{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:48:36Z","timestamp":1792522116742,"version":"4.5.0"},"reference-count":111,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ijrobp.2023.10.044","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T05:03:02Z","timestamp":1698987782000},"page":"639-649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Predicting Radiation-Induced Lung Injury in Patients With Lung Cancer: Challenges and Opportunities"],"prefix":"10.1016","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9771-9825","authenticated-orcid":false,"given":"Merian E.","family":"Kuipers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista C.J.","family":"van Doorn-Wink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter S.","family":"Hiemstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies M.","family":"Slats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2023.10.044_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.acr.2022.03.007","article-title":"An overview of chemotoxicity and radiation toxicity in cancer therapy","volume":"155","author":"Yazbeck","year":"2022","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0002","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.chest.2019.03.033","article-title":"Radiation-induced lung injury: Assessment and management","volume":"156","author":"Hanania","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2015.09.001","article-title":"Radiation-induced lung damage - Clinical risk profiles and predictive imaging on their way to risk-adapted individualized treatment planning?","volume":"117","author":"Ebert","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0004","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3109\/0284186X.2012.718093","article-title":"A literature-based meta-analysis of clinical risk factors for development of radiation induced pneumonitis","volume":"51","author":"Vogelius","year":"2012","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijrobp.2005.03.047","article-title":"Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: Pulmonary function, prediction, and prevention","volume":"63","author":"Mehta","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0006","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1634\/theoncologist.2009-S104","article-title":"Radioprotectors and mitigators of radiation-induced normal tissue injury","volume":"15","author":"Citrin","year":"2010","journal-title":"Oncologist"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0007","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.ijrobp.2006.08.058","article-title":"Radiation pneumonitis and fibrosis: Mechanisms underlying its pathogenesis and implications for future research","volume":"66","author":"Tsoutsou","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0008","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fonc.2019.00877","article-title":"Radiation-induced lung injury (RILI)","volume":"9","author":"Giuranno","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0009","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s13014-021-01930-2","article-title":"Radiation pneumonitis in patients with non-small-cell lung cancer receiving chemoradiotherapy and an immune checkpoint inhibitor: A retrospective study","volume":"16","author":"Jang","year":"2021","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.radonc.2021.01.001","article-title":"Incidence, risk factors, and CT characteristics of radiation recall pneumonitis induced by immune checkpoint inhibitor in lung cancer","volume":"157","author":"Cousin","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0011","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/ijms20010024","article-title":"Combining radiotherapy and immunotherapy in lung cancer: Can we expect limitations due to altered normal tissue toxicity?","volume":"20","author":"Wirsd\u00f6rfer","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0012","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1056\/NEJMoa1709937","article-title":"Durvalumab after chemoradiotherapy in stage iii non-small-cell lung cancer","volume":"377","author":"Antonia","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0013","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Accessed July 10, 2023. https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/ctcae_v5_quick_reference_5x7.pdf"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0014","first-page":"552","article-title":"Radiation-induced lung injury - What do we know in the era of modern radiotherapy?","volume":"27","author":"Konkol","year":"2022","journal-title":"Rep Pract Oncol Radiother"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0015","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.radonc.2008.10.006","article-title":"Dyspnea evolution after high-dose radiotherapy in patients with non-small cell lung cancer","volume":"91","author":"De Ruysscher","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0016","series-title":"Radiobiology for the Radiologist","author":"Hall","year":"2019"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0017","series-title":"TCTP\/tpt1 - Remodeling Signaling from Stem Cell to Disease","first-page":"227","article-title":"The translationally controlled tumor protein and the cellular response to ionizing radiation-induced dna damage","author":"Zhang","year":"2017"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0018","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2011.12.012","article-title":"Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury","volume":"327","author":"Azzam","year":"2012","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/09553002.2014.934929","article-title":"Ionizing radiation-induced oxidative stress, epigenetic changes and genomic instability: The pivotal role of mitochondria","volume":"91","author":"Szumiel","year":"2015","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0020","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0165-2020","article-title":"Mitochondrial dysfunction in lung ageing and disease","volume":"29","author":"Cloonan","year":"2020","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0021","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41577-021-00568-1","article-title":"Immunomodulation by radiotherapy in tumour control and normal tissue toxicity","volume":"22","author":"Cytlak","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104745","article-title":"TGF-\u03b2 in radiotherapy: Mechanisms of tumor resistance and normal tissues injury","volume":"155","author":"Farhood","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0023","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: