{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:02:12Z","timestamp":1790136132367,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","redjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ijrobp.2024.08.034","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T06:33:07Z","timestamp":1726295587000},"page":"484-492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Using Integrin \u03b1v\u03b26-Targeted Positron Emission Tomography Imaging to Longitudinally Monitor Radiation-Induced Pulmonary Fibrosis In Vivo"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6562-088X","authenticated-orcid":false,"given":"William C.Y.","family":"Lo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian W. Villas","family":"Boas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truc T.","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Klaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Grogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Strong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Samson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford G.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buck E.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0886-5055","authenticated-orcid":false,"given":"Carmen","family":"Bergom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2024.08.034_bib0001","first-page":"1","article-title":"Scarred lung. An update on radiation-induced pulmonary fibrosis","volume":"7","author":"Jarzebska","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12061561","article-title":"Radiation-induced lung fibrosis: Preclinical animal models and therapeutic strategies","volume":"12","author":"Jin","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0003","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00432-015-1974-6","article-title":"Radiation-induced fibrosis: Mechanisms and implications for therapy","volume":"141","author":"Straub","year":"2015","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0004","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: From mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0005","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1164\/rccm.200706-806OC","article-title":"Inhibition of integrin \u03b1v\u03b26, an activator of latent transforming growth factor-\u03b2, prevents radiation-induced lung fibrosis","volume":"177","author":"Puthawala","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0006","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00259-019-04586-z","article-title":"Clinical quantification of the integrin \u03b1v\u03b26 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)","volume":"47","author":"Lukey","year":"2020","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0007","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.2967\/jnumed.113.120592","article-title":"Preclinical SPECT\/CT imaging of \u03b1v\u03b26 integrins for molecular stratification of idiopathic pulmonary fibrosis","volume":"54","author":"John","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0008","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/nm.3282","article-title":"Targeting of \u03b1v integrin identifies a core molecular pathway that regulates fibrosis in several organs","volume":"19","author":"Henderson","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0009","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.coph.2009.04.008","article-title":"Anti-inflammatory and pro-inflammatory roles of TGF-\u03b2, IL-10, and IL-22 in immunity and autoimmunity","volume":"9","author":"Sanjabi","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0010","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00441-016-2407-9","article-title":"\u0391v integrins: Key regulators of tissue fibrosis","volume":"365","author":"Conroy","year":"2016","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0011","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2353\/ajpath.2007.060158","article-title":"\u03b1v\u03b26 Integrin regulates renal fibrosis and inflammation in Alport mouse","volume":"170","author":"Hahm","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0012","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.1158\/0008-5472.CAN-07-1026","article-title":"Use of a peptide derived from foot-and-mouth disease virus for the noninvasive imaging of human cancer: Generation and evaluation of 4-[18F]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin \u03b1v\u03b26 expression with positron emission tomography","volume":"67","author":"Hausner","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0013","doi-asserted-by":"crossref","first-page":"784","DOI":"10.2967\/jnumed.114.150680","article-title":"The effect of bi-terminal PEGylation of an integrin \u03b1v\u03b26-targeted 18F peptide on pharmacokinetics and tumor uptake","volume":"56","author":"Hausner","year":"2015","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0014","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1158\/1078-0432.CCR-18-2665","article-title":"Preclinical development and first-in-human imaging of the integrin \u03b1v\u03b26 with [18F]\u03b1v\u03b26-binding peptide in metastatic carcinoma","volume":"25","author":"Hausner","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib34","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ijrobp.2020.02.014","article-title":"Integrin \u03b1v\u03b26 positron emission tomography imaging in lung cancer patients treated with pulmonary radiation therapy","volume":"107","author":"Saleem","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0015","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1038\/s41467-019-11863-w","article-title":"Evaluation of integrin \u03b1v\u03b26 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis","volume":"10","author":"Kimura","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0016","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1183\/09031936.00210414","article-title":"\u0391v\u03b26 