{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:19:24Z","timestamp":1790691564226,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.ijrobp.2021.12.154","type":"journal-article","created":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T01:05:55Z","timestamp":1640480755000},"page":"1105-1114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ten-Year Outcomes of Hypofractionated Postmastectomy Radiation Therapy of 26 Gy in 6 Fractions"],"prefix":"10.1016","volume":"112","author":[{"given":"Fabien","family":"Mignot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Quero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guillerm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethsab\u00e9e","family":"Benadon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouna","family":"Labidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Cuvier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Giacchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Lorphelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Cahen-Doidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Espie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Hennequin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2021.12.154_bib0001","doi-asserted-by":"crossref","first-page":"513\u2011520","DOI":"10.1056\/NEJMoa0906260","article-title":"Long-term results of hypofractionated radiation therapy for breast cancer","volume":"362","author":"Whelan","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0002","first-page":"331\u2011341","article-title":"The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial","volume":"9","author":"Trialists\u2019 Group","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0003","first-page":"1098\u20111107","article-title":"The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial","volume":"371","author":"Trialists\u2019 Group","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0004","doi-asserted-by":"crossref","first-page":"467\u2011471","DOI":"10.1016\/S1470-2045(06)70699-4","article-title":"Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: Long-term results of a randomised trial","volume":"7","author":"Owen","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0005","doi-asserted-by":"crossref","first-page":"458\u2011464","DOI":"10.1002\/jso.24028","article-title":"Breast reconstruction and adjuvant therapy: A systematic review of surgical outcomes","volume":"112","author":"El-Sabawi","year":"2015","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0006","doi-asserted-by":"crossref","first-page":"352\u2011360","DOI":"10.1016\/S1470-2045(18)30813-1","article-title":"Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: A randomised, non-inferiority, open-label, phase 3 trial","volume":"20","author":"Wang","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0007","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13014-020-1463-1","article-title":"Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review","volume":"15","author":"Liu","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0008","doi-asserted-by":"crossref","first-page":"1131\u20111133","DOI":"10.1016\/0360-3016(90)90216-7","article-title":"The use of a specific hypofractionated radiation therapy regimen versus classical fractionation in the treatment of breast cancer: A randomized study of 230 patients","volume":"19","author":"Baillet","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0009","doi-asserted-by":"crossref","first-page":"3\u201110","DOI":"10.1016\/j.radonc.2014.11.030","article-title":"ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer","volume":"114","author":"Offersen","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0010","doi-asserted-by":"crossref","unstructured":"Landberg T, Chavaudra J, Dobbs J, et al. ICRU Reports. Reports of the International Commission on Radiation Units and Measurements. 1999;os-32:48-51.","DOI":"10.1093\/jicru_os32.1.48"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0011","doi-asserted-by":"crossref","first-page":"2037\u20112043","DOI":"10.1200\/JCO.2016.70.7158","article-title":"Hypofractionated postmastectomy radiation therapy is safe and effective: First results from a prospective phase II trial","volume":"35","author":"Khan","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0012","doi-asserted-by":"crossref","first-page":"694\u2011700","DOI":"10.1016\/j.ijrobp.2020.03.020","article-title":"5-year update of a multi-institution, prospective phase 2 hypofractionated postmastectomy radiation therapy trial","volume":"107","author":"Poppe","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0013","doi-asserted-by":"crossref","first-page":"2570\u20112576","DOI":"10.1007\/s12032-012-0192-1","article-title":"Hypofractionation in post-mastectomy breast cancer patients: Seven-year follow-up","volume":"29","author":"Eldeeb","year":"2012","journal-title":"Med Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0014","doi-asserted-by":"crossref","first-page":"107\u2011113","DOI":"10.4103\/apjon.apjon_46_17","article-title":"A comparative study of hypofractionated and conventional radiotherapy in postmastectomy breast cancer patients","volume":"5","author":"Rastogi","year":"2018","journal-title":"Asia Pac J Oncol Nurs"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0015","first-page":"282\u2011287","article-title":"Post mastectomy adjuvant radiotherapy in breast cancer: A comparison of three hypofractionated protocols","volume":"59","author":"Shahid","year":"2009","journal-title":"J Pak Med Assoc"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0016","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1016\/j.ijrobp.2012.08.017","article-title":"Postmastectomy hypofractionated and accelerated radiation therapy with (and without) subcutaneous amifostine cytoprotection","volume":"85","author":"Koukourakis","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0017","doi-asserted-by":"crossref","first-page":"328\u2011332","DOI":"10.1159\/000449433","article-title":"A retrospective analysis of toxicity and efficacy for 2 hypofractionated