{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:23:55Z","timestamp":1772133835037,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001870","name":"Foundation for Polish Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"publisher","award":["502-14-338-117"],"award-info":[{"award-number":["502-14-338-117"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"publisher","award":["502-14-338-18"],"award-info":[{"award-number":["502-14-338-18"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["redjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.ijrobp.2019.04.002","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T10:30:13Z","timestamp":1555151413000},"page":"1074-1083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Lipopolysaccharide-Binding Protein Is an Early Biomarker of Cardiac Function After Radiation Therapy for Breast Cancer"],"prefix":"10.1016","volume":"104","author":[{"given":"Justyna","family":"Chalubinska-Fendler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Graczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Piotrowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystyna","family":"Wyka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzanna","family":"Nowicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartlomiej","family":"Tomasik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Fijuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kozono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Fendler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2019.04.002_bib1","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1093\/annonc\/mdv221","article-title":"Tailoring therapies\u2014improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015","volume":"26","author":"Coates","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib2","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1093\/annonc\/mdx308","article-title":"De-escalating and escalating treatments for early-stage breast cancer: The St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017","volume":"28","author":"Curigliano","year":"2017","journal-title":"Ann Oncol"},{"issue":"suppl","key":"10.1016\/j.ijrobp.2019.04.002_bib3","doi-asserted-by":"crossref","first-page":"E398","DOI":"10.1016\/j.ijrobp.2017.06.1555","article-title":"IMRT use for the treatment of early stage breast cancer in the United States","volume":"99","author":"Halasz","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fonc.2018.00087","article-title":"Deep inspiration breath hold: Techniques and advantages for cardiac sparing during breast cancer irradiation","volume":"8","author":"Bergom","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.radonc.2017.01.008","article-title":"A cardiac contouring atlas for radiotherapy","volume":"122","author":"Duane","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib6","first-page":"CD003860","article-title":"Hypofractionated radiation therapy for early breast cancer","author":"Hickey","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3816\/CBC.2008.n.054","article-title":"Cardiac morbidity and mortality after breast conservation treatment in patients with early-stage breast cancer and preexisting cardiac disease","volume":"8","author":"Gutt","year":"2008","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib8","doi-asserted-by":"crossref","first-page":"H692","DOI":"10.1152\/ajpheart.00172.2015","article-title":"The utility of cardiac biomarkers and echocardiography for the early detection of bevacizumab- and sunitinib-mediated cardiotoxicity","volume":"309","author":"Bordun","year":"2015","journal-title":"Am J Physiol Circ Physiol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib9","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","article-title":"2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines","volume":"37","author":"Zamorano","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib10","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of ischemic heart disease in women after radiotherapy for breast cancer","volume":"368","author":"Darby","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fonc.2014.00277","article-title":"Serum biomarkers for the detection of cardiac toxicity after chemotherapy and radiation therapy in breast cancer patients","volume":"4","author":"Tian","year":"2014","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13014-015-0436-2","article-title":"Troponin T-release associates with cardiac radiation doses during adjuvant left-sided breast cancer radiotherapy","volume":"10","author":"Skytt\u00e4","year":"2015","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib13","doi-asserted-by":"crossref","first-page":"e239","DOI":"10.1016\/j.ijrobp.2011.03.058","article-title":"N-Terminal pro-B-type natriuretic peptide plasma levels as a potential biomarker for cardiac damage after radiotherapy in patients with left-sided breast cancer","volume":"82","author":"D\u2019Errico","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fonc.2015.00039","article-title":"Radiation-induced heart disease: Pathologic abnormalities and putative mechanisms","volume":"5","author":"Taunk","year":"2015","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0360-3016(00)00435-1","article-title":"TGF-\u03b21 and radiation fibrosis: A master switch and a specific therapeutic target?","volume":"47","author":"Martin","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib16","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3892\/br.2016.739","article-title":"Lipopolysaccharide-binding protein is efficient in biodosimetry during radiotherapy of lung cancer","volume":"5","author":"Chalubinska-Fendler","year":"2016","journal-title":"Biomed Rep"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-015-1236-7","article-title":"Availability and outcomes of radiotherapy in Central Poland during the 2005-2012 period - an observational study","volume":"15","author":"Chalubinska-Fendler","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib18","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative analyses of normal tissue effects in the clinic (QUANTEC): An introduction to the scientific issues","volume":"76","author":"Bentzen","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib19","first-page":"os32","article-title":"Report 62","author":"Landberg","year":"1999","journal-title":"J ICRU"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib20","article-title":"Report 83: Prescribing, recording, and reporting photon-beam intensity-modulated radiation therapy (IMRT)","volume":"10","year":"2010","journal-title":"J ICRU"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib21","author":"White"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ijcard.2017.05.007","article-title":"Evaluation of traditional and novel echocardiographic methods of