integrin may be a potential prognostic biomarker in interstitial lung disease","volume":"46","author":"Saini","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0017","doi-asserted-by":"crossref","first-page":"eaaf4696","DOI":"10.1126\/scitranslmed.aaf4696","article-title":"Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models","volume":"9","author":"D\u00e9sog\u00e8re","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0018","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1021\/acs.molpharmaceut.1c00632","article-title":"Evaluation of copper-64-labeled \u03b1v\u03b26-targeting peptides: Addition of an albumin binding moiety to improve pharmacokinetics","volume":"18","author":"Ganguly","year":"2021","journal-title":"Mol Pharm"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0019","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijrobp.2009.12.074","article-title":"High dose-per-fraction irradiation of limited lung volumes using an image-guided, highly focused irradiator: Simulating stereotactic body radiotherapy regimens in a small-animal model","volume":"77","author":"Cho","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0020","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00408-015-9825-4","article-title":"Time, dose, and volume responses in a mouse pulmonary injury model following ablative irradiation","volume":"194","author":"Hong","year":"2016","journal-title":"Lung"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0021","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0969-8051(96)00157-6","article-title":"Efficient production of high specific activity 64Cu using a biomedical cyclotron","volume":"24","author":"McCarthy","year":"1997","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0022","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.apradiso.2012.03.009","article-title":"A semi-automated system for the routine production of copper-64","volume":"70","author":"Kume","year":"2012","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0023","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1152\/japplphysiol.00987.2016","article-title":"Assessment of cardiac fibrosis: A morphometric method comparison for collagen quantification","volume":"122","author":"Schipke","year":"2017","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0024","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)80545-0","article-title":"The integrin \u03b1v\u03b26 binds and activates latent TGF\u03b21: A mechanism for regulating pulmonary inflammation and fibrosis","volume":"96","author":"Munger","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0025","first-page":"A4023","article-title":"Quantification of integrin a v b 6 in fibrotic interstitial lung disease with a cystine knot PET tracer. A first in human study","volume":"199","author":"Mooney","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0026","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/MNM.0000000000001724","article-title":"Vimentin-targeted radiopeptide 99mTc-HYNIC-(tricine\/EDDA)-VNTANST: A promising drug for pulmonary fibrosis imaging","volume":"44","author":"Rezaeianpour","year":"2023","journal-title":"Nucl Med Commun"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0027","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.radonc.2016.05.007","article-title":"Pre-treatment non-target lung FDG-PET uptake predicts symptomatic radiation pneumonitis following stereotactic ablative radiotherapy (SABR)","volume":"119","author":"Chaudhuri","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0028","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2353\/ajpath.2007.060158","article-title":"\u0391v\u03b26 Integrin regulates renal fibrosis and inflammation in alport mouse","volume":"170","author":"Hahm","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0029","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/hep.21849","article-title":"Role of \u03b1v\u03b26 integrin in acute biliary fibrosis","volume":"46","author":"Wang","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0030","first-page":"1","article-title":"\u03b1v integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis","author":"Murray","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0031","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/hep4.1298","article-title":"An inhibitor of arginine-glycine-aspartate-binding integrins reverses fibrosis in a mouse model of nonalcoholic steatohepatitis","volume":"3","author":"Ulmasov","year":"2019","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0032","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jcmgh.2016.03.004","article-title":"Inhibitors of Arg-Gly-Asp-binding integrins reduce development of pancreatic fibrosis in mice","volume":"2","author":"Ulmasov","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.ijrobp.2024.08.034_bib0033","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1038\/s41467-020-18397-6","article-title":"Translational pharmacology of an inhaled small molecule \u03b1v\u03b26 integrin inhibitor for idiopathic pulmonary fibrosis","volume":"11","author":"John","year":"2020","journal-title":"Nat Commun"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301624032899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301624032899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T23:17:54Z","timestamp":1736983074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301624032899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0360301624032899"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2024.08.034","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Using Integrin \u03b1v\u03b26-Targeted Positron Emission Tomography Imaging to Longitudinally Monitor Radiation-Induced Pulmonary Fibrosis In Vivo","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2024.08.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}