{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:33:39Z","timestamp":1775626419571,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"am","delay-in-days":347,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.ijrobp.2022.11.009","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T16:09:02Z","timestamp":1669046942000},"page":"1217-1228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-treatment DNA Methylation From Peripheral Blood"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8459-009X","authenticated-orcid":false,"given":"David C.","family":"Qian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan C.","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen N.","family":"Conneely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah W.","family":"Bruner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald C.","family":"Eldridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evanthia C.","family":"Wommack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin A.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong M.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil F.","family":"Saba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia K.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Burtness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry S.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Stokes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J.","family":"Beitler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canhua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2022.11.009_bib0001","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1056\/NEJMra1715715","article-title":"Head and neck cancer","volume":"382","author":"Chow","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0002","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.3390\/cancers13102457","article-title":"Opportunities and limits in salvage surgery in persistent or recurrent head and neck squamous cell carcinoma","volume":"13","author":"Huber","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0003","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/bjc.2013.640","article-title":"Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer","volume":"110","author":"Balermpas","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0004","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ijc.29683","article-title":"CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG)","volume":"138","author":"Balermpas","year":"2016","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0005","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nrc2344","article-title":"Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability","volume":"8","author":"Bristow","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0006","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ejca.2021.01.039","article-title":"Lost in application: Measuring hypoxia for radiotherapy optimisation","volume":"148","author":"Thiruthaneeswaran","year":"2021","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0007","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.3390\/cancers13235959","article-title":"Hypoxia and its influence on radiotherapy response of HPV-positive and HPV-negative head and neck cancer","volume":"13","author":"Wegge","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0008","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0167-8140(97)00220-X","article-title":"A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85","volume":"46","author":"Overgaard","year":"1998","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0009","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1200\/JCO.2009.27.4449","article-title":"Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): A phase III trial of the Trans-Tasman Radiation Oncology Group","volume":"28","author":"Rischin","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0010","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/cac2.12100","article-title":"Clinical utility of Epstein-Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma","volume":"40","author":"Tan","year":"2020","journal-title":"Cancer Commun"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0011","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1200\/JCO.19.02444","article-title":"Plasma circulating tumor HPV DNA for the surveillance of cancer recurrence in HPV-associated oropharyngeal cancer","volume":"38","author":"Chera","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0012","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41575-019-0230-y","article-title":"Epigenetics of colorectal cancer: Biomarker and therapeutic potential","volume":"17","author":"Jung","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0244101","article-title":"DNA methylation biomarkers in peripheral blood of patients with head and neck squamous cell carcinomas. A systematic review","volume":"15","author":"Danstrup","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0014","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijrobp.2021.04.002","article-title":"Association of epigenetic age acceleration with risk factors, survival, and quality of life in patients with head and neck cancer","volume":"111","author":"Xiao","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0015","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/bioinformatics\/btw691","article-title":"Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi","volume":"33","author":"Fortin","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0016","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4161\/epi.23470","article-title":"Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray","volume":"8","author":"Chen","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0017","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s13059-014-0503-2","article-title":"Functional normalization of 450k methylation array data improves replication in large cancer studies","volume":"15","author":"Fortin","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0018","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/bioinformatics\/bty778","article-title":"Differential methylation values in differential methylation analysis","volume":"35","author":"Xie","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0019","unstructured":"Illumina. Available at: https:\/\/support.illumina.com\/downloads\/infinium-methylationepic-v1-0-product-files.html. Accessed May 13, 2022."