Many therapeutic avenues","volume":"34","author":"Birch","year":"2020","journal-title":"Genes Dev"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0024","article-title":"The importance of the vascular endothelial barrier in the immune-inflammatory response induced by radiotherapy","volume":"91","author":"Guipaud","year":"2018","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0025","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1158\/1078-0432.CCR-14-3193","article-title":"A hypoxia-induced vascular endothelial-to-mesenchymal transition in development of radiation-induced pulmonary fibrosis","volume":"21","author":"Choi","year":"2015","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0026","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jtho.2022.05.003","article-title":"Avoiding toxicity with lung radiation therapy: An IASLC perspective","volume":"17","author":"Bucknell","year":"2022","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0027","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2017.2032","article-title":"Proton beam radiotherapy and concurrent chemotherapy for unresectable stage III non-small cell lung cancer: Final results of a phase 2 study","volume":"3","author":"Chang","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0028","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008973","article-title":"Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice","volume":"6","author":"Favaudon","year":"2014","journal-title":"Sci Transl Med"},{"issue":"3 suppl","key":"10.1016\/j.ijrobp.2023.10.044_bib0029","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): An introduction to the scientific issues","volume":"76","author":"Bentzen","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-019-0064-5","article-title":"Radiotherapy toxicity","volume":"5","author":"De Ruysscher","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0031","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3390\/cancers10070222","article-title":"Radiation pneumonitis: Old problem, new tricks","volume":"10","author":"Jain","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0032","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140437","article-title":"Impact of preexisting interstitial lung disease on acute, extensive radiation pneumonitis: Retrospective analysis of patients with lung cancer","volume":"10","author":"Ozawa","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0033","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.ijrobp.2021.07.1691","article-title":"Predictors of pneumonitis after conventionally fractionated radiotherapy for locally advanced lung cancer","volume":"111","author":"McFarlane","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0034","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00050-2017","article-title":"Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients","volume":"50","author":"Delaunay","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0035","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.chest.2018.08.1048","article-title":"Immune checkpoint immunotherapy for non-small cell lung cancer: Benefits and pulmonary toxicities","volume":"154","author":"Suresh","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0036","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1200\/JCO.21.01308","article-title":"Five-year survival outcomes from the PACIFIC trial: Durvalumab after chemoradiotherapy in stage iii non-small-cell lung cancer","volume":"40","author":"Spigel","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0037","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ijrobp.2022.06.068","article-title":"Predictors of pneumonitis in combined thoracic stereotactic body radiation therapy and immunotherapy","volume":"114","author":"Korpics","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0038","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.ijrobp.2017.03.010","article-title":"Treatment-related toxicity in patients with early-stage non-small cell lung cancer and coexisting interstitial lung disease: A systematic review","volume":"98","author":"Chen","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0039","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1016\/j.clon.2022.01.043","article-title":"Is thoracic radiotherapy an absolute contraindication for treatment of lung cancer patients with interstitial lung disease? A systematic review","volume":"34","author":"Saha","year":"2022","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0040","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jtho.2020.02.005","article-title":"A primer on interstitial lung disease and thoracic radiation","volume":"15","author":"Goodman","year":"2020","journal-title":"J Thorac Oncol"},{"issue":"suppl 4","key":"10.1016\/j.ijrobp.2023.10.044_bib0041","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/annonc\/mdx222","article-title":"Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"28","author":"Postmus","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0042","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.ijrobp.2005.05.032","article-title":"Cytokine profiling for prediction of symptomatic radiation-induced lung injury","volume":"63","author":"Hart","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0043","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cyto.2009.11.017","article-title":"Cytokines in bronchoalveolar lavage fluid and serum of lung cancer patients during radiotherapy - Association of interleukin-8 and VEGF with survival","volume":"50","author":"Crohns","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0044","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0360-3016(00)01445-0","article-title":"Circulating IL-6 as a predictor of radiation pneumonitis","volume":"49","author":"Chen","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0045","doi-asserted-by":"crossref","first-page":"e2898","DOI":"10.1371\/journal.pone.0002898","article-title":"Cytokine plasma levels: Reliable predictors for radiation pneumonitis?","volume":"3","author":"Rube","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0046","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.canlet.2015.01.045","article-title":"Immunological markers that predict radiation toxicity","volume":"368","author":"Sprung","year":"2015","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0047","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109560","article-title":"A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer","volume":"9","author":"Siva","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0048","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ijrobp.2017.03.011","article-title":"Plasma