{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:32:18Z","timestamp":1785850338688,"version":"3.56.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007210","name":"Varian Medical Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007210","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mount Vernon Marie Curie Research"},{"DOI":"10.13039\/501100000771","name":"Prostate Cancer UK","doi-asserted-by":"publisher","award":["RIA15-ST2-031"],"award-info":[{"award-number":["RIA15-ST2-031"]}],"id":[{"id":"10.13039\/501100000771","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR Manchester Biomedical Research Center"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.ijrobp.2019.09.044","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T01:54:37Z","timestamp":1570758877000},"page":"525-533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["External Beam Radiation Therapy (EBRT) and High-Dose-Rate (HDR) Brachytherapy for Intermediate and High-Risk Prostate Cancer: The Impact of EBRT Volume"],"prefix":"10.1016","volume":"106","author":[{"given":"Hannah","family":"Tharmalingam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yatman","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Alonzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Wylie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imtiaz","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Heath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Hoskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2019.09.044_bib1","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/S0022-5347(05)65177-4","article-title":"Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: High incidence of lymph node metastasis","volume":"167","author":"Heidenreich","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ijrobp.2007.04.003","article-title":"An update of the phase III trial comparing whole pelvic to prostate only radiotherapy and neoadjuvant to adjuvant total androgen suppression: Updated analysis of RTOG 94-13, with emphasis on unexpected hormone\/radiation interactions","volume":"69","author":"Lawton","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib3","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ijrobp.2016.06.2455","article-title":"Is there a role for pelvic irradiation in localized prostate adenocarcinoma? Update of the long-term survival results of the GETUG-01 Randomized Study","volume":"96","author":"Pommier","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijrobp.2007.06.054","article-title":"Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer","volume":"70","author":"Kuban","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib5","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S1470-2045(14)70040-3","article-title":"Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: Long-term results from the MRC RT01 randomised controlled trial","volume":"15","author":"Dearnaley","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib6","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1200\/JCO.2005.05.2530","article-title":"Dose-response in radiotherapy for localized prostate cancer: Results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy","volume":"24","author":"Peeters","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.radonc.2012.01.007","article-title":"Randomised trial of external beam radiotherapy alone or combined with high-dose-rate brachytherapy boost for localised prostate cancer","volume":"103","author":"Hoskin","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib8","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1200\/JCO.2000.18.15.2869","article-title":"Matched-pair analysis of conformal high\u2013dose-rate brachytherapy boost versus external-beam radiation therapy alone for locally advanced prostate cancer","volume":"18","author":"Kestin","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.brachy.2010.02.196","article-title":"Comparison of PSA relapse-free survival in patients treated with ultra-high-dose IMRT versus combination HDR brachytherapy and IMRT","volume":"9","author":"Deutsch","year":"2010","journal-title":"Brachytherapy"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/bju.12514","article-title":"Comparison of high-dose (86.4 Gy) IMRT vs combined brachytherapy plus IMRT for intermediate-risk prostate cancer","volume":"114","author":"Spratt","year":"2014","journal-title":"BJU Int"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib11","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ijrobp.2012.07.006","article-title":"Direct 2-arm comparison shows benefit of high-dose-rate brachytherapy boost vs external beam radiation therapy alone for prostate cancer","volume":"85","author":"Khor","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijrobp.2014.11.018","article-title":"Brachytherapy improves biochemical failure-free survival in low- and intermediate-risk prostate cancer compared with conventionally fractionated external beam radiation therapy: A propensity score matched analysis","volume":"91","author":"Smith","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brachy.2009.04.007","article-title":"High-dose-rate brachytherapy in combination with conformal external beam radiotherapy in the treatment of prostate cancer","volume":"9","author":"Zwahlen","year":"2010","journal-title":"Brachytherapy"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib14","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1200\/JCO.2005.06.154","article-title":"Randomized trial comparing iridium implant plus external-beam radiation therapy with external-beam radiation therapy alone in node-negative locally advanced cancer of the prostate","volume":"23","author":"Sathya","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijrobp.2017.05.013","article-title":"Long-term results of a randomized trial comparing iridium implant plus external beam radiation therapy with external beam radiation therapy alone in node-negative locally advanced cancer of the prostate","volume":"99","author":"Dayes","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ijrobp.2016.11.026","volume":"98","author":"Morris","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ctrv.2018.10.004","article-title":"Brachytherapy versus external beam radiotherapy boost for prostate cancer: Systematic review with meta-analysis of randomized trials","volume":"70","author":"Kee","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0360-3016(96)00378-1","article-title":"Nonrandomized evaluation of pelvic lymph node irradiation in localized carcinoma of the prostate","volume":"36","author":"Perez","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib19","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.ijrobp.2008.12.082","article-title":"Whole pelvic radiotherapy versus prostate only radiotherapy in the management of locally advanced or aggressive prostate adenocarcinoma","volume":"75","author":"Aizer","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib20","doi-asserted-by":"crossref","first-page":"e721","DOI":"10.1016\/j.ijrobp.2010.12.003","article-title":"Effect of whole pelvic radiotherapy for patients with locally advanced prostate cancer treated with radiotherapy and long-term androgen deprivation therapy","volume":"81","author":"Mantini","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib21","doi-asserted-by":"crossref","first-page":"e0183339","DOI":"10.1371\/journal.pone.0183339","article-title":"Intensity-modulated radiotherapy reduces gastrointestinal toxicity in pelvic radiation therapy with moderate dose","volume":"12","author":"Kwak","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/jrr\/rrw098","article-title":"A retrospective comparison of outcome and toxicity of preoperative image-guided intensity-modulated radiotherapy versus conventional pelvic radiotherapy for locally advanced rectal carcinoma","volume":"58","author":"Huang","year":"2017","journal-title":"J Radiat Res"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib23","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.ijrobp.2017.07.041","article-title":"Phase 1\/2 dose-escalation study of the use of intensity modulated radiation therapy to treat the prostate and pelvic nodes in patients with prostate cancer","volume":"99","author":"Reis Ferreira","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib24","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.clon.2007.05.002","article-title":"An atlas of the pelvic lymph node regions to aid radiotherapy target volume definition","volume":"19","author":"Taylor","year":"2007","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib25","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.ijrobp.2006.04.029","article-title":"Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus Conference","volume":"65","author":"Roach","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.eururo.2016.07.043","article-title":"Patterns of lymph node failure after dose-escalated radiotherapy: Implications for extended pelvic lymph node coverage","volume":"71","author":"Spratt","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib27","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.clon.2014.06.016","article-title":"Hormone and radiotherapy versus hormone or radiotherapy alone for non-metastatic prostate cancer: A systematic review with meta-analyses","volume":"26","author":"Schmidt-Hansen","year":"2014","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ijrobp.2019.09.044_bib28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.clon.2017.02.015","article-title":"High dose rate brachytherapy as monotherapy for localised prostate cancer: Review of\u00a0the\u00a0current status","volume":"29","author":"Tselis","year":"2017","journal-title":"Clin Oncol (R Coll Radiol)"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301619338775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301619338775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:45:06Z","timestamp":1759743906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301619338775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0360301619338775"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2019.09.044","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"External Beam Radiation Therapy (EBRT) and High-Dose-Rate (HDR) Brachytherapy for Intermediate and High-Risk Prostate Cancer: The Impact of EBRT Volume","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2019.09.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}