{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:08:07Z","timestamp":1765994887301,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.ijrobp.2021.08.021","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T11:04:43Z","timestamp":1629889483000},"page":"121-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Noninvasive Thalamotomy for Refractory Tremor by Frameless Radiosurgery"],"prefix":"10.1016","volume":"112","author":[{"given":"Mohamed H.","family":"Khattab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Cmelak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5115-1691","authenticated-orcid":false,"given":"Alexander D.","family":"Sherry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guozhen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hedera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenna T.","family":"Phibbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Lindsell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Neimat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin N.","family":"Kirschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2021.08.021_bib0001","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1056\/NEJMe1606517","article-title":"Treatment of medically refractory essential tremor","volume":"375","author":"Louis","year":"2016","journal-title":"N Engl J Med"},{"issue":"15 Suppl","key":"10.1016\/j.ijrobp.2021.08.021_bib0002","article-title":"Prevalence and patterns of rest, postural and action tremor in drug-na\u00efve Parkinson's disease (P2.066)","volume":"90","author":"Gupta","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0003","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/mds.20884","article-title":"Quality of life and personality in essential tremor patients","volume":"21","author":"Lorenz","year":"2006","journal-title":"Mov Disord"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0004","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1474-4422(10)70322-7","article-title":"Treatment of patients with essential tremor","volume":"10","author":"Deuschl","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0005","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1002\/mds.26712","article-title":"Unmasking levodopa resistance in Parkinson's disease","volume":"31","author":"Nonnekes","year":"2016","journal-title":"Mov Disord"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0006","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.parkreldis.2010.07.011","article-title":"Survey of medication usage patterns among essential tremor patients: Movement disorder specialists vs. general neurologists","volume":"16","author":"Diaz","year":"2010","journal-title":"Park Relat Disord"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0007","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1056\/NEJM200002173420703","article-title":"A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor","volume":"342","author":"Schuurman","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0008","first-page":"1","article-title":"Stereotactic radiosurgery for tremor: Systematic review","author":"Mart\u00ednez-Moreno","year":"2018","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0009","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1212\/WNL.0000000000002087","article-title":"A prospective single-blind study of Gamma Knife thalamotomy for tremor","volume":"85","author":"Witjas","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0010","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.radonc.2017.07.030","article-title":"Treatment of the ventral intermediate nucleus for medically refractory tremor: A cost-analysis of stereotactic radiosurgery versus deep brain stimulation","volume":"125","author":"McClelland","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0011","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1227\/NEU.0b013e3182350893","article-title":"Gamma knife thalamotomy for Parkinson disease and essential tremor: A prospective multicenter study","volume":"70","author":"Ohye","year":"2012","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0012","first-page":"e543","article-title":"Techniques for the application of stereotactic head frames based on a 25-year experience","volume":"8","author":"Safaee","year":"2016","journal-title":"Cureus"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0013","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1056\/NEJMoa1600159","article-title":"A randomized trial of focused ultrasound thalamotomy for essential tremor","volume":"375","author":"Elias","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0014","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijrobp.2007.05.097","article-title":"Quality assurance of immobilization and target localization systems for frameless stereotactic cranial and extracranial hypofractionated radiotherapy","volume":"71","author":"Solberg","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.prro.2016.08.006","article-title":"Margin of error for a frameless image guided radiosurgery system: Direct confirmation based on posttreatment MRI scans","volume":"7","author":"Luo","year":"2017","journal-title":"Pract Radiat Oncol"},{"issue":"4","key":"10.1016\/j.ijrobp.2021.08.021_bib0016","first-page":"253","article-title":"Body mass index and response to stereotactic radiosurgery in the treatment of refractory trigeminal neuralgia: A retrospective cohort study","volume":"6","author":"Khattab","year":"2020","journal-title":"J Radiosurg SBRT"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0017","series-title":"Parkinson's Disease and Movement Disorders","first-page":"271","article-title":"Clinical Rating Scale for Tremor","author":"Fahn","year":"1993"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0018","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/mds.21412","article-title":"Assessment of interrater and intrarater reliability of the Fahn-Tolosa-Marin Tremor Rating Scale in essential tremor","volume":"22","author":"Stacy","year":"2007","journal-title":"Mov Disord"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0019","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/1531-8257(200101)16:1<140::AID-MDS1025>3.0.CO;2-T","article-title":"Comparison of thalamotomy to deep brain stimulation of the thalamus in essential tremor","volume":"16","author":"Pahwa","year":"2001","journal-title":"Mov Disord"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0020","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3171\/jns.2003.98.4.0779","article-title":"Deep brain stimulation for movement disorders: Morbidity and mortality in 109 patients","volume":"98","author":"Umemura","year":"2003","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0021","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000056466","article-title":"Thalamotomy caused by cardioversion in a patient treated with deep brain stimulation","volume":"74","author":"Yamamoto","year":"2000","journal-title":"Stereotact Funct Neurosurg"},{"issue":"Suppl 1-M4","key":"10.1016\/j.ijrobp.2021.08.021_bib0022","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2174\/1876529701104010042","article-title":"Deep brain stimulation: Complications and attempts at avoiding them","volume":"4","author":"Bakay","year":"2011","journal-title":"Open Neurosurg J"},{"issue":"Suppl 1","key":"10.1016\/j.ijrobp.2021.08.021_bib0023","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.4103\/2152-7806.91612","article-title":"Pitfalls in precision stereotactic surgery","volume":"3","author":"Zrinzo","year":"2012","journal-title":"Surg Neurol Int"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0024","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/acm2.12576","article-title":"Targeting inaccuracy caused by mechanical distortion of the Leksell stereotactic frame during fixation","volume":"20","author":"Renier","year":"2019","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0025","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1120\/jacmp.v17i3.5944","article-title":"Evaluation of the stability of the stereotactic Leksell Frame G in Gamma Knife radiosurgery","volume":"17","author":"Rojas-Villabona","year":"2016","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0026","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.radonc.2009.12.030","article-title":"A clinical comparison of patient setup and intra-fraction motion using frame-based radiosurgery versus a frameless image-guided radiosurgery system for intracranial lesions","volume":"95","author":"Ramakrishna","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0027","first-page":"287","article-title":"Secondary malignancy following stereotactic radiosurgery for benign neurologic disease: A cohort study and review of the literature","volume":"6","author":"Sherry","year":"2020","journal-title":"J Radiosurg SBRT"},{"key":"10.1016\/j.ijrobp.2021.08.021_bib0028","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1212\/WNL.0000000000002546","article-title":"Radiotherapy-induced hemichorea","volume":"86","author":"Isaacs","year":"2016","journal-title":"Neurology"},{"issue":"Suppl 1","key":"10.1016\/j.ijrobp.2021.08.021_bib0029","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3171\/2018.7.GKS18752","article-title":"Pretherapeutic resting-state fMRI profiles are associated with MR signature volumes after stereotactic radiosurgical thalamotomy for essential tremor","volume":"129","author":"Tuleasca","year":"2018","journal-title":"J Neurosurg"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301621027097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301621027097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:55:14Z","timestamp":1759744514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301621027097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0360301621027097"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2021.08.021","relation":{},"ISSN":["0360-3016"],"issn-type":[{"type":"print","value":"0360-3016"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Noninvasive Thalamotomy for Refractory Tremor by Frameless Radiosurgery","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2021.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}