{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:04:05Z","timestamp":1785315845747,"version":"3.55.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ijrobp.2020.08.036","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T10:31:36Z","timestamp":1603881096000},"page":"242-251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Adaptive Proton Therapy for Pediatric Patients: Improving the Quality of the Delivered Plan With On-Treatment MRI"],"prefix":"10.1016","volume":"109","author":[{"given":"Sahaja","family":"Acharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Quesada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Gargone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Ates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsoo","family":"Uh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Krasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Merchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-ho","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2020.08.036_bib1","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1002\/cncr.30849","article-title":"Socioeconomic factors affect the selection of proton radiation therapy for children","volume":"123","author":"Shen","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/jnci\/djs463","article-title":"Proton versus intensity-modulated radiotherapy for prostate cancer: Patterns of care and early toxicity","volume":"105","author":"Yu","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib3","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1200\/JCO.2017.74.0720","article-title":"Bayesian adaptive randomization trial of passive scattering proton therapy and intensity-modulated photon radiotherapy for locally advanced non-small-cell lung cancer","volume":"36","author":"Liao","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1001\/jamaoncol.2019.4889","article-title":"Comparative effectiveness of proton vs photon therapy as part of concurrent chemoradiotherapy for locally advanced cancer","volume":"6","author":"Baumann","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib5","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1200\/JCO.2015.62.1383","article-title":"Comparing intelligence quotient change after treatment with proton versus photon radiation therapy for pediatric brain tumors","volume":"34","author":"Kahalley","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1200\/JCO.19.01706","article-title":"Superior intellectual outcomes after proton radiotherapy compared with photon radiotherapy for pediatric medulloblastoma","volume":"38","author":"Kahalley","year":"2019","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib7","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ijrobp.2015.10.015","article-title":"Online magnetic resonance image guided adaptive radiation therapy: First clinical applications","volume":"94","author":"Acharya","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fonc.2016.00215","article-title":"The MRI-Linear Accelerator Consortium: Evidence-based clinical introduction of an innovation in radiation oncology connecting researchers, methodology, data collection, quality assurance, and technical development","volume":"6","author":"Kerkmeijer","year":"2016","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib9","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1016\/j.ijrobp.2012.10.030","article-title":"Disease control after reduced volume conformal and intensity modulated radiation therapy for childhood craniopharyngioma","volume":"85","author":"Merchant","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jmir.2018.02.054","article-title":"Clinical implementation of magnetic resonance imaging systems for simulation and planning of pediatric radiation therapy","volume":"49","author":"Hua","year":"2018","journal-title":"J Med Imaging Radiat Sci"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.adro.2017.05.006","article-title":"Two-and-a-half-year clinical experience with the world\u2019s first magnetic resonance image guided radiation therapy system","volume":"2","author":"Fischer-Valuck","year":"2017","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib12","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/neuonc\/noz068","article-title":"Association between hippocampal dose and memory in survivors of childhood or adolescent low-grade glioma: A 10-year neurocognitive longitudinal study","volume":"21","author":"Acharya","year":"2019","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib13","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3109\/0284186X.2014.957414","article-title":"Incidence and dosimetric parameters of pediatric brainstem toxicity following proton therapy","volume":"53","author":"Indelicato","year":"2014","journal-title":"Acta Oncologica"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib14","doi-asserted-by":"crossref","unstructured":"Nobre L, Zapotocky M, Ramaswamy V, et\u00a0al. Outcomes of BRAF V600E pediatric gliomas treated with targeted BRAF inhibition [e-pub ahead of print]. JCO Precis Oncol. https:\/\/doi.org\/10.1200\/PO.19.00298. Accessed June 15, 2020.","DOI":"10.1200\/PO.19.00298"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.14338\/IJPT-17-00010.1","article-title":"Intensity-modulated proton therapy adaptive planning for patients with oropharyngeal cancer","volume":"4","author":"Wu","year":"2017","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib16","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.ijrobp.2012.02.041","article-title":"Adaptive\/nonadaptive proton radiation planning and outcomes in a phase II trial for locally advanced non-small cell lung cancer","volume":"84","author":"Koay","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3109\/0284186X.2012.752860","article-title":"Degradation of target coverage due to inter-fraction motion during intensity-modulated proton therapy of prostate and elective targets","volume":"52","author":"Th\u00f6rnqvist","year":"2013","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib18","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ijrobp.2019.11.007","article-title":"Plan selection in proton therapy of locally advanced prostate cancer with simultaneous treatment of multiple targets","volume":"106","author":"Pilskog","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib19","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1002\/cam4.2100","article-title":"Using adaptive magnetic resonance image-guided radiation therapy for treatment of inoperable pancreatic cancer","volume":"8","author":"Rudra","year":"2019","journal-title":"Cancer Med"},{"key":"10.1016\/j.ijrobp.2020.08.036_bib20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.radonc.2017.11.032","article-title":"Phase I trial of stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of oligometastatic or unresectable primary malignancies of the abdomen","volume":"126","author":"Henke","year":"2018","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301620341304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301620341304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:56:15Z","timestamp":1759744575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301620341304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0360301620341304"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2020.08.036","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adaptive Proton Therapy for Pediatric Patients: Improving the Quality of the Delivered Plan With On-Treatment MRI","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2020.08.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}