levels of IL-8 and TGF-beta1 predict radiation-induced lung toxicity in non-small cell lung cancer: A validation study","volume":"98","author":"Wang","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2011.05.071","article-title":"Residual DNA and chromosomal damage in ex vivo irradiated blood lymphocytes correlated with late normal tissue response to breast radiotherapy","volume":"99","author":"Chua","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0050","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ijrobp.2009.08.052","article-title":"DNA repair alterations in children with pediatric malignancies: Novel opportunities to identify patients at risk for high-grade toxicities","volume":"78","author":"Rube","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0051","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/1354750X.2014.898099","article-title":"Gamma histone 2AX (gamma-H2AX) as a predictive tool in radiation oncology","volume":"19","author":"Pouliliou","year":"2014","journal-title":"Biomarkers"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0052","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ijrobp.2021.08.020","article-title":"Gamma-H2AX foci decay ratio as a stronger predictive factor of late radiation toxicity than dose-volume parameters in a prospective cohort of prostate cancer patients","volume":"112","author":"Nuijens","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0053","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.3390\/cancers12092517","article-title":"Monitoring DNA damage and repair in peripheral blood mononuclear cells of lung cancer radiotherapy patients","volume":"12","author":"Lobachevsky","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0054","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.7150\/jca.37708","article-title":"Precise prediction of the radiation pneumonitis in lung cancer: An explorative preliminary mathematical model using genotype information","volume":"11","author":"Du","year":"2020","journal-title":"J Cancer"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0055","doi-asserted-by":"crossref","first-page":"726","DOI":"10.7150\/jca.20643","article-title":"GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study","volume":"9","author":"Du","year":"2018","journal-title":"J Cancer"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0056","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cllc.2012.10.006","article-title":"Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin","volume":"14","author":"Kelsey","year":"2013","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0057","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13014-019-1456-0","article-title":"Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy","volume":"15","author":"Tang","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2022.101428","article-title":"Improved prediction of radiation pneumonitis by combining biological and radiobiological parameters using a data-driven Bayesian network analysis","volume":"21","author":"Hinton","year":"2022","journal-title":"Transl Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0059","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ijrobp.2009.08.058","article-title":"Quantifying local radiation-induced lung damage from computed tomography","volume":"76","author":"Ghobadi","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0060","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2015.07.017","article-title":"A new CT-based method to quantify radiation-induced lung damage in patients","volume":"117","author":"Ghobadi","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0061","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3109\/0284186X.2013.813074","article-title":"Quantification of radiation-induced lung damage with CT scans: The possible benefit for radiogenomics","volume":"52","author":"De Ruysscher","year":"2013","journal-title":"Acta Oncologica"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0062","first-page":"39","article-title":"Quantitative assessment and comparative analysis of longitudinal lung CT scans of chest-irradiated nonhuman primates","volume":"199","author":"Thakur","year":"2023","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0063","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3109\/0284186X.2012.731525","article-title":"Distinguishing radiation fibrosis from tumour recurrence after stereotactic ablative radiotherapy (SABR) for lung cancer: A quantitative analysis of CT density changes","volume":"52","author":"Mattonen","year":"2013","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0064","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijrobp.2010.05.017","article-title":"Computed tomography appearance of early radiation injury to the lung: correlation with clinical and dosimetric factors","volume":"81","author":"Jenkins","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0065","article-title":"Correlation between lung density changes under different dose gradients and radiation pneumonitis-based on an analysis of computed tomography scans during esophageal cancer radiotherapy","volume":"11","author":"Du","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0066","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1164\/rccm.202004-0951OC","article-title":"Computed tomography-based airway surface area-to-volume ratio for phenotyping airway remodeling in chronic obstructive pulmonary disease","volume":"203","author":"Bodduluri","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0067","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02618-2021","article-title":"Quantitative texture-based analysis of pulmonary parenchymal features on chest CT: Comparison with densitometric indices and short-term effect of changes in smoking habit","volume":"60","author":"Romei","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0068","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.3390\/cancers13081960","article-title":"Radiation-induced pneumonitis in the era of the COVID-19 pandemic: Artificial intelligence for differential diagnosis","volume":"13","author":"Giordano","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0069","article-title":"Deep learning-based triage and analysis of lesion burden for COVID-19: A retrospective study with external validation","volume":"2","author":"Wang","year":"2020","journal-title":"Lancet Digit Health"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0070","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/S2589-7500(22)00230-8","article-title":"Machine learning in radiology: The new frontier in interstitial lung