{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:34:28Z","timestamp":1790732068980,"version":"4.1.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.ijrobp.2018.12.043","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T02:12:03Z","timestamp":1546395123000},"page":"144-148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["A Phase 1\/2 Trial of Reirradiation for Diffuse Intrinsic Pontine Glioma"],"prefix":"10.1016","volume":"104","author":[{"given":"Mark J.","family":"Amsbaugh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Thall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Frances","family":"McAleer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold C.","family":"Paulino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grosshans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumen","family":"Khatua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Ketonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiral","family":"Fontanilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"McGovern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2018.12.043_bib1","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1016\/j.ejca.2013.08.006","article-title":"Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy\u2014Results of a United Kingdom phase II trial (cns 2007 04)","volume":"49","author":"Bailey","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11060-011-0681-7","article-title":"Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma","volume":"106","author":"Chassot","year":"2012","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib3","first-page":"410","article-title":"Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: A report from the children's oncology group","volume":"13","author":"Cohen","year":"2011","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26832","article-title":"A pediatric brain tumor consortium phase II trial of capecitabine rapidly disintegrating tablets with concomitant radiation therapy in children with newly diagnosed diffuse intrinsic pontine gliomas","volume":"65","author":"Kilburn","year":"2018","journal-title":"Pediatric Blood & Cancer"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/pbc.21154","article-title":"Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral vp-16: A Children\u2019s Oncology Group phase II study","volume":"50","author":"Korones","year":"2008","journal-title":"Pediatric Blood & Cancer"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0360-3016(98)00501-X","article-title":"There is no role for hyperfractionated radiotherapy in the management of children with newly diagnosed diffuse intrinsic brainstem tumors: Results of a pediatric oncology group phase III trial comparing conventional vs. hyperfractionated radiotherapy","volume":"43","author":"Mandell","year":"1999","journal-title":"J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib7","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/pbc.24971","article-title":"Effect of time from diagnosis to start of radiotherapy on children with diffuse intrinsic pontine glioma","volume":"61","author":"Pai Panandiker","year":"2014","journal-title":"Pediatric Blood & Cancer"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib8","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1002\/cncr.26659","article-title":"A phase 2 study of pegylated interferon alpha-2b (peg-intron((r))) in children with diffuse intrinsic pontine glioma","volume":"118","author":"Warren","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.radonc.2014.01.013","article-title":"Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): A randomized controlled trial","volume":"111","author":"Zaghloul","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib10","first-page":"51","article-title":"Palliative reirradiation for progressive diffuse intrinsic pontine glioma","volume":"35","author":"Fontanilla","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.prro.2016.11.005","article-title":"Radiation and subsequent reirradiation outcomes in the treatment of diffuse intrinsic pontine glioma and a systematic review of the reirradiation literature","volume":"7","author":"Freese","year":"2017","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejca.2016.12.007","article-title":"Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG\/DIPG Working Group","volume":"73","author":"Janssens","year":"2017","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib13","doi-asserted-by":"crossref","first-page":"e26988","DOI":"10.1002\/pbc.26988","article-title":"Reirradiation in patients with diffuse intrinsic pontine gliomas: The Canadian experience","volume":"65","author":"Lassaletta","year":"2018","journal-title":"Pediatric Blood & Cancer"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib14","first-page":"305","article-title":"Results of nimotuzumab and vinorelbine, radiation and re-irradiation for diffuse pontine glioma in childhood","volume":"118","author":"Massimino","year":"2014","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib15","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/10543406.2012.676586","article-title":"Adaptive randomization to improve utility-based dose-finding with bivariate ordinal outcomes","volume":"22","author":"Thall","year":"2012","journal-title":"J Biopharm Stat"},{"key":"10.1016\/j.ijrobp.2018.12.043_bib16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/pbc.21026","article-title":"The PedsQL brain tumor module: Initial reliability and validity","volume":"49","author":"Palmer","year":"2007","journal-title":"Pediatric Blood & Cancer"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301618342251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301618342251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T16:24:31Z","timestamp":1573489471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301618342251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0360301618342251"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2018.12.043","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Phase 1\/2 Trial of Reirradiation for Diffuse Intrinsic Pontine Glioma","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2018.12.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}