{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:13:08Z","timestamp":1791573188050,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 110-004888"],"award-info":[{"award-number":["NTUH 110-004888"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2314-B-002-104"],"award-info":[{"award-number":["109-2314-B-002-104"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2314-B-002-147-MY3"],"award-info":[{"award-number":["MOST 110-2314-B-002-147-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.ijrobp.2022.06.054","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T13:09:46Z","timestamp":1654866586000},"page":"321-333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Tumor-Derived C-C Motif Ligand 2 Induces the Recruitment and Polarization of Tumor-Associated Macrophages and Increases the Metastatic Potential of Bladder Cancer Cells in the Postirradiated Microenvironment"],"prefix":"10.1016","volume":"114","author":[{"given":"Yun","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chieh","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Chieh","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Jen","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiu-Dong","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hsin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong-Shiau","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-0220","authenticated-orcid":false,"given":"Jason Chia-Hsien","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2022.06.054_bib0001","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1200\/JCO.2005.07.757","article-title":"Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer","volume":"23","author":"von der Maase","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0002","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.eururo.2014.02.038","article-title":"Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: A systematic review","volume":"66","author":"Ploussard","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0003","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1056\/NEJMoa1106106","article-title":"Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer","volume":"366","author":"James","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0004","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.eururo.2012.08.009","article-title":"ICUD-EAU International Consultation on Bladder Cancer 2012: Radical cystectomy and bladder preservation for muscle-invasive urothelial carcinoma of the bladder","volume":"63","author":"Gakis","year":"2013","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0005","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.eururo.2016.12.020","article-title":"Long-term outcomes after bladder-preserving tri-modality therapy for patients with muscle-invasive bladder cancer: An updated analysis of the massachusetts general hospital experience","volume":"71","author":"Giacalone","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0006","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s10020-018-0015-8","article-title":"Effects of radiation on the metastatic process","volume":"24","author":"Sundahl","year":"2018","journal-title":"Mol Med"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0007","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ccr.2007.11.032","article-title":"Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells","volume":"13","author":"Ahn","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0008","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1158\/1078-0432.CCR-08-1471","article-title":"Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors","volume":"15","author":"Chen","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0009","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1172\/JCI40283","article-title":"Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice","volume":"120","author":"Kioi","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0010","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20130686","article-title":"Vasculogenesis: A crucial player in the resistance of solid tumours to radiotherapy","volume":"87","author":"Brown","year":"2014","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0011","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41571-019-0238-9","article-title":"Assessing the interactions between radiotherapy and antitumour immunity","volume":"16","author":"Grassberger","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0012","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrurol.2017.172","article-title":"The anti-PD-1 era: An opportunity to enhance radiotherapy for patients with bladder cancer","volume":"15","author":"Walshaw","year":"2018","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0013","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.canlet.2018.08.025","article-title":"Tumor-associated macrophages secrete CCL2 and induce the invasive phenotype of human breast epithelial cells through upregulation of ERO1-\u03b1 and MMP-9","volume":"437","author":"Lee","year":"2018","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0014","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1158\/1078-0432.CCR-17-2687","article-title":"Identification and validation of stromal immunotype predict survival and benefit from adjuvant chemotherapy in patients with muscle-invasive bladder cancer","volume":"24","author":"Fu","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0015","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8111954","article-title":"Nuclear factor-\u03baB overexpression is correlated with poor outcomes after multimodality bladder-preserving therapy in patients with muscle-invasive bladder cancer","volume":"8","author":"Chiang","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0016","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1016\/j.bmcl.2010.10.020","article-title":"Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2","volume":"20","author":"Xue","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0017","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.bbi.2020.11.015","article-title":"Key role of CCR2-expressing macrophages in a mouse model of low back pain and radiculopathy","volume":"91","author":"Zhang","year":"2021","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0018","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.4049\/jimmunol.175.8.5370","article-title":"Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344","volume":"175","author":"Brodmerkel","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0019","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1038\/s41467-018-06152-x","article-title":"LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment","volume":"9","author":"Chen","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0020","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.addr.2017.04.010","article-title":"Progress in tumor-associated macrophage (TAM)-targeted therapeutics","volume":"114","author":"Ngambenjawong","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0021","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/sj.onc.1210909","article-title":"Radiation therapy and Toll-like receptor signaling: implications for the treatment of cancer","volume":"27","author":"Roses","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0022","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1038\/cdd.2017.91","article-title":"NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy","volume":"24","author":"Wu","year":"2017","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0023","first-page":"1069","article-title":"Macrophage content of murine sarcomas and carcinomas: associations with tumor growth parameters and tumor radiocurability","volume":"47","author":"Milas","year":"1987","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0024","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/bjc.2017.356","article-title":"TAMeless