{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:02:15Z","timestamp":1783749735152,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA006973"],"award-info":[{"award-number":["P30 CA006973"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA240811"],"award-info":[{"award-number":["R01CA240811"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21CA223403"],"award-info":[{"award-number":["R21CA223403"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37CA230341"],"award-info":[{"award-number":["R37CA230341"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR200042"],"award-info":[{"award-number":["RR200042"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ijrobp.2021.08.010","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T11:05:03Z","timestamp":1629111903000},"page":"1310-1321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research"],"prefix":"10.1016","volume":"111","author":[{"given":"Xiangkun","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Dehghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulian","family":"Iordachita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken Kang-Hsin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2021.08.010_bib0001","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.ijrobp.2008.04.025","article-title":"High-resolution, small animal radiation research platform with x-ray tomographic guidance capabilities","volume":"71","author":"Wong","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0002","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1118\/1.3533947","article-title":"Characterization of image quality and image-guidance performance of a preclinical microirradiator","volume":"38","author":"Clarkson","year":"2011","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0003","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1088\/0031-9155\/56\/8\/016","article-title":"Dosimetric characterization of an image-guided stereotactic small animal irradiator","volume":"56","author":"Pidikiti","year":"2011","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0004","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1088\/0031-9155\/56\/12\/R01","article-title":"Small animal radiotherapy research platforms","volume":"56","author":"Verhaegen","year":"2011","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0005","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1118\/1.2789498","article-title":"Design and evaluation of a variable aperture collimator for conformal radiotherapy of small animals using a microCT scanner","volume":"34","author":"Graves","year":"2007","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0006","doi-asserted-by":"crossref","first-page":"18825","DOI":"10.18632\/oncotarget.7939","article-title":"An image guided small animal stereotactic radiotherapy system","volume":"7","author":"Sha","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0007","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1667\/RR2214.1","article-title":"Localized CT-guided irradiation inhibits neurogenesis in specific regions of the adult mouse brain","volume":"175","author":"Ford","year":"2011","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0008","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1593\/tlo.12136","article-title":"An integrated method for reproducible and accurate image-guided stereotactic cranial irradiation of brain tumors using the small animal radiation research platform","volume":"5","author":"Baumann","year":"2012","journal-title":"Transl Oncol"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0009","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s11060-011-0530-8","article-title":"A radiotherapy technique to limit dose to neural progenitor cell niches without compromising tumor coverage","volume":"104","author":"Redmond","year":"2011","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0010","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ilar.49.1.103","article-title":"Noninvasive bioluminescence imaging in small animals","volume":"49","author":"Zinn","year":"2008","journal-title":"ILAR J"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0011","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.tibtech.2011.06.010","article-title":"Bioluminescence imaging: Progress and applications","volume":"29","author":"Badr","year":"2011","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0012","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.tibtech.2017.03.012","article-title":"In vivo molecular bioluminescence imaging: new tools and applications","volume":"35","author":"Mezzanotte","year":"2017","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0013","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.ijrobp.2015.11.039","article-title":"Bioluminescence tomography-guided radiation therapy for preclinical research","volume":"94","author":"Zhang","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0014","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1118\/1.4947481","article-title":"Systematic study of target localization for bioluminescence tomography guided radiation therapy","volume":"43","author":"Yu","year":"2016","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0015","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nbt1074","article-title":"Looking and listening to light: The evolution of whole-body photonic imaging","volume":"23","author":"Ntziachristos","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0016","doi-asserted-by":"crossref","first-page":"7801","DOI":"10.1364\/OE.14.007801","article-title":"In vivo mouse studies with bioluminescence tomography","volume":"14","author":"Wang","year":"2006","journal-title":"Opt Express"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0017","doi-asserted-by":"crossref","DOI":"10.1117\/1.2717898","article-title":"Three-dimensional reconstruction of in vivo bioluminescent sources based on multispectral imaging","volume":"12","author":"Kuo","year":"2007","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0018","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1364\/BOE.9.004163","article-title":"Quantitative bioluminescence tomography using spectral derivative data","volume":"9","author":"Dehghani","year":"2016","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0019","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.ijrobp.2019.11.003","article-title":"In vivo bioluminescence tomography center of mass-guided conformal irradiation","volume":"106","author":"Deng","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0020","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.ijrobp.2018.01.068","article-title":"Bioluminescence tomography guided small-animal radiation therapy and tumor response assessment","volume":"102","author":"Shi","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0021","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1002\/mp.12415","article-title":"Optical molecular imaging-guided radiation therapy part 1: integrated x-ray and bioluminescence tomography","volume":"44","author":"Shi","year":"2017","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0022","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.ijrobp.2020.06.023","article-title":"A multimodality image guided precision radiation research platform: integrating X-ray, bioluminescence, and fluorescence tomography with radiation