{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:20:17Z","timestamp":1790965217072,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["#10275598"],"award-info":[{"award-number":["#10275598"]}]},{"name":"Collaborative Cancer Research Scheme","award":["#1002743"],"award-info":[{"award-number":["#1002743"]}]},{"name":"Australian Government Department of Health and Ageing"},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001164","name":"Australian Synchrotron","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001164","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DAAD","award":["#57339330"],"award-info":[{"award-number":["#57339330"]}]}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ijrobp.2018.11.066","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T13:17:18Z","timestamp":1544102238000},"page":"1184-1193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation"],"prefix":"10.1016","volume":"103","author":[{"given":"Pavel N.","family":"Lobachevsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Giannakandropoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Forrester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason S.","family":"Palazzolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Pollakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis S.","family":"Pateras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Gorgoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia I.","family":"Terzoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl N.","family":"Sprung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros G.","family":"Georgakilas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2018.11.066_bib1","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/cncr.21324","article-title":"The role of radiotherapy in cancer treatment: Estimating optimal utilization from a review of evidence-based clinical guidelines","volume":"104","author":"Delaney","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nrc2603","article-title":"Radiation-induced bystander signalling in cancer therapy","volume":"9","author":"Prise","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.canlet.2013.09.008","article-title":"Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects","volume":"356","author":"Sprung","year":"2015","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib4","doi-asserted-by":"crossref","first-page":"17992","DOI":"10.1073\/pnas.1008260107","article-title":"Tumors induce complex DNA damage in distant proliferative tissues in\u00a0vivo","volume":"107","author":"Redon","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib5","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1158\/0008-5472.CAN-10-4579","article-title":"Systemic DNA damage related to cancer","volume":"71","author":"Martin","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib6","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1158\/0008-5472.CAN-07-3050","article-title":"Indirect macrophage responses to ionizing radiation: Implications for genotype-dependent bystander signaling","volume":"68","author":"Coates","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3109\/09553002.2016.1154217","article-title":"The normal tissue effects of microbeam radiotherapy: What do we know, and what do we need to know to plan a human clinical trial?","volume":"92","author":"Smyth","year":"2016","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib8","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1667\/0033-7587(2003)159[0632:MECHTE]2.0.CO;2","article-title":"Murine EMT-6 carcinoma: High therapeutic efficacy of microbeam radiation therapy","volume":"159","author":"Dilmanian","year":"2003","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.nima.2005.03.062","article-title":"X-ray microbeams: Tumor therapy and central nervous system research","volume":"548","author":"Dilmanian","year":"2005","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib10","doi-asserted-by":"crossref","first-page":"6389","DOI":"10.1158\/0008-5472.CAN-17-1066","article-title":"Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses","volume":"77","author":"Ventura","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib11","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1667\/RR13720.1","article-title":"Assessment and implications of scattered microbeam and broadbeam synchrotron radiation for bystander effect studies","volume":"184","author":"Lobachevsky","year":"2015","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib12","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.4049\/jimmunol.174.10.6477","article-title":"Human lymphoid and myeloid cell development in NOD\/LtSz-scid IL2r gamma null mice engrafted with mobilized human hemopoietic stem cells","volume":"174","author":"Shultz","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1586\/1744666X.2015.1024110","article-title":"GM-CSF as a target in inflammatory\/autoimmune disease: Current evidence and future therapeutic potential","volume":"11","author":"Hamilton","year":"2015","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib14","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1182\/blood-2011-09-379214","article-title":"Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling","volume":"119","author":"Hume","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib15","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.186.10.1757","article-title":"Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor","volume":"186","author":"Kurihara","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.canlet.2014.07.030","article-title":"Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol","volume":"353","author":"Georgakilas","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib17","doi-asserted-by":"crossref","first-page":"e100547","DOI":"10.1371\/journal.pone.0100547","article-title":"An evaluation of dose equivalence between synchrotron microbeam radiation therapy and conventional broadbeam radiation using clonogenic and cell impedance assays","volume":"9","author":"Ibahim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1667\/RR0659.1","article-title":"Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells","volume":"167","author":"Gollapalle","year":"2007","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib19","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nrc2523","article-title":"GammaH2AX and cancer","volume":"8","author":"Bonner","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib20","doi-asserted-by":"crossref","first-page":"10274","DOI":"10.1093\/nar\/gks795","article-title":"Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity","volume":"40","author":"Dickey","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1269\/jrr.07123","article-title":"Formation of clustered DNA damage after high-LET irradiation: A review","volume":"49","author":"Hada","year":"2008","journal-title":"J Radiat Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.mrfmmm.2010.12.016","article-title":"Role of oxidative stress and DNA damage in human carcinogenesis","volume":"711","author":"Kryston","year":"2011","journal-title":"Mutat Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib23","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1158\/1078-0432.CCR-16-0138","article-title":"Radiotherapy for non-small cell lung cancer induces DNA damage response in both irradiated and out-of-field