{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:36:23Z","timestamp":1788777383091,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["11350 \/ 2017-2"],"award-info":[{"award-number":["11350 \/ 2017-2"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014252","name":"International Association for Bear Research and Management","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004830","name":"Siemens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004830","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ijrobp.2023.04.034","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T21:30:16Z","timestamp":1683322216000},"page":"750-762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prediction of Radiation-Induced Parotid Gland-Related Xerostomia in Patients With Head and Neck Cancer: Regeneration-Weighted Dose"],"prefix":"10.1016","volume":"117","author":[{"given":"Maria I.","family":"van Rijn-Dekker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"van Luijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewoud","family":"Schuit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen","family":"van der Schaaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Langendijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel J.H.M.","family":"Steenbakkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2023.04.034_bib0001","first-page":"1","article-title":"Epidemiological trends of head and neck cancer: A population-based study","volume":"2021","author":"Guo","year":"2021","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0002","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ijrobp.2007.04.021","article-title":"Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer","volume":"69","author":"Jellema","year":"2007","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0003","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1200\/JCO.2007.14.6647","article-title":"Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy","volume":"26","author":"Langendijk","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0004","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ijrobp.2012.08.030","article-title":"Toxicities affecting quality of life after chemo-IMRT of oropharyngeal cancer: Prospective study of patient-reported, observer-rated, and objective outcomes","volume":"85","author":"Hunter","year":"2013","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0005","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.semradonc.2017.08.002","article-title":"Organ-sparing in radiotherapy for head-and-neck cancer: Improving quality of life","volume":"28","author":"Hawkins","year":"2018","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0006","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ijrobp.2021.05.114","article-title":"Patient-reported toxicity and quality-of-life profiles in patients with head and neck cancer treated with definitive radiation therapy or chemoradiation","volume":"111","author":"Van den Bosch","year":"2021","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0007","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1470-2045(06)70580-0","article-title":"Oral complications of radiotherapy","volume":"7","author":"Sciubba","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0008","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.radonc.2021.01.024","article-title":"Comprehensive toxicity risk profiling in radiation therapy for head and neck cancer: A new concept for individually optimised treatment","volume":"157","author":"Van den Bosch","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0009","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative analyses of normal tissue effects in the clinic (QUANTEC): An introduction to the scientific issues","volume":"76","author":"Bentzen","year":"2010","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0010","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0360-3016(01)01512-7","article-title":"Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer","volume":"50","author":"Eisbruch","year":"2001","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0011","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): A phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0012","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.radonc.2012.03.004","article-title":"NTCP models for patient-rated xerostomia and sticky saliva after treatment with intensity modulated radiotherapy for head and neck cancer: The role of dosimetric and clinical factors","volume":"105","author":"Beetz","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0013","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1080\/0284186X.2017.1324209","article-title":"Parotid gland mean dose as a xerostomia predictor in low-dose domains","volume":"56","author":"Gabry\u015b","year":"2017","journal-title":"Acta Oncol (Madr)"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0014","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nrclinonc.2009.143","article-title":"IMRT reduces xerostomia and potentially improves QoL","volume":"6","author":"Eisbruch","year":"2009","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0015","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3109\/0284186X.2013.831186","article-title":"The QUANTEC criteria for parotid gland dose and their efficacy to prevent moderate to severe patient-rated xerostomia","volume":"53","author":"Beetz","year":"2014","journal-title":"Acta Oncol (Madr)"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0016","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.ijrobp.2004.12.035","article-title":"Volume effects and region-dependent radiosensitivity of the parotid gland","volume":"62","author":"Konings","year":"2005","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0017","doi-asserted-by":"crossref","first-page":"305ra147","DOI":"10.1126\/scitranslmed.aac4441","article-title":"Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer","volume":"7","author":"van Luijk","year":"2015","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.ijrobp.2023.04.034_bib0018","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ijrobp.2021.09.023","article-title":"Parotid gland stem cell sparing radiation therapy for patients with head and neck cancer: a double-blind randomized