{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:33:38Z","timestamp":1789875218278,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["CRUK\/06\/16"],"award-info":[{"award-number":["CRUK\/06\/16"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8262\/A7253"],"award-info":[{"award-number":["C8262\/A7253"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C1491\/A9895"],"award-info":[{"award-number":["C1491\/A9895"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C1491\/A15955"],"award-info":[{"award-number":["C1491\/A15955"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["SP2312\/021"],"award-info":[{"award-number":["SP2312\/021"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C46\/A3970 C46\/A10588"],"award-info":[{"award-number":["C46\/A3970 C46\/A10588"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C33589\/A19727"],"award-info":[{"award-number":["C33589\/A19727"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cancer Research Network"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ijrobp.2020.01.003","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T14:34:41Z","timestamp":1579876481000},"page":"928-938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Derivation of Dose\/Volume Constraints for the Anorectum from Clinician- and Patient-Reported Outcomes in the CHHiP Trial of Radiation Therapy Fractionation"],"prefix":"10.1016","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0425-584X","authenticated-orcid":false,"given":"Anna","family":"Wilkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Naismith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dearnaley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Gulliford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2020.01.003_bib2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S1470-2045(16)30102-4","article-title":"Conventional versus hypofractionated high-dose intensity modulated radiation therapy for prostate cancer: 5-year outcomes of the randomized, noninferiority, phase 3 CHHiP trial","volume":"17","author":"Dearnaley","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib3","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S1470-2045(15)00280-6","article-title":"Hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate-risk localised prostate cancer: 2-year patient-reported outcomes of the randomised, non-inferiority, phase 3 CHHiP trial","volume":"16","author":"Wilkins","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S1470-2045(07)70143-2","article-title":"Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: First results from the MRC RT01 randomised controlled trial","volume":"8","author":"Dearnaley","year":"2007","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib5","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ijrobp.2009.02.025","article-title":"Dose-volume constraints to reduce rectal side effects from prostate radiotherapy: Evidence from MRC RT01 Trial ISRCTN 47772397","volume":"76","author":"Gulliford","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib6","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0360-3016(03)00665-5","article-title":"Rectal dose-volume constraints in high-dose radiotherapy of localized prostate cancer","volume":"57","author":"Fiorino","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.semradonc.2017.04.005","article-title":"Radiogenomics: Identification of genomic predictors for radiation toxicity","volume":"27","author":"Rosenstein","year":"2017","journal-title":"Sem Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib8","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrclinonc.2010.135","article-title":"Treating prostate cancer with radiotherapy","volume":"7","author":"Wilkins","year":"2010","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib9","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1016\/S1470-2045(13)70504-7","article-title":"Microbiota and radiation-induced bowel toxicity: Lessons from inflammatory bowel\u00a0disease for the radiation oncologist","volume":"15","author":"Ferreira","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0167-8140(83)80021-8","article-title":"A new isoeffect curve for change in dose per fraction","volume":"1","author":"Withers","year":"1983","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib11","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.ijrobp.2007.07.2354","article-title":"Clinical and dosimetric predictors of late rectal syndrome after 3D-CRT for localized prostate cancer: Preliminary results of a multicenter prospective study","volume":"70","author":"Fiorino","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3 Suppl","key":"10.1016\/j.ijrobp.2020.01.003_bib12","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/j.ijrobp.2009.03.078","article-title":"Radiation dose-volume effects in radiation-induced rectal injury","volume":"76","author":"Michalski","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib13","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/S0022-5347(01)63222-1","article-title":"Differences in urologist and patient assessments of health related quality of life in men with prostate cancer: Results of the CaPSURE database","volume":"159","author":"Litwin","year":"1998","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib14","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1016\/j.ijrobp.2012.01.023","article-title":"Pelvic normal tissue contouring guidelines for radiation therapy: A Radiation Therapy Oncology Group consensus panel atlas","volume":"83","author":"Gay","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.radonc.2012.03.002","article-title":"The dose-response of the anal sphincter region\u2014an analysis of data from the MRC RT01 trial","volume":"103","author":"Buettner","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.semradonc.2006.04.009","article-title":"The atlas of complication incidence: A proposal for a new standard for reporting the results of radiotherapy protocols","volume":"16","author":"Jackson","year":"2006","journal-title":"Sem Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","article-title":"Index