traitors: Macrophages in cancer progression and metastasis","volume":"117","author":"Aras","year":"2017","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0025","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0026","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.3892\/ol.2016.4392","article-title":"Predominance of M2-polarized macrophages in bladder cancer affects angiogenesis, tumor grade and invasiveness","volume":"11","author":"Takeuchi","year":"2016","journal-title":"Oncol Lett"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133552","article-title":"Tumor-associated macrophages provide significant prognostic information in urothelial bladder cancer","volume":"10","author":"Bostr\u00f6m","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0028","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1002\/ijc.27506","article-title":"Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells","volume":"131","author":"Maniecki","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.urolonc.2017.11.020","article-title":"M2-macrophage infiltration and macrophage traits of tumor cells in urinary bladder cancer","volume":"36","author":"Aljabery","year":"2018","journal-title":"Urol Oncol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0030","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ccr.2013.09.014","article-title":"Low-dose irradiation programs macrophage differentiation to an iNOS\u207a\/M1 phenotype that orchestrates effective T cell immunotherapy","volume":"24","author":"Klug","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0031","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fonc.2012.00089","article-title":"Irradiation promotes an m2 macrophage phenotype in tumor hypoxia","volume":"2","author":"Chiang","year":"2012","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0032","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.urology.2009.04.016","article-title":"Genetic association of monocyte chemoattractant protein 1 (MCP-1)-2518 polymorphism in Mexican patients with transitional cell carcinoma of the bladder","volume":"74","author":"V\u00e1zquez-Lavista","year":"2009","journal-title":"Urology"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0033","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cyto.2012.04.017","article-title":"Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells","volume":"59","author":"Chiu","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0034","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.canlet.2020.03.013","article-title":"Myeloid-derived suppressor cells are essential partners for immune checkpoint inhibitors in the treatment of cisplatin-resistant bladder cancer","volume":"479","author":"Takeyama","year":"2020","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0035","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1021\/acs.molpharmaceut.8b00237","article-title":"Modulating macrophage polarization through CCR2 inhibition and multivalent engagement","volume":"15","author":"Deci","year":"2018","journal-title":"Mol Pharm"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0036","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12943-020-01165-x","article-title":"CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis","volume":"19","author":"Yang","year":"2020","journal-title":"Mol Cancer"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0037","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1158\/1078-0432.CCR-13-0525","article-title":"Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: A role for targeting the CCL2\/CCR2 axis","volume":"19","author":"Sanford","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0038","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1038\/s41388-019-0772-z","article-title":"Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression","volume":"38","author":"Bao","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0039","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10138","article-title":"CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis","volume":"475","author":"Qian","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0040","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1158\/1078-0432.CCR-16-0870","article-title":"Tumor-derived CCL2 mediates resistance to radiotherapy in pancreatic ductal adenocarcinoma","volume":"23","author":"Kalbasi","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0041","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/s41419-019-2170-4","article-title":"BRD4 promotes tumor progression and NF-\u03baB\/CCL2-dependent tumor-associated macrophage recruitment in GIST","volume":"10","author":"Mu","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0042","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S1470-2045(16)00078-4","article-title":"Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: A single-centre, open-label, dose-finding, non-randomised, phase 1b trial","volume":"17","author":"Nywening","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0043","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/MOU.0000000000000740","article-title":"Current status and future directions of the use of novel immunotherapeutic agents in bladder cancer","volume":"30","author":"Lenfant","year":"2020","journal-title":"Curr Opin Urol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0044","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1200\/JCO.18.02257","article-title":"Immunotherapy for urothelial cancer: Where Are the randomized trials?","volume":"37","author":"Vera-Badillo","year":"2019","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0045","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/S0140-6736(16)00561-4","article-title":"Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial","volume":"387","author":"Rosenberg","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0046","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1056\/NEJMoa1613683","article-title":"Pembrolizumab as second-line therapy for advanced urothelial carcinoma","volume":"376","author":"Bellmunt","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0047","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1470-2045(17)30900-2","article-title":"Avelumab in metastatic urothelial carcinoma after platinum failure (JAVELIN Solid Tumor): Pooled results from two expansion cohorts of an open-label, phase 1 trial","volume":"19","author":"Patel","year":"2018","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0048","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41419-019-1906-5","article-title":"A positive feedback loop of \u03b2-catenin\/CCR2 axis promotes regorafenib resistance in colorectal cancer","volume":"10","author":"Ou","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ijrobp.2022.06.054_bib0049","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1007\/s00018-016-2210-5","article-title":"Effects of radiation on metastasis and tumor cell migration","volume":"73","author":"Vilalta","year":"2016","journal-title":"Cell Mol Life Sci"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301622005983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301622005983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:22:04Z","timestamp":1778502124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301622005983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0360301622005983"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2022.06.054","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor-Derived C-C Motif Ligand 2 Induces the Recruitment and Polarization of Tumor-Associated Macrophages and Increases the Metastatic Potential of Bladder Cancer Cells in the Postirradiated Microenvironment","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2022.06.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}