{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:48:37Z","timestamp":1792050517873,"version":"4.4.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.ijrobp.2020.09.063","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T13:01:16Z","timestamp":1603803676000},"page":"932-940","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Prospective Phase 2 Study of Radiation Therapy Dose and Volume De-escalation for Elective Neck Treatment of Oropharyngeal and Laryngeal Cancer"],"prefix":"10.1016","volume":"109","author":[{"given":"David J.","family":"Sher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhat-Long","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neilayan","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathan M.","family":"Subramaniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Chorley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad M.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2020.09.063_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijrobp.2017.01.018","article-title":"Re-evaluation of ipsilateral radiation for t1-t2n0-n2b tonsil carcinoma at the princess margaret hospital in the human papillomavirus era, 25 years later","volume":"98","author":"Huang","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1097\/01.mlg.0000217543.40027.1d","article-title":"Distributions of cervical lymph node metastases in oropharyngeal carcinoma: Therapeutic implications for the n0 neck","volume":"116","author":"Lim","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.oraloncology.2005.06.019","article-title":"Is dissection of level IV absolutely necessary in elective lateral neck dissection for clinically n0 laryngeal carcinoma?","volume":"42","author":"Lim","year":"2006","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib4","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1749-4486.2008.01781.x","article-title":"Selective neck dissection for n0 and n1 oral cavity and oropharyngeal cancer: Are skip metastases a real danger?","volume":"33","author":"Lodder","year":"2008","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib5","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.oraloncology.2014.02.009","article-title":"Patterns-of-failure after helical tomotherapy-based chemoradiotherapy for head and neck cancer: Implications for ctv margin, elective nodal dose and bilateral parotid sparing","volume":"50","author":"Dandekar","year":"2014","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib6","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1093\/annonc\/mdr609","article-title":"Treatment of oropharyngeal squamous cell carcinoma with IMRT: Patterns of failure after concurrent chemoradiotherapy and sequential therapy","volume":"23","author":"Sher","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib7","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.ijrobp.2012.08.004","article-title":"Patterns of disease recurrence following treatment of oropharyngeal cancer with intensity modulated radiation therapy","volume":"85","author":"Garden","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ijrobp.2009.10.028","article-title":"Regional relapse after intensity-modulated radiotherapy for head-and-neck cancer","volume":"79","author":"Duprez","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib9","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.ijrobp.2015.12.002","article-title":"Patterns of recurrence in electively irradiated lymph node regions after definitive accelerated intensity modulated radiation therapy for head and neck squamous cell carcinoma","volume":"94","author":"van den Bosch","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib10","first-page":"171","article-title":"Reduction of the dose of radiotherapy to the elective neck in head and neck squamous cell carcinoma: A randomized clinical trial. Effect on late toxicity and tumor control","volume":"122","author":"Nevens","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.radonc.2020.01.005","article-title":"Randomized clinical trial on reduction of radiotherapy dose to the elective neck in head and neck squamous cell carcinoma: Update of the long-term tumor outcome","volume":"143","author":"Deschuymer","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib12","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.2967\/jnumed.113.136796","article-title":"Head and neck PET\/CT: Therapy response interpretation criteria (hopkins criteria)-interreader reliability, accuracy, and survival outcomes","volume":"55","author":"Marcus","year":"2014","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib13","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1200\/JCO.18.01182","article-title":"Multicenter trial of [(18)f]fluorodeoxyglucose positron emission tomography\/computed tomography staging of head and neck cancer and negative predictive value and surgical impact in the n0 neck: Results from ACRIN 6685","volume":"37","author":"Lowe","year":"2019","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/bjc.2014.553","article-title":"A phase II trial of induction chemotherapy and chemo-imrt for head and neck squamous cell cancers at risk of bilateral nodal spread: The application of a bilateral superficial lobe parotid-sparing imrt technique and treatment outcomes","volume":"112","author":"Miah","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib15","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1200\/JCO.19.01007","article-title":"Phase II trial of de-intensified chemoradiotherapy for human papillomavirus-associated oropharyngeal squamous cell carcinoma","volume":"37","author":"Chera","year":"2019","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/annonc\/mdy522","article-title":"Optima: A phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal cancer","volume":"30","author":"Seiwert","year":"2019","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(18)32779-X","article-title":"Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG oncology RTOG 1016): A randomised, multicentre, non-inferiority trial","volume":"393","author":"Gillison","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib18","author":"Yom"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib19","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/annonc\/mdw051","article-title":"Response-adapted volume de-escalation (RAVD) in locally advanced head and neck cancer","volume":"27","author":"Villaflor","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.prro.2017.02.002","article-title":"Radiation therapy for oropharyngeal squamous cell carcinoma: Executive summary of an astro evidence-based clinical practice guideline","volume":"7","author":"Sher","year":"2017","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib21","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.ijrobp.2017.12.277","article-title":"Single-arm phase 2 trial of elective nodal dose reduction for patients with locoregionally advanced squamous cell carcinoma of the head and neck","volume":"100","author":"Maguire","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.oraloncology.2018.02.021","article-title":"The risk of carotid stenosis in head and neck cancer patients after radiation therapy","volume":"80","author":"Carpenter","year":"2018","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2020.09.063_bib23","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1200\/JCO.2014.55.1937","article-title":"Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma","volume":"32","author":"Fakhry","year":"2014","journal-title":"J Clin Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301620344461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301620344461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:56:23Z","timestamp":1759744583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301620344461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0360301620344461"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2020.09.063","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prospective Phase 2 Study of Radiation Therapy Dose and Volume De-escalation for Elective Neck Treatment of Oropharyngeal and Laryngeal Cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2020.09.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}