controlled trial","volume":"112","author":"Steenbakkers","year":"2022","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0019","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/hed.26556","article-title":"Parotid gland stem cells: Mini yet mighty","volume":"43","author":"Sari","year":"2021","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0020","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.radonc.2022.05.001","article-title":"Prospective assessment of sparing the parotid ducts via MRI sialography for reducing patient reported xerostomia","volume":"172","author":"Fried","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0021","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1634\/stemcells.2007-1034","article-title":"Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem\/progenitor pool","volume":"26","author":"Lombaert","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2022.07.006","article-title":"Impact on xerostomia for nasopharyngeal carcinoma patients treated with superficial parotid lobe-sparing intensity-modulated radiation therapy (SPLS-IMRT): A prospective phase II randomized controlled study","volume":"175","author":"Huang","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0023","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.devcel.2015.02.013","article-title":"Salivary gland homeostasis is maintained through acinar cell self-duplication","volume":"33","author":"Aure","year":"2015","journal-title":"Dev Cell"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0024","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.celrep.2018.07.016","article-title":"Limited regeneration of adult salivary glands after severe injury involves cellular plasticity","volume":"24","author":"Weng","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0025","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijrobp.2011.09.004","article-title":"Reducing xerostomia after chemo-IMRT for head-and-neck cancer: Beyond sparing the parotid glands","volume":"83","author":"Little","year":"2012","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0026","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.radonc.2017.08.002","article-title":"Sparing all salivary glands with IMRT for head and neck cancer: Longitudinal study of patient-reported xerostomia and head-and-neck quality of life","volume":"126","author":"Hawkins","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0027","doi-asserted-by":"crossref","first-page":"13165","DOI":"10.1038\/srep13165","article-title":"Patient- and therapy-related factors associated with the incidence of xerostomia in nasopharyngeal carcinoma patients receiving parotid-sparing helical tomotherapy","volume":"5","author":"Lee","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0028","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/S0959-8049(00)00186-6","article-title":"A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients","volume":"36","author":"Bjordal","year":"2000","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0029","unstructured":"US Department of Health and Human Services, National Institutes of Health, National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE), version 4.03. 2010. Available at:https:\/\/evs.nci.nih.gov\/ftp1\/CTCAE\/CTCAE_4.03\/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf. Accessed August 30, 2022."},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.radonc.2012.06.004","article-title":"Xerostomia: A day and night difference","volume":"104","author":"Dijkema","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0031","doi-asserted-by":"crossref","first-page":"W1","DOI":"10.7326\/M14-0698","article-title":"Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD): Explanation and elaboration","volume":"162","author":"Moons","year":"2015","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0032","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.radonc.2022.03.009","article-title":"Impact of sarcopenia on acute radiation-induced toxicity in head and neck cancer patients","volume":"170","author":"Karavolia","year":"2022","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ijrobp.2023.04.034_bib0033","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.radonc.2011.08.009","article-title":"Predictive modelling for swallowing dysfunction after primary (chemo)radiation: Results of a prospective observational study","volume":"105","author":"Christianen","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0034","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.radonc.2013.10.010","article-title":"Delineation of the neck node levels for head and neck tumors: A 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines","volume":"110","author":"Gr\u00e9goire","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.radonc.2015.07.041","article-title":"CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines","volume":"117","author":"Brouwer","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0036","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.radonc.2010.05.004","article-title":"The Groningen Radiotherapy-Induced Xerostomia Questionnaire: Development and validation of a new questionnaire","volume":"97","author":"Beetz","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0037","doi-asserted-by":"crossref","DOI":"10.21037\/atm.2017.02.02","article-title":"Understanding mechanisms yields novel approaches to reduce radiotherapy-related xerostomia","volume":"5","author":"van Luijk","year":"2017","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v045.i03","article-title":"mice\u00a0: Multivariate imputation by chained equations in R","volume":"45","author":"Buuren","year":"2011","journal-title":"J Stat Softw"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0039","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.radonc.2020.04.012","article-title":"Key challenges in normal tissue complication probability model development and validation: Towards a comprehensive strategy","volume":"148","author":"Van den Bosch","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0040","series-title":"Multiple Imputation for Nonresponse in Surveys","author":"Rubin","year":"1987"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0041","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/sim.6787","article-title":"Sample