasopharyngeal carcinoma","volume":"83","author":"Qiu","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.radonc.2005.10.010","article-title":"Re-irradiation of nasopharyngeal carcinoma with intensity-modulated radiotherapy","volume":"77","author":"Chua","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijrobp.2009.01.055","article-title":"Reirradiation of locally recurrent nasopharynx cancer with external beam radiotherapy with or without brachytherapy","volume":"76","author":"Koutcher","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib34","doi-asserted-by":"crossref","first-page":"E1102","DOI":"10.1002\/hed.24166","article-title":"Outcomes after reirradiation for recurrent nasopharyngeal carcinoma: North American experience","volume":"38 Suppl 1","author":"Karam","year":"2016","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib35","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/hed.24645","article-title":"Reirradiation with intensity-modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma","volume":"39","author":"Chan","year":"2017","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib36","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s00405-016-4339-0","article-title":"Hyperfractionation compared to standard fractionation in intensity-modulated radiation therapy for patients with locally advanced recurrent nasopharyngeal carcinoma","volume":"274","author":"Lee","year":"2017","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib37","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1200\/JCO.2015.60.9347","article-title":"Management of nasopharyngeal carcinoma: Current practice and future perspective","volume":"33","author":"Lee","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib38","first-page":"443","article-title":"A treatment planning comparison between proton beam therapy and intensity-modulated x-ray therapy for recurrent nasopharyngeal carcinoma","volume":"18","author":"Liu","year":"2010","journal-title":"J Xray Sci Technol"},{"key":"10.1016\/j.ijrobp.2017.11.038_bib39","doi-asserted-by":"crossref","first-page":"774","DOI":"10.7150\/jca.14399","article-title":"Phase I\/II trial evaluating carbon ion radiotherapy for salvaging treatment of locally recurrent nasopharyngeal carcinoma","volume":"7","author":"Kong","year":"2016","journal-title":"J Cancer"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301617341640?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301617341640?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T15:24:18Z","timestamp":1603466658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301617341640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0360301617341640"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2017.11.038","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prospective, Multicenter, Phase 2 Trial of Induction Chemotherapy Followed by Bio-Chemoradiotherapy for Locally Advanced Recurrent Nasopharyngeal Carcinoma","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2017.11.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}