{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T01:53:41Z","timestamp":1778205221901,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"am","delay-in-days":358,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006384","name":"American College of Radiology Imaging Network","doi-asserted-by":"publisher","award":["ZIA BC 011552"],"award-info":[{"award-number":["ZIA BC 011552"]}],"id":[{"id":"10.13039\/100006384","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"National Institutes of Health Clinical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ijrobp.2024.09.048","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T11:57:34Z","timestamp":1728475054000},"page":"986-994","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Phase 1 Trial of Image Guided Risk Volume-Adapted Postprostatectomy Radiation Therapy"],"prefix":"10.1016","volume":"122","author":[{"given":"Krishnan R.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Mena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay S.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kilian","family":"Salerno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Schott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie-Ann","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich P.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liza","family":"Lindenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Choyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baris","family":"Turkbey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4391-2734","authenticated-orcid":false,"given":"Deborah E.","family":"Citrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2024.09.048_bib0001","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.ijrobp.2020.11.064","article-title":"Factors influencing noncompletion of radiation therapy among men with localized prostate cancer","volume":"109","author":"Dee","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0002","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41585-019-0258-3","article-title":"Financial toxicity associated with treatment of localized prostate cancer","volume":"17","author":"Imber","year":"2020","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0003","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/jamaoncol.2023.7291","article-title":"Noninferiority of hypofractionated vs conventional postprostatectomy radiotherapy for genitourinary and gastrointestinal symptoms: The NRG-GU003 phase 3 randomized clinical trial","volume":"10","author":"Buyyounouski","year":"2024","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0004","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijrobp.2018.12.047","article-title":"Phase 1 trial of SBRT to the prostate fossa after prostatectomy","volume":"104","author":"Ballas","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0005","article-title":"Toxicity profile and patient-reported outcomes following salvage stereotactic ablative radiation therapy to the prostate bed: The POPART multicentric prospective study","volume":"44","author":"Ferrario","year":"2024","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0006","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.ijrobp.2020.11.009","article-title":"Hypofractionated postprostatectomy radiation therapy for prostate cancer to reduce toxicity and improve patient convenience: A phase 1\/2 trial","volume":"109","author":"Wages","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0007","article-title":"A phase 1 trial of highly conformal, hypofractionated postprostatectomy radiation therapy","volume":"7","author":"Patel","year":"2022","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0008","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2307\/2531693","article-title":"Design and analysis of phase I clinical trials","volume":"45","author":"Storer","year":"1989","journal-title":"Biometrics"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0009","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ijrobp.2009.02.006","article-title":"Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancer","volume":"76","author":"Michalski","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0010","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.0039","article-title":"Effect of standard vs dose-escalated radiation therapy for patients with intermediate-risk prostate cancer: The NRG Oncology RTOG 0126 randomized clinical trial","volume":"4","author":"Michalski","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0011","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1016\/S0140-6736(21)01790-6","article-title":"The addition of androgen deprivation therapy and pelvic lymph node treatment to prostate bed salvage radiotherapy (NRG Oncology\/RTOG 0534 SPPORT): An international, multicentre, randomised phase 3 trial","volume":"399","author":"Pollack","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0012","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1200\/JCO.20.03282","article-title":"Prostate-only versus whole-pelvic radiation therapy in high-risk and very high-risk prostate cancer (POP-RT): Outcomes from phase III randomized controlled trial","volume":"39","author":"Murthy","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0013","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.3390\/cancers14194956","article-title":"Dose-escalated salvage radiotherapy for macroscopic local recurrence of prostate cancer in the prostate-specific membrane antigen positron emission tomography era","volume":"14","author":"Tamihardja","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0014","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.euo.2023.02.013","article-title":"Prostatectomy bed image-guided dose-escalated salvage radiotherapy (SPIDER): An international multicenter retrospective study","volume":"6","author":"Benziane-Ouaritini","year":"2023","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0015","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/bju.14924","article-title":"Stereotactic radiotherapy for prostate bed recurrence after prostatectomy, a multicentric series","volume":"125","author":"Francolini","year":"2020","journal-title":"BJU Int"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0016","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.euo.2023.03.005","article-title":"Salvage stereotactic reirradiation for local recurrence in the prostatic bed after prostatectomy: A retrospective multicenter study","volume":"6","author":"Archer","year":"2023","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0017","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S1470-2045(16)30102-4","article-title":"Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial","volume":"17","author":"Dearnaley","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0018","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1200\/JCO.2016.71.7397","article-title":"Randomized trial of a hypofractionated radiation regimen for the treatment of localized prostate cancer","volume":"35","author":"Catton","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0019","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.eururo.2021.05.033","article-title":"Dose-intensified versus conventional-dose salvage radiotherapy for biochemically recurrent prostate cancer after prostatectomy: The SAKK 09\/10 randomized phase 3 trial","volume":"80","author":"Ghadjar","year":"2021","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0020","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijrobp.2019.09.047","article-title":"Toxicity and biochemical outcomes of dose-intensified postoperative radiation therapy for prostate cancer: Results of a randomized phase III trial","volume":"106","author":"Qi","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0021","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.euo.2022.01.001","article-title":"Prostate-specific membrane antigen positron emission tomography\/computed tomography is associated with improved oncological outcome in men treated with salvage radiation therapy for biochemically recurrent prostate cancer","volume":"5","author":"Meijer","year":"2022","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0022","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1007\/s00259-023-06185-5","article-title":"PSMA-PET\/CT-guided salvage radiotherapy in recurrent or persistent prostate cancer and PSA\u2009<\u20090.2 ng\/ml","volume":"50","author":"Solomonidou","year":"2023","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0023","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1200\/JCO.1999.17.4.1155","volume":"17","author":"Cox","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0024","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0140-6736(21)00581-X","article-title":"18F-fluciclovine-PET\/CT imaging versus conventional imaging alone to guide postprostatectomy salvage radiotherapy for prostate cancer (EMPIRE-1): A single centre, open-label, phase 2\/3 randomised controlled trial","volume":"397","author":"Jani","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2024.09.048_bib0025","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1158\/1078-0432.CCR-20-4573","article-title":"Diagnostic performance of 18F-DCFPyL-PET\/CT in men with biochemically recurrent prostate cancer: Results from the CONDOR phase III, multicenter study","volume":"27","author":"Morris","year":"2021","journal-title":"Clin Cancer Res"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301624034515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301624034515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:47:26Z","timestamp":1778158046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301624034515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0360301624034515"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2024.09.048","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Phase 1 Trial of Image Guided Risk Volume-Adapted Postprostatectomy Radiation Therapy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2024.09.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}