irradiation schedules versus a conventional one for post-mastectomy adjuvant radiotherapy in breast cancer","volume":"11","author":"Kouloulias","year":"2016","journal-title":"Breast Care (Basel)"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0018","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13014-019-1378-x","article-title":"Conventional versus hypofractionated postmastectomy radiotherapy: A report on long-term outcomes and late toxicity","volume":"14","author":"Chitapanarux","year":"2019","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0019","doi-asserted-by":"crossref","first-page":"109\u2011118","DOI":"10.3857\/roj.2020.00129","article-title":"Late-term effects of hypofractionated chest wall and regional nodal radiotherapy with two-dimensional technique in patients with breast cancer","volume":"38","author":"Yadav","year":"2020","journal-title":"Radiat Oncol J"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0020","doi-asserted-by":"crossref","first-page":"243\u2011247","DOI":"10.1111\/1754-9485.12242","article-title":"Hypofractionated radiation treatment following mastectomy in early breast cancer: The Christchurch experience","volume":"59","author":"Ko","year":"2015","journal-title":"J Med Imaging Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0021","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12032-018-1095-6","article-title":"Hypofractionated postmastectomy radiotherapy with helical tomotherapy in patients with immediate breast reconstruction: Dosimetric results and acute\/intermediate toxicity evaluation","volume":"35","author":"Orecchia","year":"2018","journal-title":"Med Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0022","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.4103\/jcrt.JCRT_722_19","article-title":"Comparison of two hypofractionated radiotherapy schedules in locally advanced postmastectomy breast cancer patients","volume":"16","author":"Choudhary","year":"2020","journal-title":"J Can Res Ther"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0023","doi-asserted-by":"crossref","first-page":"1086\u20111094","DOI":"10.1016\/S1470-2045(13)70386-3","article-title":"The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials","volume":"14","author":"Haviland","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0024","doi-asserted-by":"crossref","first-page":"3259\u20113565","DOI":"10.1200\/JCO.2007.11.4991","article-title":"Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial","volume":"25","author":"Bartelink","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0025","doi-asserted-by":"crossref","first-page":"551\u2011559","DOI":"10.1016\/S0360-3016(97)89483-7","article-title":"Extracapsular axillary node extension in patients receiving adjuvant systemic therapy: An indication for radiotherapy?","volume":"38","author":"Fisher","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0026","doi-asserted-by":"crossref","first-page":"2086\u20112092","DOI":"10.1016\/j.ijrobp.2011.01.055","article-title":"The impact of hypofractionated whole breast radiotherapy on local relapse in patients with Grade 3 early breast cancer: A population-based cohort study","volume":"82","author":"Herbert","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0027","doi-asserted-by":"crossref","first-page":"3261\u20113272","DOI":"10.1200\/JCO.19.02750","article-title":"Ten-year results of FAST: A randomized controlled trial of 5-fraction whole-breast radiotherapy for early breast cancer","volume":"38","author":"Brunt","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0028","first-page":"1613\u20111626","article-title":"Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial","volume":"395","author":"Brunt","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0029","doi-asserted-by":"crossref","first-page":"7\u201113","DOI":"10.1016\/j.breast.2021.01.003","article-title":"Impact of radiation dose on complications among women with breast cancer who underwent breast reconstruction and post-mastectomy radiotherapy: A multi-institutional validation study","volume":"56","author":"Chung","year":"2021","journal-title":"Breast"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0030","doi-asserted-by":"crossref","first-page":"309\u2011330","DOI":"10.1007\/s10549-007-9556-1","article-title":"An overview of prognostic factors for long-term survivors of breast cancer","volume":"107","author":"Soerjomataram","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0031","doi-asserted-by":"crossref","first-page":"357\u2011362","DOI":"10.1016\/j.ejca.2005.10.021","article-title":"Prognostic value of lymphovascular invasion in women with lymph node negative invasive breast carcinoma","volume":"42","author":"Lee","year":"2006","journal-title":"Eur J Cancer"},{"issue":"8 Suppl","key":"10.1016\/j.ijrobp.2021.12.154_bib0032","first-page":"1679\u20111687","article-title":"Fifteen-year prognostic discriminants for invasive breast carcinoma: National Surgical Adjuvant Breast and Bowel Project Protocol-06","volume":"91","author":"Fisher","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2021.12.154_bib0033","doi-asserted-by":"crossref","first-page":"1331\u20111336","DOI":"10.1002\/cncr.20140","article-title":"Time-dependent effects on survival in breast carcinoma: results of 20 years of follow-up from the Swedish Two-County Study","volume":"100","author":"Warwick","year":"2004","journal-title":"Cancer"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030162103426X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030162103426X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T10:00:36Z","timestamp":1759744836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036030162103426X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S036030162103426X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2021.12.154","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ten-Year Outcomes of Hypofractionated Postmastectomy Radiation Therapy of 26 Gy in 6 Fractions","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2021.12.154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}