{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:22:24Z","timestamp":1786990944732,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","redjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ijrobp.2024.09.030","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T02:04:28Z","timestamp":1726711468000},"page":"403-413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Proton-Based Radiation Therapy for Skull Base Chondrosarcomas in Children and Adolescents: 40-Year Experience From the Massachusetts General Hospital"],"prefix":"10.1016","volume":"121","author":[{"given":"Myrsini","family":"Ioakeim-Ioannidou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saveli","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Urell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Tejada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Petur","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin P.","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Patino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Rincon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tolia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ebb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Cote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Curry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drosoula","family":"Giantsoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-1337","authenticated-orcid":false,"given":"Shannon M.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2024.09.030_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2020.106153","article-title":"Incidence and survival rates and trends of skull Base chondrosarcoma: a population-based study","volume":"198","author":"Dibas","year":"2020","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0002","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.jocn.2009.05.003","article-title":"A systematic review of intracranial chondrosarcoma and survival","volume":"16","author":"Bloch","year":"2009","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0003","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1002\/cncr.23073","article-title":"Chordoma and chondrosarcoma: similar, but quite different, skull base tumors","volume":"110","author":"Almefty","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0004","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/00000478-199911000-00007","article-title":"Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma","volume":"23","author":"Rosenberg","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0005","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1148\/radiographics.12.4.1636034","article-title":"Chondrosarcoma: MR imaging with pathologic correlation","volume":"12","author":"Varma","year":"1992","journal-title":"RadioGraphics"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0006","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1634\/theoncologist.2011-0200","article-title":"Incidence, predictive factors, and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter study of 161 patients","volume":"16","author":"Verdegaal","year":"2011","journal-title":"Oncologist"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0007","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/PAP.0000000000000293","article-title":"The 2020 WHO classification of tumors of bone: an updated review","volume":"28","author":"Choi","year":"2021","journal-title":"Adv Anat Pathol"},{"issue":"Suppl 1","key":"10.1016\/j.ijrobp.2024.09.030_bib0008","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/1097-0142(19950101)75:1+<203::AID-CNCR2820751308>3.0.CO;2-V","article-title":"Bone cancers","volume":"75","author":"Dorfman","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0009","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00428-002-0641-x","article-title":"Towards a new understanding and classification of chondrogenic neoplasias of the skeleton\u2013biochemistry and cell biology of chondrosarcoma and its variants","volume":"441","author":"Aigner","year":"2002","journal-title":"Virchows Arch"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0010","doi-asserted-by":"crossref","first-page":"v204","DOI":"10.1093\/annonc\/mdq223","article-title":"Bone sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"21","author":"Hogendoorn","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0011","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.3390\/cancers15071962","article-title":"Chondrosarcoma resistance to radiation therapy: origins and potential therapeutic solutions","volume":"15","author":"Gilbert","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0012","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1055\/s-0029-1246218","article-title":"Cranial chondrosarcoma and recurrence","volume":"20","author":"Bloch","year":"2010","journal-title":"Skull Base"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0013","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijrobp.2006.08.027","article-title":"Carbon ion radiotherapy of skull base chondrosarcomas","volume":"67","author":"Schulz-Ertner","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0014","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/cncr.28606","article-title":"High control rate in patients with chondrosarcoma of the skull base after carbon ion therapy: first report of long-term results","volume":"120","author":"Uhl","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0015","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/neuonc\/nou347","article-title":"Image-guided, intensity-modulated radiation therapy (IG-IMRT) for skull base chordoma and chondrosarcoma: preliminary outcomes","volume":"17","author":"Sahgal","year":"2015","journal-title":"Neuro Oncol"},{"issue":"9","key":"10.1016\/j.ijrobp.2024.09.030_bib0016","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1093\/neuonc\/noad068","article-title":"Surgery and proton radiation therapy for pediatric base of skull chordomas: Long-term clinical outcomes for 204 patients","volume":"25","author":"Ioakeim-Ioannidou","year":"2023","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0017","unstructured":"U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. 2017."},{"issue":"Suppl 2","key":"10.1016\/j.ijrobp.2024.09.030_bib0018","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF03038890","article-title":"Proton therapy for tumors of the skull base","volume":"175","author":"Munzenrider","year":"1999","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0019","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/neuonc\/nov154","article-title":"Long-term outcomes and prognostic factors of skull-base chondrosarcoma patients treated with pencil-beam scanning proton therapy at the Paul Scherrer Institute","volume":"18","author":"Weber","year":"2016","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0020","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/cncr.31298","article-title":"High control rates of proton- and carbon-ion-beam treatment with intensity-modulated active raster scanning in 101 patients with skull base chondrosarcoma at the Heidelberg Ion Beam Therapy Center","volume":"124","author":"Mattke","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0021","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.3390\/cancers13174423","article-title":"Particle radiotherapy for skull base chondrosarcoma: a clinical series from Italian National Center for Oncological Hadrontherapy","volume":"13","author":"Riva","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0022","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ijrobp.2015.12.016","article-title":"Efficacy and safety of adjuvant proton therapy combined with surgery for chondrosarcoma of the skull base: a retrospective, population-based study","volume":"95","author":"Feuvret","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0023","doi-asserted-by":"crossref","first-page":"5960","DOI":"10.3390\/cancers13235960","article-title":"Primary skull base chondrosarcomas: a systematic review","volume":"13","author":"Palmisciano","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0024","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0360-3016(82)90512-0","article-title":"Fifteen year radiotherapy experience with chondrosarcoma of bone","volume":"8","author":"McNaney","year":"1982","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0025","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/cancers16050856","article-title":"Skull-base chondrosarcoma: a systematic review of the role of postoperative radiotherapy","volume":"16","author":"Ravindran","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0026","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3171\/jns.1999.91.3.0432","article-title":"Proton radiation therapy for chordomas and chondrosarcomas of the skull base","volume":"91","author":"Hug","year":"1999","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0027","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.clon.2010.09.011","article-title":"Residual postoperative tumour volume predicts outcome after high-dose radiotherapy for chordoma and chondrosarcoma of the skull base and spine","volume":"23","author":"Potluri","year":"2011","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0028","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1200\/JCO.19.02492","article-title":"Phase I study of the mutant IDH1 inhibitor ivosidenib: safety and clinical activity in patients with advanced chondrosarcoma","volume":"38","author":"Tap","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0029","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.3390\/cancers13102390","article-title":"Chondrosarcoma-from molecular pathology to novel therapies","volume":"13","author":"Zaj\u0105c","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2024.09.030_bib0030","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.3390\/cancers15184581","article-title":"Mesenchymal chondrosarcoma from diagnosis to clinical trials","volume":"15","author":"Dudzisz-\u015aled\u017a","year":"2023","journal-title":"Cancers (Basel)"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301624034011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301624034011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T18:18:42Z","timestamp":1736965122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301624034011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0360301624034011"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2024.09.030","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proton-Based Radiation Therapy for Skull Base Chondrosarcomas in Children and Adolescents: 40-Year Experience From the Massachusetts General Hospital","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2024.09.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}