{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:04:43Z","timestamp":1781103883717,"version":"3.54.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ijrobp.2018.08.024","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T23:30:19Z","timestamp":1535067019000},"page":"71-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Hypofractionated Whole-Breast Irradiation in Large-Breasted Women\u2014Is There a Dosimetric Predictor for Acute Skin Toxicities?"],"prefix":"10.1016","volume":"103","author":[{"given":"Ankur K.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane C.","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam H.","family":"Richman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin E.","family":"Champ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Saiful","family":"Huq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight E.","family":"Heron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil","family":"Beriwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2018.08.024_bib1","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","article-title":"Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10 801 women in 17 randomised trials","volume":"378","author":"Darby","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1470-2045(08)70077-9","article-title":"The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial","volume":"9","author":"Bentzen","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib3","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0140-6736(08)60348-7","article-title":"The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial","volume":"371","author":"Bentzen","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa0906260","article-title":"Long-term results of hypofractionated radiation therapy for breast cancer","volume":"362","author":"Whelan","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ijrobp.2010.04.042","article-title":"Fractionation for whole breast irradiation: An American Society for Radiation Oncology (ASTRO) evidence-based guideline","volume":"81","author":"Smith","year":"2011","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.prro.2018.01.012","article-title":"Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline","volume":"8","author":"Smith","year":"2018","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib7","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.ijrobp.2015.08.013","article-title":"Clinical pathways: A catalyst for the adoption of hypofractionation for early-stage breast cancer","volume":"93","author":"Chapman","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib8","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.ijrobp.2014.09.032","article-title":"Adoption of hypofractionated radiation therapy for breast cancer after publication of randomized trials","volume":"90","author":"Jagsi","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib9","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/jnci\/94.15.1143","article-title":"Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer","volume":"94","author":"Whelan","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijrobp.2011.05.074","article-title":"Feasibility and acute toxicity of hypofractionated radiation in large-breasted patients","volume":"83","author":"Dorn","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib11","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.ijrobp.2012.01.093","article-title":"Hypofractionated whole-breast radiation therapy: Does breast size matter?","volume":"84","author":"Hannan","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib12","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1186\/1471-2407-10-508","article-title":"Predictive factors of radiation-induced skin toxicity in breast cancer patients","volume":"10","author":"Chen","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1748-717X-9-97","article-title":"Toxicity and cosmetic outcome of hypofractionated whole-breast radiotherapy: Predictive clinical and dosimetric factors","volume":"9","author":"Ciammella","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib14","doi-asserted-by":"crossref","unstructured":"Keenan LG, Lavan N, Dunne M, et\u00a0al. Modifiable risk factors for acute skin toxicity in adjuvant breast radiotherapy: Dosimetric analysis and review of the literature. [epub ahead of print]. Med Dosim. Available at: https:\/\/doi.org\/10.1016\/j.meddos.2018.01.004. Accessed May 9 2018.","DOI":"10.1016\/j.meddos.2018.01.004"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib15","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1200\/JCO.2007.15.2488","article-title":"A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis","volume":"26","author":"Pignol","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.meddos.2006.10.003","article-title":"Determination of critical dosimetric parameters for breast radiation using forward-planned segmented fields for intensity modulation","volume":"32","author":"Stelzer","year":"2007","journal-title":"Med Dosim"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib17","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1471-2407-13-230","article-title":"Standard or hypofractionated radiotherapy in the postoperative treatment of breast cancer: A retrospective analysis of acute skin toxicity and dose inhomogeneities","volume":"13","author":"Tortorelli","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/cam4.608","article-title":"Prospective evaluation of radiation-induced skin toxicity in a race\/ethnically diverse breast cancer population","volume":"5","author":"Wright","year":"2016","journal-title":"Cancer Med"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1470-2045(09)70382-1","article-title":"Comparison of patient-reported breast, arm, and shoulder symptoms and body image after radiotherapy for early breast cancer: 5-year follow-up in the randomised Standardisation of Breast Radiotherapy (START) trials","volume":"11","author":"Hopwood","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2018.08.024_bib20","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.radonc.2016.08.021","article-title":"Ten years results of the Canadian breast intensity modulated radiation therapy (IMRT) randomized controlled trial","volume":"121","author":"Pignol","year":"2016","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301618335703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301618335703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T16:40:13Z","timestamp":1553618413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301618335703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0360301618335703"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2018.08.024","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypofractionated Whole-Breast Irradiation in Large-Breasted Women\u2014Is There a Dosimetric Predictor for Acute Skin Toxicities?","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2018.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}