size considerations for the external validation of a multivariable prognostic model: A resampling study","volume":"35","author":"Collins","year":"2016","journal-title":"Stat Med"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0042","doi-asserted-by":"crossref","first-page":"m441","DOI":"10.1136\/bmj.m441","article-title":"Calculating the sample size required for developing a clinical prediction model","author":"Riley","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0043","doi-asserted-by":"crossref","first-page":"e89700","DOI":"10.1371\/journal.pone.0089700","article-title":"Using multivariate regression model with least absolute shrinkage and selection operator (LASSO) to predict the incidence of xerostomia after intensity-modulated radiotherapy for head and neck cancer","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0044","doi-asserted-by":"crossref","first-page":"18645","DOI":"10.18632\/aging.203308","article-title":"A nomogram for predicting late radiation-induced xerostomia among locoregionally advanced nasopharyngeal carcinoma in intensity modulated radiation therapy era","volume":"13","author":"Yang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0045","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.radonc.2021.03.036","article-title":"Intensity-modulated proton therapy for oropharyngeal cancer reduces rates of late xerostomia","volume":"160","author":"Cao","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0046","doi-asserted-by":"crossref","first-page":"i69","DOI":"10.1093\/jrr\/rrw047","article-title":"IMRT for head and neck cancer: Reducing xerostomia and dysphagia","volume":"57","author":"Wang","year":"2016","journal-title":"J Radiat Res"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0047","first-page":"12","article-title":"The Xerostomia Inventory: A multi-item approach to measuring dry mouth","volume":"16","author":"Thomson","year":"1999","journal-title":"Community Dent Health"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0048","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.forsciint.2004.10.026","article-title":"Review: The physiology of saliva and transfer of drugs into saliva","volume":"150","author":"Aps","year":"2005","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0049","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ijrobp.2005.06.042","article-title":"Secondary radiation damage as the main cause for unexpected volume effects: A histopathologic study of the parotid gland","volume":"64","author":"Konings","year":"2006","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0050","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.radonc.2012.02.006","article-title":"Novel approaches to improve the therapeutic index of head and neck radiotherapy: An analysis of data from the PARSPORT randomised phase III trial","volume":"103","author":"Buettner","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0051","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.radonc.2007.07.009","article-title":"Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: A dose-effect relationship","volume":"85","author":"Levendag","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0052","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.radonc.2020.09.034","article-title":"The tubarial salivary glands: A potential new organ at risk for radiotherapy","volume":"154","author":"Valstar","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0053","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1038\/s41598-019-40228-y","article-title":"Dose\/volume histogram patterns in salivary gland subvolumes influence xerostomia injury and recovery","volume":"9","author":"Han","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0054","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.adro.2018.11.008","article-title":"Machine learning methods uncover radiomorphologic dose patterns in salivary glands that predict xerostomia in patients with head and neck cancer","volume":"4","author":"Jiang","year":"2019","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0055","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1016\/j.clon.2016.02.009","article-title":"Recovery of salivary function: Contralateral parotid-sparing intensity-modulated radiotherapy versus bilateral superficial lobe parotid-sparing intensity-modulated radiotherapy","volume":"28","author":"Miah","year":"2016","journal-title":"Clin Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0056","doi-asserted-by":"crossref","DOI":"10.1088\/2057-1739\/aac8ea","article-title":"Heterogeneous radiotherapy dose-outcomes response in parotid glands","volume":"4","author":"Clark","year":"2018","journal-title":"Converg Sci Phys Oncol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0057","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jclinepi.2006.01.014","article-title":"Review: A gentle introduction to imputation of missing values","volume":"59","author":"Donders","year":"2006","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0058","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b2393","article-title":"Multiple imputation for missing data in epidemiological and clinical research: Potential and pitfalls","volume":"338","author":"Sterne","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.ijrobp.2023.04.034_bib0059","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jclinepi.2006.01.009","article-title":"Using the outcome for imputation of missing predictor values was preferred","volume":"59","author":"Moons","year":"2006","journal-title":"J Clin Epidemiol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301623004376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301623004376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T10:08:32Z","timestamp":1759745312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301623004376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0360301623004376"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2023.04.034","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of Radiation-Induced Parotid Gland-Related Xerostomia in Patients With Head and Neck Cancer: Regeneration-Weighted Dose","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2023.04.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}