{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:35:16Z","timestamp":1783953316607,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.ijrobp.2022.03.021","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T17:56:01Z","timestamp":1650477361000},"page":"825-832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy"],"prefix":"10.1016","volume":"113","author":[{"given":"Angelika","family":"Terbuch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Posch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bauernhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp J.","family":"Jost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Partl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Stranzl-Lawatsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Baciarello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Fizazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Giannatempo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Verzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praful","family":"Ravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Basso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vincenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Oing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernan Javier","family":"Cutuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Peter","family":"Dieckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Gamulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Chovanec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Daniel","family":"Fankhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Heidenreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Mohamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Thibault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Gillessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2022.03.021_bib0001","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/j.1464-410X.2005.05504.x","article-title":"The changing presentation of germ cell tumours of the testis between 1983 and 2002","volume":"95","author":"Powles","year":"2005","journal-title":"BJU Int"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0002","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000329768","article-title":"Changes of stage, predictive factors and adjuvant treatment modalities in seminomatous testicular cancer from 1987 to 2007 and their impact on the status of metastasis, recurrence-free and overall survival: A single-center analysis","volume":"87","author":"Heinzelbecker","year":"2011","journal-title":"Urol Int"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0003","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.eururo.2004.01.020","article-title":"Stage II testicular seminoma: Patterns of recurrence and outcome of treatment","volume":"45","author":"Chung","year":"2004","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0004","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1159\/000488284","article-title":"Testicular germ-cell tumors: A descriptive analysis of clinical characteristics at first presentation","volume":"100","author":"Dieckmann","year":"2018","journal-title":"Urol Int"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0005","doi-asserted-by":"crossref","first-page":"33.e1","DOI":"10.1016\/j.urolonc.2012.12.002","article-title":"Changes in epidemiologic features of testicular germ cell cancer: Age at diagnosis and relative frequency of seminoma are constantly and significantly increasing","volume":"32","author":"Ruf","year":"2014","journal-title":"Urol Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0006","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/annonc\/mdy217","article-title":"ESMO consensus conference on testicular germ cell cancer: Diagnosis, treatment and follow-up","volume":"29","author":"Honecker","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0007","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.6004\/jnccn.2019.0058","article-title":"Testicular cancer, version 2.2020, NCCN clinical practice guidelines in oncology","volume":"17","author":"Gilligan","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0008","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.eururo.2015.07.044","article-title":"Guidelines on testicular cancer: 2015 update","volume":"68","author":"Albers","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0009","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(05)66984-X","article-title":"Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: A randomised trial","volume":"366","author":"Oliver","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0010","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.euf.2019.08.002","article-title":"European association of urology guidelines on testis cancer: Important take home messages","volume":"5","author":"Heidenreich","year":"2019","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0011","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0167-8140(00)00240-1","article-title":"Combination carboplatin and radiotherapy in the management of stage II testicular seminoma: Comparison with radiotherapy treatment alone","volume":"59","author":"Patterson","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0012","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/cncr.30458","article-title":"Surveillance versus adjuvant radiotherapy for patients with high-risk stage I seminoma","volume":"123","author":"Mortensen","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0013","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.clgc.2015.04.005","article-title":"Surveillance or adjuvant treatment with chemotherapy or radiotherapy in stage I seminoma: A systematic review and meta-analysis of 13 studies","volume":"13","author":"Petrelli","year":"2015","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0014","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1200\/JCO.2003.06.065","article-title":"Radiotherapy for stages IIa\/b testicular seminoma: Final report of a prospective multicenter clinical trial","volume":"21","author":"Classen","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0015","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/cam4.1317","article-title":"Risk stratification for febrile neutropenia in patients with testicular germ cell tumors","volume":"7","author":"Terbuch","year":"2018","journal-title":"Cancer Med"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0016","first-page":"594","article-title":"International germ cell cancer collaborative group","volume":"15","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0017","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1200\/JCO.20.03292","article-title":"Survival and new prognosticators in metastatic seminoma: Results from the IGCCCG-update consortium","volume":"39","author":"Beyer","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0018","series-title":"The