{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:06:02Z","timestamp":1778771162197,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.ijrobp.2018.06.401","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T17:13:06Z","timestamp":1531329186000},"page":"609-618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["VEGF-Grab Enhances the Efficacy of Radiation Therapy by Blocking VEGF-A and Treatment-Induced PlGF"],"prefix":"10.1016","volume":"102","author":[{"given":"Intae","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Sung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gou Young","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Kyung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2018.06.401_bib1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJMoa1308345","article-title":"Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma","volume":"370","author":"Chinot","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11060-015-1791-4","article-title":"Hypofractionated-intensity modulated radiotherapy (hypo-IMRT) and temozolomide (TMZ) with or without bevacizumab (BEV) for newly diagnosed glioblastoma multiforme (GBM): A comparison of two prospective phase II trials","volume":"123","author":"Carlson","year":"2015","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib3","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/neuonc\/nou029","article-title":"A single-institution phase II trial of radiation, temozolomide, erlotinib, and bevacizumab for initial treatment of glioblastoma","volume":"16","author":"Clarke","year":"2014","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1200\/JCO.2009.24.8252","article-title":"Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: Efficacy and circulating angiogenic biomarkers associated with therapeutic resistance","volume":"28","author":"Kopetz","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib5","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1172\/JCI40283","article-title":"Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice","volume":"120","author":"Kioi","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib6","first-page":"442","article-title":"Molecular mechanisms involved in tumor repopulation after radiotherapy","volume":"2","author":"Ng","year":"2013","journal-title":"Transl Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib7","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/neuonc\/not082","article-title":"Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma","volume":"15","author":"Lu-Emerson","year":"2013","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib8","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ccell.2015.02.015","article-title":"Macrophages and therapeutic resistance in cancer","volume":"27","author":"Ruffell","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fphys.2013.00157","article-title":"The irradiated tumor microenvironment: Role of tumor-associated macrophages in vascular recovery","volume":"4","author":"Russell","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib10","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1073\/pnas.0911378107","article-title":"Inhibition of Mac-1 (CD11b\/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment","volume":"107","author":"Ahn","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1084\/jem.20150295","article-title":"The interaction of anticancer therapies with tumor-associated macrophages","volume":"212","author":"Mantovani","year":"2015","journal-title":"J Exp Med"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib12","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: In\u00a0vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib13","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1073\/pnas.1525360113","article-title":"Ang-2\/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival","volume":"113","author":"Kloepper","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib14","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1073\/pnas.1525349113","article-title":"Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages","volume":"113","author":"Peterson","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib16","doi-asserted-by":"crossref","first-page":"17069","DOI":"10.1073\/pnas.0708148104","article-title":"Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy","volume":"104","author":"Ebos","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib17","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1200\/JCO.2008.21.1771","article-title":"Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: A multidisciplinary phase II study","volume":"27","author":"Willett","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cell.2007.08.038","article-title":"Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels","volume":"131","author":"Fischer","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib19","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1158\/1078-0432.CCR-08-2276","article-title":"\u201cAntimyeloangiogenic\u201d therapy for cancer by inhibiting PlGF","volume":"15","author":"Loges","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ccr.2010.11.009","article-title":"HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF","volume":"19","author":"Rolny","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib21","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1158\/1078-0432.CCR-15-1839","article-title":"PlGF\/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity","volume":"22","author":"Incio","year":"2016","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib22","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1158\/1535-7163.MCT-14-0968-T","article-title":"Novel glycosylated VEGF decoy receptor fusion protein, VEGF-grab, efficiently suppresses tumor angiogenesis and progression","volume":"14","author":"Lee","year":"2015","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib23","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nrc2524","article-title":"FLT1 and its ligands VEGFB and PlGF: Drug targets for anti-angiogenic therapy?","volume":"8","author":"Fischer","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/87904","article-title":"Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions","volume":"7","author":"Carmeliet","year":"2001","journal-title":"Nature Medicine"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib25","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1038\/onc.2012.510","article-title":"The growing complexity of HIF-1\u0251's role in tumorigenesis: DNA repair and beyond","volume":"32","author":"Rohwer","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib26","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4161\/epi.27835","article-title":"Epigenetic control of hypoxia inducible factor-1\u0251-dependent expression of placental growth factor in hypoxic conditions","volume":"9","author":"Tudisco","year":"2014","journal-title":"Epigenetics"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib27","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.cell.2009.01.020","article-title":"Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization","volume":"136","author":"Mazzone","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib28","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.ccell.2016.10.018","article-title":"Normalization of tumor vessels by Tie2 activation and Ang2 inhibition enhances drug delivery and produces a favorable tumor microenvironment","volume":"30","author":"Park","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib29","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ccr.2013.09.014","article-title":"Low-dose irradiation programs macrophage differentiation to an iNOS+\/M1 phenotype that orchestrates effective T cell immunotherapy","volume":"24","author":"Klug","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib30","first-page":"553","article-title":"Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases","volume":"6","author":"Winkler","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib31","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrd3455","article-title":"Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases","volume":"10","author":"Carmeliet","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib32","doi-asserted-by":"crossref","first-page":"e69182","DOI":"10.1371\/journal.pone.0069182","article-title":"Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib33","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1158\/0008-5472.CAN-09-4446","article-title":"Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation","volume":"70","author":"Kozin","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib34","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1158\/0008-5472.CAN-12-3981","article-title":"CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer","volume":"73","author":"Xu","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.06.401_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal0225","article-title":"Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts","volume":"9","author":"Miller","year":"2017","journal-title":"Sci Transl Med"}],"updated-by":[{"DOI":"10.1016\/j.ijrobp.2018.11.027","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000}}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301618314020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301618314020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:33:43Z","timestamp":1536885223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301618314020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0360301618314020"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2018.06.401","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.ijrobp.2018.11.027","asserted-by":"object"}]},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VEGF-Grab Enhances the Efficacy of Radiation Therapy by Blocking VEGF-A and Treatment-Induced PlGF","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2018.06.401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}