{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:28:08Z","timestamp":1778394488068,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","redjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ijrobp.2024.11.070","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T17:14:13Z","timestamp":1731690853000},"page":"1209-1218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Relationship Between Radiation-Induced Moyamoya Syndrome and Radiation Dose for Pediatric Patients Treated With Proton Radiation Therapy"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-323X","authenticated-orcid":false,"given":"Gobind S.","family":"Gill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujith","family":"Baliga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Lewy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin V.","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara L.","family":"Gallotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aibhlin","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Patteson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Speroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Omsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Rapalino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Musolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torunn I.","family":"Yock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2024.11.070_bib0001","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noy131","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011\u20132015","volume":"20","author":"Ostrom","year":"2018","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0002","first-page":"1","article-title":"Declines in cancer death rates among children and adolescents in the United States, 1999-2014","author":"Curtin","year":"2016","journal-title":"NCHS Data Brief"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0003","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3171\/2018.10.PEDS18377","article-title":"Childhood brain tumors: current management, biological insights, and future directions: JNSPG 75th Anniversary Invited Review Article","volume":"23","author":"Pollack","year":"2019","journal-title":"J Neurosurg Pediatr"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.pediatrneurol.2019.08.004","article-title":"Genetics of common pediatric brain tumors","volume":"104","author":"Malbari","year":"2020","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0005","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1056\/NEJMra2116344","article-title":"Brain tumors in children","volume":"386","author":"Cohen","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0006","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1056\/NEJMra0804622","article-title":"Moyamoya disease and moyamoya syndrome","volume":"360","author":"Scott","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0007","doi-asserted-by":"crossref","first-page":"S238","DOI":"10.1016\/S0303-8467(97)00082-6","article-title":"Guidelines for the diagnosis and treatment of spontaneous occlusion of the circle of Willis (\u201cmoyamoya\u201d disease). Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease) of the Ministry of Health and Welfare, Japan","volume":"99","author":"Fukui","year":"1997","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0008","doi-asserted-by":"crossref","first-page":"e694","DOI":"10.1542\/peds.2005-0568","article-title":"Moyamoya syndrome associated with down syndrome: outcome after surgical revascularization","volume":"116","author":"Jea","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0009","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3171\/ped.2004.100.2.0142","article-title":"Long-term outcome in children with moyamoya syndrome after cranial revascularization by pial synangiosis","volume":"100","author":"Scott","year":"2004","journal-title":"J Neurosur Pediatr"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3171\/PED\/2008\/1\/3\/211","article-title":"Surgical treatment of moyamoya syndrome in patients with sickle cell anemia: outcome following encephaloduroarteriosynangiosis","volume":"1","author":"Hankinson","year":"2008","journal-title":"PED"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0011","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1212\/01.wnl.0000257095.33125.48","article-title":"Moyamoya following cranial irradiation for primary brain tumors in children","volume":"68","author":"Ullrich","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0012","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1200\/JCO.19.01706","article-title":"Superior intellectual outcomes after proton radiotherapy compared with photon radiotherapy for pediatric medulloblastoma","volume":"38","author":"Kahalley","year":"2020","journal-title":"JCO"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0013","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.radonc.2014.08.017","article-title":"Quality of life outcomes in proton and photon treated pediatric brain tumor survivors","volume":"113","author":"Yock","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0014","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1002\/cam4.785","article-title":"Incidence and long-term outcome of postradiotherapy moyamoya syndrome in pediatric patients with primary brain tumors: a single institute experience in Taiwan","volume":"5","author":"Wu","year":"2016","journal-title":"Cancer Med"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0015","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.wneu.2018.12.048","article-title":"Radiation-induced moyamoya syndrome after proton therapy in child with clival chordoma: natural history and surgical treatment","volume":"123","author":"Scala","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0016","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1002\/pbc.24961","article-title":"The development of moyamoya syndrome after proton beam therapy: moyamoya syndrome after proton beam","volume":"61","author":"Zwagerman","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0017","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.ijrobp.2018.03.027","article-title":"Risk of radiation vasculopathy and stroke in pediatric patients treated with proton therapy for brain and skull base tumors","volume":"101","author":"Hall","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0018","first-page":"31","article-title":"Systematic review of the incidence and risk factors for cerebral vasculopathy and stroke after cranial proton and photon radiation for childhood brain tumors","volume":"8","author":"Bavle","year":"2021","journal-title":"Neurooncol Pract"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0019","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ijrobp.2017.07.009","article-title":"Radiation-induced large vessel cerebral vasculopathy in pediatric patients with brain tumors treated with proton radiation therapy","volume":"99","author":"Kralik","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0020","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1200\/JCO.2006.07.2884","article-title":"Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the childhood cancer survivor study","volume":"24","author":"Bowers","year":"2006","journal-title":"JCO"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0021","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ijrobp.2013.03.034","article-title":"Radiation, atherosclerotic risk factors, and stroke risk in survivors of pediatric cancer: a report from the childhood cancer survivor study","volume":"86","author":"Mueller","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0022","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ijrobp.2016.10.015","article-title":"Cerebrovascular diseases in childhood cancer survivors: role of the radiation dose to Willis circle arteries","volume":"97","author":"El-Fayech","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0023","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/ana.21981","article-title":"Pediatric moyamoya disease: an analysis of 410 consecutive cases","volume":"68","author":"Kim","year":"2010","journal-title":"Annal Neurol"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0024","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0360-3016(97)82497-2","article-title":"Large intracranial vessel occlusive vasculopathy after radiation therapy in children: Clinical features and usefulness of magnetic resonance imaging","volume":"38","author":"Omura","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s10143-023-02055-8","article-title":"The incidence of radiation-induced moyamoya among pediatric brain tumor patients who received photon radiation versus those who received proton beam therapy: a systematic review","volume":"46","author":"Elkatatny","year":"2023","journal-title":"Neurosurgical Rev"},{"key":"10.1016\/j.ijrobp.2024.11.070_bib0026","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.nec.2010.03.007","article-title":"Moyamoya: epidemiology, presentation, and diagnosis","volume":"21","author":"Smith","year":"2010","journal-title":"Neurosurg Clin N Am"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301624036393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301624036393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T19:19:24Z","timestamp":1745695164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301624036393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0360301624036393"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2024.11.070","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the Relationship Between Radiation-Induced Moyamoya Syndrome and Radiation Dose for Pediatric Patients Treated With Proton Radiation Therapy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2024.11.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}