TNM Classification of Malignant Tumors","author":"Brierley","year":"2016"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0019","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/cncr.28374","article-title":"Survival and toxicity in patients with disseminated germ cell cancer aged 40 years and older","volume":"120","author":"Thomsen","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0020","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1200\/JCO.2016.69.0958","article-title":"Outcome of men with relapse after adjuvant carboplatin for clinical stage I seminoma","volume":"35","author":"Fischer","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0021","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejca.2010.10.013","article-title":"2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours","volume":"47","author":"Aapro","year":"2011","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0022","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1289\/ehp.813959","article-title":"Radiation and chemical injury in the bone marrow","volume":"39","author":"Dritschilo","year":"1981","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0023","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2214\/ajr.157.1.1904679","article-title":"Effect of radiation therapy on thoracic and lumbar bone marrow: Evaluation with MR imaging","volume":"157","author":"Yankelevitz","year":"1991","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0024","doi-asserted-by":"crossref","first-page":"pkaa017","DOI":"10.1093\/jncics\/pkaa017","article-title":"Solid and hematologic neoplasms after testicular cancer: A US population-based study of 24 900 survivors","volume":"4","author":"Milano","year":"2020","journal-title":"JNCI Cancer Spectr"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0025","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1093\/jnci\/dji278","article-title":"Second cancers among 40,576 testicular cancer patients: Focus on long-term survivors","volume":"97","author":"Travis","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0026","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/bju.14686","article-title":"Readressing the rationale of irradiation in stage I seminoma guidelines: A critical essay","volume":"124","author":"Berghen","year":"2019","journal-title":"BJU Int"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0027","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jamaoncol.2016.3651","article-title":"Second malignant neoplasms and cause of death in patients with germ cell cancer: A Danish nationwide cohort study","volume":"2","author":"Kier","year":"2016","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0028","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1200\/JCO.2017.73.4723","article-title":"Practice makes perfect: The rest of the story in testicular cancer as a model curable neoplasm","volume":"35","author":"Tandstad","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0029","doi-asserted-by":"crossref","first-page":"80077","DOI":"10.18632\/oncotarget.11374","article-title":"Adjuvant radiation therapy in stage I seminoma: 20 years of oncologic results","volume":"7","author":"De Felice","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0030","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1200\/JCO.2005.08.003","article-title":"Randomized trial of 30 versus 20 Gy in the adjuvant treatment of stage I testicular seminoma: A report on Medical Research Council trial TE18, European Organisation for the Research and Treatment of Cancer trial 30942 (ISRCTN18525328)","volume":"23","author":"Jones","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0031","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/cncr.29983","article-title":"Intensity modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial","volume":"122","author":"Viani","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0032","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.21873\/anticanres.13753","article-title":"Age as a predictor of treatment outcome in metastatic testicular germ cell tumors","volume":"39","author":"Terbuch","year":"2019","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0033","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/ehjci\/jeaa289","article-title":"The cardiac impact of cisplatin-based chemotherapy in survivors of testicular cancer: A 30-year follow-up","volume":"22","author":"Bjerring","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0034","doi-asserted-by":"crossref","first-page":"487.e13","DOI":"10.1016\/j.urolonc.2016.06.012","article-title":"Associations between long-term serum platinum and neurotoxicity and ototoxicity, endocrine gonadal function, and cardiovascular disease in testicular cancer survivors","volume":"34","author":"Hjelle","year":"2016","journal-title":"Urol Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0035","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/cncr.32538","article-title":"Platinum exposure and cause-specific mortality among patients with testicular cancer","volume":"126","author":"Groot","year":"2020","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0036","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41585-021-00440-w","article-title":"Late adverse effects and quality of life in survivors of testicular germ cell tumour","volume":"18","author":"Chovanec","year":"2021","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0037","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/annonc\/mdt148","article-title":"Neoadjuvant carboplatin before radiotherapy in stage IIa and IIb seminoma","volume":"24","author":"Horwich","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0038","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2020.38.6_suppl.387","article-title":"The SEMITEP trial: De-escalating chemotherapy in low-volume metastatic seminoma based on early FGD-PET","volume":"38","author":"Loriot","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.03.021_bib0039","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.eururo.2013.09.004","article-title":"A risk-adapted study of cisplatin and etoposide, with or without ifosfamide, in patients with metastatic seminoma: Results of the GETUG S99 multicenter prospective study","volume":"65","author":"Fizazi","year":"2014","journal-title":"Eur Urol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301622002620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301622002620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T10:00:15Z","timestamp":1759744815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301622002620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0360301622002620"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2022.03.021","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2022.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}