for rating diagnostic tests","volume":"3","author":"Youden","year":"1950","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib18","doi-asserted-by":"crossref","first-page":"h2464","DOI":"10.1136\/bmj.h2464","article-title":"How to read a receiving operating operating characteristic curve","volume":"350","author":"Sedgwick","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib19","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1088\/0031-9155\/54\/21\/006","article-title":"Assessing correlations between the spatial distribution of the dose to the rectal wall and late rectal toxicity after prostate radiotherapy: An analysis of data from the MRC RT01 trial (ISRCTN 47772397)","volume":"54","author":"Buettner","year":"2009","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib20","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.ijrobp.2018.01.016","article-title":"The efficacy and safety of conventional and hypofractionated high-dose radiation therapy for prostate cancer in an elderly population: A subgroup analysis of the CHHiP trial","volume":"100","author":"Wilson","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib22","first-page":"JCO1801097","article-title":"hypofractionated radiation therapy for localized prostate cancer: An ASTRO, ASCO, and AUA evidence-based guideline","author":"Morgan","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib23","doi-asserted-by":"crossref","unstructured":"Murray J, Griffin C, Gulliford S, et\u00a0al. A randomised assessment of image guided radiotherapy within a phase 3 trial of conventional or hypofractionated high dose intensity modulated radiotherapy for prostate cancer [e-pub ahead of print]. Radiother Oncol. https:\/\/doi.org\/10.1016\/j.radonc.2019.10.017, accessed December 10, 2019.","DOI":"10.1016\/j.radonc.2019.10.017"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ijrobp.2014.11.015","article-title":"Gastrointestinal dose-histogram effects in the context of dose-volume-constrained prostate radiation therapy: Analysis of data from the RADAR prostate radiation therapy trial","volume":"91","author":"Ebert","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.radonc.2014.01.007","article-title":"Dose to the inferior rectum is strongly associated with patient reported bowel quality of life after radiation therapy for prostate cancer","volume":"110","author":"Stenmark","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-8140(02)00147-0","article-title":"Relationships between DVHs and late rectal bleeding after radiotherapy for prostate cancer: Analysis of a large group of patients pooled from three institutions","volume":"64","author":"Fiorino","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib27","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.radonc.2014.10.014","article-title":"Rectal toxicity after intensity modulated radiotherapy for prostate cancer: Which rectal dose volume constraints should we use?","volume":"113","author":"Fonteyne","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijrobp.2010.08.023","article-title":"Differences in radiation dosimetry and anorectal function testing imply that anorectal symptoms may arise from different anatomic substrates","volume":"82","author":"Smeenk","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijrobp.2018.05.013","article-title":"Predicting late fecal incontinence after radiotherapy for prostate cancer: New insights from external independent validation","volume":"102","author":"Cicchetti","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib30","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.radonc.2013.10.021","article-title":"Dose\/volume-response relations for rectal morbidity using planned and simulated motion-inclusive dose distributions","volume":"109","author":"Thor","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib31","first-page":"3","article-title":"Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: The multidisciplinary \u2018VoxTox\u2019 research programme","volume":"1","author":"Burnet","year":"2017","journal-title":"CERN Ideasq J Exp Innov"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radonc.2016.05.015","article-title":"Normal tissue complication probability (NTCP) modeling using spatial dose metrics and machine learning methods for severe acute oral mucositis resulting from head and neck radiotherapy","volume":"120","author":"Dean","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib33","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.radonc.2014.02.012","article-title":"A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity","volume":"111","author":"Barnett","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib34","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1111\/jcmm.14289","article-title":"Gut microbial dysbiosis is associated with development and progression of radiation enteritis during pelvic radiotherapy","volume":"23","author":"Wang","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ijrobp.2020.01.003_bib35","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2217\/fon-2017-0073","article-title":"Hydrogel spacers in prostate radiotherapy: A promising approach to decrease rectal toxicity","volume":"13","author":"Padmanabhan","year":"2017","journal-title":"Future Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301620300560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301620300560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:46:46Z","timestamp":1759744006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301620300560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0360301620300560"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2020.01.003","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Derivation of Dose\/Volume Constraints for the Anorectum from Clinician- and Patient-Reported Outcomes in the CHHiP Trial of Radiation Therapy Fractionation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2020.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}