therapy","volume":"108","author":"Shi","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0023","doi-asserted-by":"crossref","first-page":"57614","DOI":"10.1155\/IJBI\/2006\/57614","article-title":"Multispectral bioluminescence tomography: Methodology and simulation","volume":"2006","author":"Cong","year":"2006","journal-title":"Int J Biomed Imaging"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0024","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1364\/OL.31.000365","article-title":"Spectrally resolved bioluminescence optical tomography","volume":"31","author":"Dehghani","year":"2006","journal-title":"Opt Lett"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0025","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1667\/RR14423.1","article-title":"Evaluation of on- and off-line bioluminescence tomography system for focal irradiation guidance","volume":"186","author":"Zhang","year":"2016","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0026","series-title":"Biomedical optics: Principles and imaging","first-page":"83","article-title":"Radiative transfer equation and diffusion theory","author":"Wang","year":"2009"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0027","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1364\/BOE.3.002131","article-title":"Compressive sensing based reconstruction in bioluminescence tomography improves image resolution and robustness to noise","volume":"3","author":"Basevi","year":"2012","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0028","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/cnm.1162","article-title":"Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction","volume":"25","author":"Dehghani","year":"2008","journal-title":"Commun Numer Methods Eng"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0029","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1118\/1.4914860","article-title":"Systematic calibration of an integrated x-ray and optical tomography system for preclinical radiation research","volume":"42","author":"Yang","year":"2015","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0030","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","article-title":"3D Slicer as an image computing platform for the quantitative imaging network","volume":"30","author":"Fedorov","year":"2012","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0031","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijrobp.2012.12.025","article-title":"Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas","volume":"86","author":"Zeng","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0032","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13014-018-1028-8","article-title":"Half brain irradiation in a murine model of breast cancer brain metastasis: magnetic resonance imaging and histological assessments of dose-response","volume":"13","author":"Zarghami","year":"2018","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0033","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0211117","article-title":"Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma","volume":"14","author":"Gunderson","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0034","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001143","article-title":"Hematopoietic stem cell gene therapy targeting TGF\u03b2 enhances the efficacy of irradiation therapy in a preclinical glioblastoma model","volume":"9","author":"Andreou","year":"2021","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0035","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1038\/s41467-018-06288-w","article-title":"Automated quantification of bioluminescence images","volume":"9","author":"Klose","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0036","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1364\/AO.49.005654","article-title":"Generalized free-space diffuse photon transport model based on the influence analysis of a camera lens diaphragm","volume":"49","author":"Chen","year":"2010","journal-title":"Appl Opt"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0037","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1364\/JOSAA.30.002572","article-title":"Quantitative surface radiance mapping using multiview images of light-emitting turbid media","volume":"30","author":"Guggenheim","year":"2013","journal-title":"J Opt Soc Am A"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0038","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/jor.20518","article-title":"Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cells","volume":"26","author":"Zilberman","year":"2008","journal-title":"J Orthop Res"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0039","doi-asserted-by":"crossref","first-page":"12294","DOI":"10.1073\/pnas.0401137101","article-title":"Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate","volume":"101","author":"Ntziachristos","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0040","doi-asserted-by":"crossref","first-page":"18252","DOI":"10.1073\/pnas.0504628102","article-title":"Volumetric tomography of fluorescent proteins through small animals in vivo","volume":"102","author":"Zacharakis","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0041","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1088\/0031-9155\/54\/4\/005","article-title":"Image-guided small animal radiation research platform: Calibration of treatment beam alignment","volume":"54","author":"Matinfar","year":"2009","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0042","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1002\/mp.13872","article-title":"A sparse orthogonal collimator for small animal intensity-modulated radiation therapy part I: Planning system development and commissioning","volume":"46","author":"Woods","year":"2019","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0043","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1002\/mp.13870","article-title":"A sparse orthogonal collimatorfor small animal intensity-modulated radiation therapy. Part II: hardware development and commissioning","volume":"46","author":"Woods","year":"2019","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0044","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.1088\/0031-9155\/60\/14\/5681","article-title":"A framework for inverse planning of beam-on times for 3D small animal radiotherapy using interactive multi-objective optimisation","volume":"60","author":"Balvert","year":"2015","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1053\/j.semnuclmed.2007.12.001","article-title":"Tumor biology-guided radiotherapy treatment planning: gross tumor volume versus functional tumor volume","volume":"38","author":"Guha","year":"2008","journal-title":"Semin Nucl Med"},{"key":"10.1016\/j.ijrobp.2021.08.010_bib0046","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1118\/1.4935869","article-title":"Vision 20\/20: Positron emission tomography in radiation therapy planning, delivery, and monitoring","volume":"42","author":"Parodi","year":"2015","journal-title":"Med Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301621026493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301621026493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:54:48Z","timestamp":1759744488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301621026493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0360301621026493"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2021.08.010","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2021.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}