cardiac diastolic dysfunction post radiotherapy in breast cancer","volume":"243","author":"Sritharan","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib23","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/ehjci\/jet284","article-title":"Echocardiographic reference ranges for normal cardiac chamber size: Results from the NORRE study","volume":"15","author":"Kou","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib24","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ijrobp.2009.09.064","article-title":"Radiation-related heart disease: Current knowledge and future prospects","volume":"76","author":"Darby","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.echo.2008.11.023","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography","volume":"22","author":"Nagueh","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib26","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.3109\/0284186X.2015.1016624","article-title":"Predicting radiation-induced valvular heart damage","volume":"54","author":"Cella","year":"2015","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib27","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1080\/0284186X.2016.1182209","article-title":"Radiation dose distribution in coronary arteries in breast cancer radiotherapy","volume":"55","author":"Nilsson","year":"2016","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.clon.2012.07.012","article-title":"Modern hypofractionation schedules for tangential whole breast irradiation decrease the fraction size-corrected dose to the heart","volume":"25","author":"Appelt","year":"2013","journal-title":"Clin Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib29","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa0906260","article-title":"Long-term results of hypofractionated radiation therapy for breast cancer","volume":"362","author":"Whelan","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib30","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S1470-2045(18)30813-1","article-title":"Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: A randomised, non-inferiority, open-label, phase 3 trial","volume":"20","author":"Wang","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib31","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1200\/JCO.2017.77.6351","article-title":"Cardiac structure injury after radiotherapy for breast cancer: Cross-sectional study with individual patient data","volume":"36","author":"Taylor","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.radonc.2017.03.012","article-title":"Risk of heart disease in relation to radiotherapy and chemotherapy with anthracyclines among 19,464 breast cancer patients in Denmark, 1977-2005","volume":"123","author":"Rehammar","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.radonc.2016.02.017","article-title":"Uncertainties in estimating heart doses from 2D-tangential breast cancer radiotherapy","volume":"119","author":"Lorenzen","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib34","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1200\/JCO.2016.69.8480","article-title":"Validation and modification of a prediction model for acute cardiac events in patients with breast cancer treated with radiotherapy based on three-dimensional dose distributions to cardiac substructures","volume":"35","author":"van den Bogaard","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib35","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1200\/JCO.2016.72.0722","article-title":"Estimating the risks of breast cancer radiotherapy: Evidence from modern radiation doses to the lungs and heart and from previous randomized trials","volume":"35","author":"Taylor","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib36","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1161\/CIRCULATIONAHA.105.548206","article-title":"Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age","volume":"113","author":"Lloyd-Jones","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib37","doi-asserted-by":"crossref","first-page":"R64","DOI":"10.1186\/bcr2901","article-title":"Cardiovascular disease competes with breast cancer as the leading cause of death for older females diagnosed with breast cancer: A retrospective cohort study","volume":"13","author":"Patnaik","year":"2011","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib38","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.crad.2014.08.010","article-title":"MRI findings of radiation-induced myocardial damage in patients with oesophageal cancer","volume":"69","author":"Umezawa","year":"2014","journal-title":"Clin Radiol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib39","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ijrobp.2006.06.007","article-title":"The utility of 18F-fluorodeoxyglucose positron emission tomography for early diagnosis of radiation-induced myocardial damage","volume":"66","author":"Jingu","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib40","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s12012-014-9286-7","article-title":"Can we predict clinical cardiotoxicity with cardiac biomarkers in patients after haematopoietic stem cell transplantation?","volume":"15","author":"Roziakova","year":"2015","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib41","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/SHK.0000000000000349","article-title":"Influence of lipopolysaccharide-binding protein on pulmonary inflammation in gram-negative pneumonia","volume":"43","author":"Taddonio","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib42","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1172\/JCI116106","article-title":"Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide: Implications for cytokine production in normal and injured lungs","volume":"90","author":"Martin","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijrobp.2019.04.002_bib43","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1038\/s41598-017-03147-4","article-title":"Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes","volume":"7","author":"Y\u00fccel","year":"2017","journal-title":"Sci Rep"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301619306200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301619306200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T18:46:34Z","timestamp":1569264394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301619306200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0360301619306200"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2019.04.002","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipopolysaccharide-Binding Protein Is an Early Biomarker of Cardiac Function After Radiation Therapy for Breast Cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2019.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}