{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:45:01Z","timestamp":1761896701218},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.ijrobp.2018.02.003","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T16:50:17Z","timestamp":1518540617000},"page":"445-452","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Implications of Pathologic Complete Response Beyond Mediastinal Nodal Clearance With High-Dose Neoadjuvant Chemoradiation Therapy in Locally Advanced, Non-Small Cell Lung Cancer"],"prefix":"10.1016","volume":"101","author":[{"given":"Melissa A.L.","family":"Vyfhuis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whitney M.","family":"Burrows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Bhooshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Suntharalingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Donahue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Feliciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahed","family":"Badiyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Edelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamus R.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Friedberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelby","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashutosh","family":"Sachdeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward M.","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Charles B.","family":"Simone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Feigenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranshu","family":"Mohindra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2018.02.003_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21387","article-title":"Cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC lung cancer staging project: Proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib3","doi-asserted-by":"crossref","first-page":"504","DOI":"10.6004\/jnccn.2017.0050","article-title":"Non-small cell lung cancer, version 5.2017, NCCN Clinical Practice Guidelines in Oncology","volume":"15","author":"Ettinger","year":"2017","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1470-2045(14)71207-0","article-title":"Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage 3 NSCLC RTOG 0617","volume":"16","author":"Bradley","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib5","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1056\/NEJMoa1709937","article-title":"Durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer","volume":"377","author":"Antonia","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib6","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1200\/JCO.2009.26.2543","article-title":"Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small cell lung cancer","volume":"28","author":"Aup\u00e9rin","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0140-6736(09)60737-6","article-title":"Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: A phase III randomised controlled trial","volume":"374","author":"Albain","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib8","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1200\/JCO.1995.13.8.1880","article-title":"Concurrent cisplatin\/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small-cell lung cancer: Mature results of Southwest Oncology Group phase II study 8805","volume":"13","author":"Albain","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ijrobp.2011.11.069","volume":"84","author":"Suntharalingam","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib10","first-page":"259","article-title":"Oncological outcomes from trimodality therapy receiving definitive doses of\u00a0neoadjuvant chemoradiation (\u226560\u2009Gy) and factors influencing consideration for surgery in stage III non-small cell lung cancer","volume":"2","author":"Vyfhuis","year":"2017","journal-title":"Adv\u00a0Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3816\/CLC.2009.n.048","article-title":"Results of trimodality therapy in patients with stage IIIA (N2-bulky) and stage IIIB non-small-cell lung cancer","volume":"10","author":"Li","year":"2009","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib12","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1245\/s10434-014-3540-x","article-title":"Pretreatment clinical mediastinal nodal bulk and extent do not influence survival in N2-positive stage IIIA non-small cell lung cancer patients treated with trimodality therapy","volume":"21","author":"Lee","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib13","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1200\/JCO.2003.11.040","article-title":"Mediastinal lymph node clearance after docetaxel-cisplatin neoadjuvant chemotherapy is prognostic of survival in patients with stage IIIA pN2 non-small-cell lung cancer: A multicenter phase II trial","volume":"21","author":"Betticher","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib14","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S1470-2045(08)70156-6","article-title":"Effect of preoperative chemoradiation in addition to preoperative chemotherapy: A randomised trial in stage III non-small-cell lung cancer","volume":"9","author":"Thomas","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.cllc.2012.10.003","article-title":"Neoadjuvant chemotherapy with docetaxel-cisplatin in patients with stage III N2 non-small-cell lung cancer","volume":"14","author":"Liao","year":"2013","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib16","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1016\/S1470-2045(13)70334-6","article-title":"Pathologic response after neoadjuvant chemotherapy in resectable non-small cell lung cancers: Proposal for the use of major pathologic response as a surrogate endpoint","volume":"15","author":"Hellman","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.lungcan.2014.06.005","article-title":"Trimodality therapy for stage IIIA non-small cell lung cancer: Benchmarking multi-disciplinary team decision-making and function","volume":"85","author":"Dickhoff","year":"2014","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib18","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1634\/theoncologist.2012-0133","article-title":"Brentuximab vedotin in transplant-naive patients with relapsed or refractory Hodgkin lymphoma: Analysis of two phase I studies","volume":"17","author":"Forero-Torres","year":"2012","journal-title":"Oncologist"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib19","doi-asserted-by":"crossref","first-page":"34388","DOI":"10.1038\/srep34388","article-title":"Neoadjuvant chemoradiotherapy vesus chemotherapy alone followed by surgery for resectable stage III non-small-cell lung cancer: A meta-analysis","volume":"6","author":"Xian Guo","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib20","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/jnci\/86.9.673","article-title":"A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer","volume":"86","author":"Roth","year":"1994","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1056\/NEJM199401203300301","article-title":"A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer","volume":"330","author":"Rosell","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib22","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1200\/JCO.1993.11.9.1757","article-title":"Pathologic complete response in advanced non-small-cell lung cancer following preoperative chemotherapy: Implications for the design of future non-small-cell lung cancer combined modality trials","volume":"11","author":"Pisters","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/COC.0b013e3181e841ce","article-title":"Outcomes after trimodality therapy for esophageal cancer: The impact of histology on failure patterns","volume":"34","author":"Koshy","year":"2011","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib24","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ijrobp.2017.07.036","article-title":"Update of a prospective study of stereotactic body radiation therapy for post-chemoradiation residual disease in stage II\/III non-small cell lung cancer","volume":"99","author":"Kumar","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2018.02.003_bib25","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1056\/NEJMoa1507643","article-title":"Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer","volume":"373","author":"Borghaei","year":"2015","journal-title":"N Engl J Med"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301618302505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301618302505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T03:35:08Z","timestamp":1535081708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301618302505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0360301618302505"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2018.02.003","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implications of Pathologic Complete Response Beyond Mediastinal Nodal Clearance With High-Dose Neoadjuvant Chemoradiation Therapy in Locally Advanced, Non-Small Cell Lung Cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2018.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}