{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:44:02Z","timestamp":1777869842748,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8262\/A7253"],"award-info":[{"award-number":["C8262\/A7253"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["SP2312\/021"],"award-info":[{"award-number":["SP2312\/021"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C1491\/A25351"],"award-info":[{"award-number":["C1491\/A25351"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C1491\/A9895"],"award-info":[{"award-number":["C1491\/A9895"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C1491\/A15955"],"award-info":[{"award-number":["C1491\/A15955"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C7224\/A28724"],"award-info":[{"award-number":["C7224\/A28724"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C33589\/A28284"],"award-info":[{"award-number":["C33589\/A28284"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000650","name":"Institute of Cancer Research","doi-asserted-by":"publisher","award":["C33589\/A19727"],"award-info":[{"award-number":["C33589\/A19727"]}],"id":[{"id":"10.13039\/501100000650","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ijrobp.2023.07.002","type":"journal-article","created":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T08:00:39Z","timestamp":1689494439000},"page":"1163-1173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gastrointestinal Toxicity Prediction Not Influenced by Rectal Contour or Dose-Volume Histogram Definition"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1130-4520","authenticated-orcid":false,"given":"Douglas H.","family":"Brand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah C.","family":"Br\u00fcningk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Wilkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Naismith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Syndikus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Dearnaley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"van As","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison C.","family":"Tree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Gulliford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2023.07.002_bib0001","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.juro.2018.01.002","article-title":"Clinically localized prostate cancer: AUA\/ASTRO\/SUO guideline. Part II: Recommended approaches and details of specific care options","volume":"199","author":"Sanda","year":"2018","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0002","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.eururo.2016.08.002","article-title":"EAU-ESTRO-SIOG guidelines on prostate cancer. Part II: Treatment of relapsing, metastatic, and castration-resistant prostate cancer","volume":"71","author":"Cornford","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0003","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0360-3016(03)00665-5","article-title":"Rectal dose-volume constraints in high-dose radiotherapy of localized prostate cancer","volume":"57","author":"Fiorino","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0004","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ijrobp.2009.02.025","article-title":"Dose-volume constraints to reduce rectal side effects from prostate radiotherapy: Evidence from MRC RT01 trial ISRCTN 47772397","volume":"76","author":"Gulliford","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0005","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.ijrobp.2020.01.003","article-title":"Derivation of Dose\/Volume Constraints for the Anorectum from Clinician- and Patient-Reported Outcomes in the CHHiP Trial of Radiation Therapy Fractionation","volume":"106","author":"Wilkins","year":"2020","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0006","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.radonc.2016.09.009","article-title":"Uncertainties in volume delineation in radiation oncology: A systematic review and recommendations for future studies","volume":"121","author":"Vinod","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0007","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0360-3016(03)00659-X","article-title":"The impact of contouring uncertainty on rectal 3D dose-volume data: Results of a dummy run in a multicenter trial (AIROPROS01-02)","volume":"57","author":"Foppiano","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0008","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0167-8140(01)00469-8","article-title":"Rectum contouring variability in patients treated for prostate cancer: Impact on rectum dose\u2013volume histograms and normal tissue complication probability","volume":"63","author":"Fiorino","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0009","doi-asserted-by":"crossref","first-page":"35001","DOI":"10.1088\/1361-6560\/aaa50c","article-title":"Correlations between contouring similarity metrics and simulated treatment outcome for prostate radiotherapy","volume":"63","author":"Roach","year":"2018","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0010","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s13014-014-0282-7","article-title":"Impact of treatment planning and delivery factors on gastrointestinal toxicity: An analysis of data from the RADAR prostate radiotherapy trial","volume":"9","author":"Yahya","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0011","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.radonc.2019.02.014","article-title":"Tolerance doses for late adverse events after hypofractionated radiotherapy for prostate cancer on trial NRG Oncology\/RTOG 0415","volume":"135","author":"Thor","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0012","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fonc.2020.00469","article-title":"Local dose effects for late gastrointestinal toxicity after hypofractionated and conventionally fractionated modern radiotherapy for prostate cancer in the HYPRO trial","volume":"10","author":"Heemsbergen","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0013","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.clon.2019.05.009","article-title":"Radiotherapy Quality Assurance for the CHHiP Trial: Conventional Versus Hypofractionated High-Dose Intensity-Modulated Radiotherapy in Prostate Cancer","volume":"31","author":"Naismith","year":"2019","journal-title":"Clin. Oncol."