normal tissues","volume":"22","author":"Siva","year":"2016","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.canlet.2013.09.018","article-title":"Abscopal effects of radiation therapy: A clinical review for the radiobiologist","volume":"356","author":"Siva","year":"2015","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pharmthera.2015.06.011","article-title":"The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where","volume":"154","author":"Pateras","year":"2015","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nrd.2016.231","article-title":"Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases","volume":"16","author":"Hamilton","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib27","doi-asserted-by":"crossref","first-page":"28697","DOI":"10.18632\/oncotarget.7376","article-title":"Targeting the CCL2-CCR2 signaling axis in cancer metastasis","volume":"7","author":"Lim","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/febs.14206","article-title":"Neutrophils, G-CSF and their contribution to breast cancer metastasis","volume":"285","author":"Mouchemore","year":"2018","journal-title":"FEBS J"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib29","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1158\/0008-5472.CAN-12-3981","article-title":"CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer","volume":"73","author":"Xu","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib30","doi-asserted-by":"crossref","first-page":"e109560","DOI":"10.1371\/journal.pone.0109560","article-title":"A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer","volume":"9","author":"Siva","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib31","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm3434","article-title":"TGF\u03b2 signalling in context","volume":"13","author":"Massague","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib32","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/bjc.2013.53","article-title":"Radiation-induced non-targeted response in\u00a0vivo: Role of the TGF\u03b2-TGFBR1-COX-2 signalling pathway","volume":"108","author":"Chai","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib33","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/S1470-2045(07)70280-2","article-title":"COX-2 expression predicts prostate-cancer outcome: Analysis of data from the RTOG 92-02 trial","volume":"8","author":"Khor","year":"2007","journal-title":"Lancet. Oncol"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib34","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.immunol.16.1.137","article-title":"Regulation of immune responses by TGF-beta","volume":"16","author":"Letterio","year":"1998","journal-title":"Ann Review Immunol"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib36","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/sj.onc.1210653","article-title":"Role of TGF-beta1 and nitric oxide in the bystander response of irradiated glioma cells","volume":"27","author":"Shao","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib37","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S1535-6108(03)00135-1","article-title":"Targeting the TGF beta signaling network in human neoplasia","volume":"3","author":"Dumont","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib38","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1158\/1078-0432.CCR-17-3322","article-title":"Focal irradiation and systemic TGF\u03b2 blockade in metastatic breast cancer","volume":"24","author":"Formenti","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib39","doi-asserted-by":"crossref","first-page":"7529","DOI":"10.1038\/s41598-017-07660-4","article-title":"Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior","volume":"7","author":"Alieva","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1667\/RR14503.1","article-title":"IL-6 mediates macrophage infiltration after irradiation via up-regulation of CCL2\/CCL5 in non-small cell lung cancer","volume":"187","author":"Wang","year":"2017","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib41","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1158\/2326-6066.CIR-13-0190","article-title":"The promotion of breast cancer metastasis caused by inhibition of CSF-1R\/CSF-1 signaling is blocked by targeting the G-CSF receptor","volume":"2","author":"Swierczak","year":"2014","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib42","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/rpd\/ncl461","article-title":"A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts","volume":"122","author":"Smilenov","year":"2006","journal-title":"Radiation Prot Dosimetry"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib43","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1667\/RR3319","article-title":"Low-dose binary behavior of bystander cell killing after microbeam irradiation of a single cell with focused c(k) x rays","volume":"163","author":"Schettino","year":"2005","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib44","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.4161\/cc.6.18.4682","article-title":"Gamma-H2AX in bystander cells: Not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication","volume":"6","author":"Sokolov","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib45","doi-asserted-by":"crossref","first-page":"12445","DOI":"10.1073\/pnas.0804186105","article-title":"Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum","volume":"105","author":"Mancuso","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib46","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ijrobp.2007.09.039","article-title":"In\u00a0vivo bystander effect: Cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen","volume":"70","author":"Koturbash","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib47","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1470-2045(15)00054-6","article-title":"Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: A proof-of-principle trial","volume":"16","author":"Golden","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0284186X.2017.1346385","article-title":"Hunting for abscopal and bystander effects: Clinical exploitation of non-targeted effects induced by partial high-single-dose irradiation of the hypoxic tumour segment in oligometastatic patients","volume":"56","author":"Tubin","year":"2017","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.semcancer.2015.12.003","article-title":"Potential strategies to ameliorate risk of radiotherapy-induced second malignant neoplasms","volume":"37-38","author":"Martin","year":"2015","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.ijrobp.2018.11.066_bib50","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrc1277","article-title":"Radiation-induced bystander effects\u2014Implications for cancer","volume":"4","author":"Mothersill","year":"2004","journal-title":"Nat Rev Cancer"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301618340689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301618340689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T06:37:15Z","timestamp":1565246235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301618340689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0360301618340689"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2018.11.066","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2018.11.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}