diseases","volume":"5","author":"Barnes","year":"2023","journal-title":"Lancet Digit Health"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0071","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.radonc.2012.04.003","article-title":"[18F]-FDG uptake dose-response correlates with radiation pneumonitis in lung cancer patients","volume":"104","author":"McCurdy","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0072","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.ijrobp.2010.04.021","article-title":"Association between pulmonary uptake of fluorodeoxyglucose detected by positron emission tomography scanning after radiation therapy for non\u2013small-cell lung cancer and radiation pneumonitis","volume":"80","author":"Mac Manus","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0073","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1007\/s00259-019-04388-3","article-title":"PET-detected pneumonitis following curative-intent chemoradiation in non-small cell lung cancer (NSCLC): Recognizing patterns and assessing the impact on the predictive ability of FDG-PET\/CT response assessment","volume":"46","author":"Iravani","year":"2019","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0074","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.674731","article-title":"Lung function after stereotactic body radiation therapy for early-stage non-small cell lung cancer, changes and predictive markers","volume":"11","author":"Berg","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0075","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s13014-020-01694-1","article-title":"Severity of radiation pneumonitis, from clinical, dosimetric and biological features: A pilot study","volume":"15","author":"Aso","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0076","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.ijrobp.2018.04.014","article-title":"Longitudinal evaluation of lung function in patients with advanced non-small cell lung cancer treated with concurrent chemoradiation therapy","volume":"101","author":"Torre-Bouscoulet","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0077","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1164\/rccm.200909-1374ED","article-title":"Identifying chronic obstructive pulmonary disease and asthma by exhaled breath analysis: Does the (e)Nose know?","volume":"180","author":"Machado","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0078","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02042-2020","article-title":"Exhaled breath analysis by use of eNose technology: A novel diagnostic tool for interstitial lung disease","volume":"57","author":"Moor","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0079","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.chest.2022.09.042","article-title":"Diagnosing non-small cell lung cancer by exhaled-breath profiling using an electronic nose: A multicentre validation study","volume":"163","author":"Kort","year":"2023","journal-title":"Chest"},{"issue":"suppl 65","key":"10.1016\/j.ijrobp.2023.10.044_bib0080","first-page":"PA3869","article-title":"Identifying COVID-19-infected healthcare workers using an electronic \u2018nose\u2019","volume":"58","author":"Kurstjens","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0081","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/JTO.0000000000000182","article-title":"Feasibility and potential utility of multicomponent exhaled breath analysis for predicting development of radiation pneumonitis after stereotactic ablative radiotherapy","volume":"9","author":"Mor\u00e9","year":"2014","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0082","first-page":"1485","article-title":"Prospective exploratory study of the relationship between radiation pneumonitis and TGF-\u03b21 in exhaled breath condensate","volume":"36","author":"Takahashi","year":"2022","journal-title":"In vivo (Athens, Greece)"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0083","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3390\/cancers15020326","article-title":"Early identification of pneumonitis in patients irradiated for lung cancer-final results of the PARALUC trial","volume":"15","author":"Rades","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0084","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s11136-018-1834-3","article-title":"Patient-reported lung symptoms as an early signal of impending radiation pneumonitis in patients with non-small cell lung cancer treated with chemoradiation: An observational study","volume":"27","author":"Yue","year":"2018","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0085","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1080\/0284186X.2019.1634835","article-title":"Patient-reported lung symptoms and quality of life before and after radiation therapy for non-small cell lung cancer: correlation with radiation pneumonitis and functional imaging","volume":"58","author":"Farr","year":"2019","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0086","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00742-2019","article-title":"Airway and alveolar epithelial cells in culture","volume":"54","author":"Hiemstra","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0087","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pharmthera.2017.10.002","article-title":"Lung development, regeneration and plasticity: From disease physiopathology to drug design using induced pluripotent stem cells","volume":"183","author":"Ahmed","year":"2018","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0088","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1667\/RR1535.1","article-title":"Absence of inflammatory response from upper airway epithelial cells after X irradiation","volume":"171","author":"Reiter","year":"2009","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0089","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1667\/RR14045.1","article-title":"Role of pro-inflammatory cytokines in radiation-induced genomic instability in human bronchial epithelial cells","volume":"184","author":"Werner","year":"2015","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0090","doi-asserted-by":"crossref","first-page":"26406","DOI":"10.1074\/jbc.M114.573592","article-title":"miR-15b\/16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung","volume":"289","author":"Rahman","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0091","doi-asserted-by":"crossref","first-page":"L30","DOI":"10.1152\/ajplung.2001.280.1.L30","article-title":"Ionizing radiation enhances matrix metalloproteinase-2 production in human lung epithelial