},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0014","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/00130404-200201000-00011","article-title":"Dose\/volume relationship of late rectal bleeding after external beam radiotherapy for localized prostate cancer: Absolute or relative rectal volume?","volume":"8","author":"Kupelian","year":"2002","journal-title":"Cancer J"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0015","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.ijrobp.2004.12.052","article-title":"Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy","volume":"62","author":"Vargas","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0016","first-page":"2741","article-title":"Association between rectal bleeding and the absolute dose volume of the rectum following image-guided radiotherapy for patients with prostate cancer","volume":"16","author":"Kotabe","year":"2018","journal-title":"Oncol Lett"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0017","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00066-018-1365-4","article-title":"Comparison of relative and absolute rectal dose\u2013volume parameters and clinical correlation with acute and late radiation proctitis in prostate cancer patients","volume":"195","author":"Paleny","year":"2019","journal-title":"Strahlentherapie und Onkol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0018","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20160370","article-title":"Comparison of different contouring definitions of the rectum as organ at risk (OAR) and dose-volume parameters predicting rectal inflammation in radiotherapy of prostate cancer: Which definition to use?","volume":"90","author":"Nitsche","year":"2017","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0019","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S1470-2045(16)30102-4","article-title":"Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial","volume":"17","author":"Dearnaley","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0020","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ijrobp.2020.12.041","article-title":"Estimates of Alpha\/Beta (\u03b1\/\u03b2) Ratios for Individual Late Rectal Toxicity Endpoints: An Analysis of the CHHiP Trial","volume":"110","author":"Brand","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0021","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1118\/1.1568978","article-title":"CERR: A computational environment for radiotherapy research","volume":"30","author":"Deasy","year":"2003","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0022","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2307\/1932409","article-title":"Measures of the amount of ecologic association between species","volume":"26","author":"Dice","year":"1945","journal-title":"Ecology"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0023","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1756-9966-28-117","article-title":"Modeling of alpha\/beta for late rectal toxicity from a randomized phase II study: Conventional versus hypofractionated scheme for localized prostate cancer","volume":"28","author":"Marzi","year":"2009","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0024","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ijrobp.2010.11.080","article-title":"Estimation of \u03b1\/\u03b2 for late rectal toxicity based on RTOG 94-06","volume":"81","author":"Tucker","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0025","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0026","first-page":"548","article-title":"Improvements on cross-validation: The .632+ bootstrap method","volume":"92","author":"Efron","year":"1997","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0027","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-8140(00)00191-2","article-title":"Target volume definition in conformal radiotherapy for prostate cancer: Quality assurance in the MRC RT-01 trial","volume":"56","author":"Seddon","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0028","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.ijrobp.2003.08.008","article-title":"Impact of volume and location of irradiated rectum wall on rectal blood loss after radiotherapy of prostate cancer","volume":"58","author":"Koper","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0029","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1748-717X-4-14","article-title":"Comparison of rectal volume definition techniques and their influence on rectal toxicity in patients with prostate cancer treated with 3D conformal radiotherapy: A dose-volume analysis","volume":"4","author":"Onal","year":"2009","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0030","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S0167-8140(18)30371-2","article-title":"OC-0061: Big-RT: Big data analysis to identify predictors of radiotherapy toxicity for personalised treatment","volume":"127","author":"Somaiah","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.07.002_bib0031","first-page":"62","article-title":"Radiotherapy dose-distribution to the perirectal fat space (PRS) is related to gastrointestinal control-related complications","volume":"7","author":"Gulliford","year":"2017","journal-title":"Clin Transl Radiat Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301623076289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301623076289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:49:55Z","timestamp":1777560595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301623076289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0360301623076289"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2023.07.002","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastrointestinal Toxicity Prediction Not Influenced by Rectal Contour or Dose-Volume Histogram Definition","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2023.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}