},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0020","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J Roy Statist Soc"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0021","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13059-019-1716-1","article-title":"A practical guide to methods controlling false discoveries in computational biology","volume":"20","author":"Korthauer","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0022","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nmeth.3885","article-title":"Data-driven hypothesis weighting increases detection power in genome-scale multiple testing","volume":"13","author":"Ignatiadis","year":"2016","journal-title":"Nat Methods"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0023","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0024","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.ijrobp.2017.02.022","article-title":"The older adult with locoregionally advanced head and neck squamous cell carcinoma: Knowledge gaps and future direction in assessment and treatment","volume":"98","author":"Maggiore","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0025","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/lary.25877","article-title":"Prognostic value of albumin in patients with head and neck cancer","volume":"126","author":"Danan","year":"2016","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0026","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/cncr.29100","article-title":"Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status","volume":"121","author":"Huang","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0027","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.critrevonc.2013.03.010","article-title":"The systemic inflammation-based neutrophil-lymphocyte ratio: Experience in patients with cancer","volume":"88","author":"Guthrie","year":"2013","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0028","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hed.20223","article-title":"Hypoxia in head and neck cancer: How much, how important?","volume":"27","author":"Janssen","year":"2005","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0029","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1068592","article-title":"Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch","volume":"295","author":"Lando","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0030","doi-asserted-by":"crossref","first-page":"32631","DOI":"10.1074\/jbc.274.46.32631","article-title":"p42\/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1","volume":"274","author":"Richard","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0031","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.bbrc.2009.12.011","article-title":"DNA methylation-dependent suppression of HIF1A in an immature hematopoietic cell line HMC-1","volume":"391","author":"Walczak-Drzewiecka","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0032","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.bbagrm.2015.10.018","article-title":"Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso","volume":"1849","author":"Pierre","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0033","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/onc.2010.481","article-title":"Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1alpha","volume":"30","author":"Koslowski","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0034","doi-asserted-by":"crossref","first-page":"50781","DOI":"10.18632\/oncotarget.9549","article-title":"Current relevance of hypoxia in head and neck cancer","volume":"7","author":"Bredell","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0035","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2407-11-35","article-title":"O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: Systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction","volume":"11","author":"Brell","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0036","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13046-020-01616-9","article-title":"Hypoxia-induced alternative splicing: The 11th hallmark of cancer","volume":"39","author":"Farina","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0037","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1242\/jcs.016410","article-title":"Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors","volume":"121","author":"Nowak","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0038","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1038\/s41467-021-24498-7","article-title":"Targeting KRAS4A splicing through the RBM39\/DCAF15 pathway inhibits cancer stem cells","volume":"12","author":"Chen","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0039","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1158\/0008-5472.CAN-17-2727","article-title":"Oncogenic ras isoforms signaling specificity at the membrane","volume":"78","author":"Nussinov","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/19336918.2018.1491234","article-title":"Role of glycosylation in hypoxia-driven cell migration and invasion","volume":"13","author":"Arriagada","year":"2019","journal-title":"Cell Adh Migr"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0041","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.chembiol.2018.02.005","article-title":"Unmasking fucosylation: From cell adhesion to immune system regulation and diseases","volume":"25","author":"Li","year":"2018","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0042","first-page":"123","article-title":"Altered mRNA expression of fucosyltransferases and fucosidase predicts prognosis in human oral carcinoma","volume":"10","author":"Mehta","year":"2021","journal-title":"Int J Mol Cell Med"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0043","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1515\/hsz-2018-0121","article-title":"Hypoxia and serum deprivation induces glycan alterations in triple negative breast cancer cells","volume":"399","author":"Albuquerque","year":"2018","journal-title":"Biol Chem"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0044","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001849","article-title":"Galectin-9 expression defines exhausted T cells and impaired cytotoxic NK cells in patients with virus-associated solid tumors","volume":"8","author":"Okoye","year":"2020","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0045","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1200\/JCO.2015.61.1509","article-title":"Immunology and immunotherapy of head and neck cancer","volume":"33","author":"Ferris","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0046","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S1470-2045(21)00347-8","article-title":"Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): A cohort-based pooled analysis","volume":"22","author":"Scott","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0047","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1158\/1078-0432.CCR-19-0211","article-title":"Rapid clearance profile of plasma circulating tumor HPV type 16 DNA during chemoradiotherapy correlates with disease control in HPV-associated oropharyngeal cancer","volume":"25","author":"Chera","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2022.11.009_bib0048","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.radonc.2015.11.027","article-title":"Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma","volume":"118","author":"Tawk","year":"2016","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301622035210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301622035210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T10:05:59Z","timestamp":1759745159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301622035210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0360301622035210"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2022.11.009","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-treatment DNA Methylation From Peripheral Blood","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2022.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}