cells","volume":"280","author":"Araya","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0092","doi-asserted-by":"crossref","first-page":"L414","DOI":"10.1152\/ajplung.00197.2019","article-title":"NOTCH signaling promotes the survival of irradiated basal airway stem cells","volume":"317","author":"Giuranno","year":"2019","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0093","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/sctm.19-0278","article-title":"NOTCH inhibition promotes bronchial stem cell renewal and epithelial barrier integrity after irradiation","volume":"9","author":"Giuranno","year":"2020","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0094","doi-asserted-by":"crossref","first-page":"31669","DOI":"10.1038\/srep31669","article-title":"Organotypic culture in three dimensions prevents radiation-induced transformation in human lung epithelial cells","volume":"6","author":"El-Ashmawy","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0095","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3390\/cancers12030579","article-title":"Development and radiation response assessment in a novel syngeneic mouse model of tongue cancer: 2D culture, 3D organoids and orthotopic allografts","volume":"12","author":"Vincent-Chong","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0096","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0244513","article-title":"Three dimensional cultivation increases chemo- and radioresistance of colorectal cancer cell lines","volume":"16","author":"Koch","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0097","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1667\/RR3075","article-title":"Effects of single-dose irradiation on bronchial epithelium: A comparison of BEAS 2B cell monolayers, human organ cultures, and Goettinger minipigs","volume":"160","author":"Bergner","year":"2003","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0098","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115600","article-title":"CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation","volume":"9","author":"El-Ashmawy","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0099","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1667\/RR3371.1","article-title":"Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells","volume":"180","author":"Kim","year":"2013","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0100","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3892\/or.2013.2536","article-title":"Overexpression of TOB1 confers radioprotection to bronchial epithelial cells through the MAPK\/ERK pathway","volume":"30","author":"Che","year":"2013","journal-title":"Oncol Rep"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0101","doi-asserted-by":"crossref","first-page":"7064","DOI":"10.3390\/ijms22137064","article-title":"Metformin protects against radiation-induced acute effects by limiting senescence of bronchial-epithelial cells","volume":"22","author":"Hansel","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0102","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12032-020-01437-y","article-title":"The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues","volume":"37","author":"Manda","year":"2020","journal-title":"Med Oncol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0103","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115240","article-title":"ATP and ADP enhance DNA damage repair in \u03b3-irradiated BEAS-2B human bronchial epithelial cells through activation of P2X7 and P2Y12 receptors","volume":"407","author":"Kitabatake","year":"2020","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0104","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172548","article-title":"Ovatodiolide suppresses inflammatory response in BEAS-2B cells by regulating the CREB\/AQP5 pathway, and sensitizes nasopharyngeal carcinoma cells to radiation therapy","volume":"859","author":"Liu","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0105","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bbrc.2020.07.011","article-title":"Zbtb7b suppresses aseptic inflammation by regulating m(6)A modification of IL6 mRNA","volume":"530","author":"Zhao","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0106","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41419-020-03074-9","article-title":"Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem\/progenitor cell niche","volume":"11","author":"Peng","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0107","unstructured":"Submandibular gland stem cell transplantation (RESTART) 2023. ClinicalTrials.gov identifier: NCT04593589. Updated May 27, 2022. Accessed August 11 2023. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04593589?term=salivary+gland+AND+stem+cells&draw=2&rank=2"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0108","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41422-020-00453-x","article-title":"Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration","volume":"31","author":"Qu","year":"2021","journal-title":"Cell Res"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0109","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41576-022-00466-9","article-title":"Human organs-on-chips for disease modelling, drug development and personalized medicine","volume":"23","author":"Ingber","year":"2022","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0110","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/s41374-022-00830-7","article-title":"High-throughput proteomics: A methodological mini-review","volume":"102","author":"Cui","year":"2022","journal-title":"Lab Invest"},{"key":"10.1016\/j.ijrobp.2023.10.044_bib0111","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1158\/0008-5472.CAN-15-0262","article-title":"Evaluating robustness and sensitivity of the nanostring technologies nCounter platform to enable multiplexed gene expression analysis of clinical samples","volume":"75","author":"Veldman-Jones","year":"2015","journal-title":"Cancer Res"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301623080495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301623080495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T10:09:11Z","timestamp":1759745351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301623080495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":111,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0360301623080495"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2023.10.044","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predicting Radiation-Induced Lung Injury in Patients With Lung Cancer: Challenges and Opportunities","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2023.10.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}